A5033464014- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Reproductive System and Pregnancy
- Chromosomal and Genetic Variations
- Immune responses and vaccinations
- Immune Response and Inflammation
- Nanomaterials for catalytic reactions
- Pregnancy and preeclampsia studies
- Chronic Myeloid Leukemia Treatments
- MicroRNA in disease regulation
- Meat and Animal Product Quality
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Muscle metabolism and nutrition
- Pharmacological Effects and Assays
Columbia University Irving Medical Center
2021-2024
Columbia University
2020-2024
New York Stem Cell Foundation
2020
Xavier University of Louisiana
2018
Westfield State University
1945
THE purpose of this investigation was to throw more light on the role carbonic anhydrase in mechanism eggshell formation, which still remains unexplained The calcium metabolism hen relation egg formation reviewed by Gutowska et al. (1943) a previous paper, where also discussed alkaline phosphatase formation. It concluded that deposition is independent local activity shell gland hen. If transformation colloid and phosphorus containing protein necessary for liberation calcium, place obscure....
While young blood can restore many aged tissues, its effects on the system itself and old hematopoietic stem cells (HSCs) have not been determined. Here, we used transplantation, parabiosis, plasma transfer, exercise, calorie restriction, aging mutant mice to understand of age-regulated systemic factors HSCs their bone marrow (BM) niche. We found that neither exposure blood, nor long-term residence in niches after parabiont separation, direct heterochronic transplantation had any observable...
Hematopoietic stem cells (HSC) and downstream lineage-biased multipotent progenitors (MPP) tailor blood production control myelopoiesis on demand. Recent lineage tracing analyses revealed MPPs to be major functional contributors steady-state hematopoiesis. However, we still lack a precise resolution of myeloid differentiation trajectories cellular heterogeneity in the MPP compartment. Here, found that myeloid-biased MPP3 are functionally molecularly heterogeneous, with distinct subset...
Summary The correction of disease-causing mutations in human embryos could reduce the burden inherited genetic disorders fetus and newborn, improve efficiency fertility treatments for couples with lieu embryo selection. Here we evaluate repair outcomes a Cas9-induced double-strand break (DSB) introduced on paternal chromosome at EYS locus, which carries frame-shift mutation causing blindness. We show that most common outcome is microhomology-mediated end joining, occurs during first cell...
Aging of the hematopoietic system promotes various blood, immune and systemic disorders is largely driven by stem cell (HSC) dysfunction (
Abstract The backbone of 2‐hydroxyisophthalic acid was identified as a potential metal oxide anchor because the perfect alignment all three its donor groups for binding to inorganic surfaces. It can therefore be used in design organic linkers based hybrid materials. Optimized and scalable methods synthesis ( 1 ) 5‐substituted derivatives: 5‐bromo‐ 2 ), 5‐sulfooxy‐ 3 5‐hydroxy‐ 4 5‐PEG600 5 are presented. Dynamic light scattering (DLS) demonstrated that compound inhibits Fe(OH) precipitation...
Hematopoietic aging is marked by a loss of regenerative capacity and skewed differentiation from hematopoietic stem cells (HSC) leading to dysfunctional blood production. Signals the bone marrow (BM) niche dynamically tailor hematopoiesis, but effect on microenvironment contribution still remains unclear. Here, we characterize inflammatory milieu in aged cavity that drives both stromal remodeling. We find decreased numbers functionality osteogenic mesenchymal (MSC) at endosteum expansion...
Abstract Hematopoietic aging is marked by a loss of regenerative capacity and skewed differentiation from hematopoietic stem cells (HSC) leading to impaired blood production. Signals the bone marrow (BM) niche tailor production, but contribution old remains unclear. Here, we characterize inflammatory milieu that drives both remodeling. We find decreased numbers functionality osteoprogenitors (OPr) expansion pro-inflammatory perisinusoidal mesenchymal stromal (MSC) with deterioration...
SUMMARY Neonates, in contrast to adults, are highly susceptible inflammation and infection. Here we investigate how late fetal liver (FL) mouse hematopoietic stem progenitor cells (HSPC) respond inflammation, testing the hypothesis that deficits engagement of emergency myelopoiesis (EM) pathways limit neutrophil output contribute perinatal neutropenia. We show despite similar molecular wiring as HSPCs have limited production myeloid at steady state fail activate a classical EM...