A5019346291- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Advanced Polymer Synthesis and Characterization
- Surfactants and Colloidal Systems
- Advancements in Transdermal Drug Delivery
- Bee Products Chemical Analysis
- Curcumin's Biomedical Applications
- Drug Solubulity and Delivery Systems
- Mesoporous Materials and Catalysis
- Dendrimers and Hyperbranched Polymers
- Phytochemicals and Antioxidant Activities
- biodegradable polymer synthesis and properties
- Antioxidant Activity and Oxidative Stress
- Sirtuins and Resveratrol in Medicine
- Graphene and Nanomaterials Applications
- Essential Oils and Antimicrobial Activity
- Free Radicals and Antioxidants
- RNA Interference and Gene Delivery
- Nanoparticles: synthesis and applications
- Nanocomposite Films for Food Packaging
- Electrospun Nanofibers in Biomedical Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Drug Transport and Resistance Mechanisms
- Synthesis of Organic Compounds
- Proteins in Food Systems
Medical University of Sofia
2016-2025
Sofia University "St. Kliment Ohridski"
2008-2023
University of Chemical Technology and Metallurgy
2011-2012
Weatherford College
2011
Bulgarian Academy of Sciences
2008
University of Bayreuth
2008
Universidad de Navarra
2005-2008
Institute of Polymers
2008
Pharmaceutical Biotechnology (Czechia)
2004
In this study, doxorubicin was loaded in a chitosan-albumin nanogel with the aim of improving its stability and exploring potential system treatment skin cancer. Infrared spectroscopy X-ray diffraction confirmed encapsulation drug. Transmission electron microscopy revealed spherical shape particles. The drug-loaded characterized small diameter 29 nm, narrow polydispersity (0.223) positive zeta (+34 mV). exposure encapsulated to light (including UV irradiation daylight) did not provoke any...
Budesonide is a mineral corticoid applied in the local therapy of pediatric atopic dermatitis. Unfortunately, its dermal administration hindered by concomitant adverse effects and physicochemical properties. The characteristic pH change lesions can be utilized for preparation pH-sensitive nanocarrier. In this view, formulation Eudragit L 100 nanoparticles as budesonide delivery platform could provide more efficient release to desired site, improve penetration, subsequently lower undesired...
Oregano oil (OrO) possesses well-pronounced antimicrobial properties but its application is limited due to low water solubility and possible instability. The aim of this study was evaluate the possibility incorporate OrO in an aqueous dispersion chitosan-alginate nanoparticles how will affect activity. encapsulation performed by emulsification consequent electrostatic gelation both polysaccharides. OrO-loaded (OrO-NP) have small size (320 nm) negative charge (-25 mV). data from FTIR...
Resveratrol could be applied in wound healing therapies because of its antioxidant, anti-inflammatory and antibacterial effects. However, the main limitation resveratrol is low aqueous solubility. In this study, was included hydroxypropyl-β-cyclodextrin complexes further formulated Pluronic F-127 hydrogels for treatment therapy. IR-spectroscopy XRD analysis confirmed successful incorporation into complexes. The wound-healing ability these estimated by a scratch assay on fibroblasts, which...
Small-scale photobioreactors (PBRs) in the inoculum stage were designed with internal (red or green) and external white LED light as an initial step of a larger-scale installation aimed at fulfilling integral biorefinery concept for maximum utilization microalgal biomass multifunctional laboratory. The specific growth rate Scenedesmus obliquus (Turpin) Kützing given cultural conditions was analyzed by using MAPLE software. For determination total polyphenols, flavonoids, chlorophyll “a” “b”,...
The anthracycline antibiotic doxorubicin is a well-known antitumour agent, however its cardiotoxicity significant obstacle to therapy. aim of the present study was improve safety through simultaneous encapsulation with cardioprotective agent (resveratrol) in Pluronic micelles. formation and double-loading micelles performed via film hydration method. Infrared spectroscopy proved successful incorporation both drugs. X-ray diffraction analyses revealed that resveratrol loaded core, whereas...
Sulfadiazine-loaded silver nanoporous silica carriers have similar antibacterial properties as sulfadiazine.
Numerous studies reported that resveratrol (RVT) exhibits strong antioxidant and cytoprotective effects in brain pathologies, but its low solubility bioavailability limit therapeutic potential. Encapsulation of RVT nanoparticles offers a promising strategy to enhance effectiveness. The aim this study was evaluate the vitro cytoprotective, DNA protective, capacity resveratrol-loaded Pluronic (P123/F127) micelles. micellar (mRVT, water dispersion) pure (30% hydroethanolic solution) were...
Caffeine is a well-known xanthine that possesses antioxidant effects could contribute to its application in different skin disorders. In order enhance effects, approaches for improving permeation and penetration through layers be applied. This study emphasizes the preparation of caffeine–cyclodextrin complex formulation carbopol hydrogel. The was developed at 1:1 molar ratio between caffeine hydroxypropyl-β-cyclodextrin. It found enhanced radical scavenging activity against ABTS as well...
Oregano oil was successfully encapsulated into chitosan–albumin nanogel via emulsification and electrostatic gelation. The system characterized with a mean diameter around 26 nm, narrow size distribution (PDI = 0.242) approximately 40% encapsulation efficiency. incorporation of the confirmed by XRD FTIR analyses, dissolution enhanced after encapsulation. Furthermore, treatment Betacoronavirus 1 infected bovine kidney MDBK cells oregano oil-loaded (25 µg/mL) showed more than 50% protection...
Pilocarpine loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by solvent evaporation method and coated with various mucoadhesive polymers, in particular chitosan, sodium alginate poloxamers. The size of chitosan-coated was larger than the all other particles obtained. Their surface charge changed from negative (−22.8 mV) to positive (+61.0 mV). interaction between mucin took place up six hours according turbidimetric study. decreased significantly after incubation...