A5057094769- Bacteriophages and microbial interactions
- Bacillus and Francisella bacterial research
- Yersinia bacterium, plague, ectoparasites research
- Poxvirus research and outbreaks
- Monoclonal and Polyclonal Antibodies Research
- Transgenic Plants and Applications
- Muscle activation and electromyography studies
- Rabies epidemiology and control
- Transcranial Magnetic Stimulation Studies
- Viral Infections and Vectors
- Peripheral Nerve Disorders
- Reconstructive Surgery and Microvascular Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 epidemiological studies
- Virus-based gene therapy research
- Antimicrobial Resistance in Staphylococcus
- Brucella: diagnosis, epidemiology, treatment
- Pharmacological Effects of Natural Compounds
- Biochemical and Structural Characterization
- Viral Infections and Outbreaks Research
Combined Arms Academy of the Armed Forces of the Russian Federation
2010-2024
After the abolition of mandatory smallpox vaccination, humanity lost immunity not only to smallpox, but also infections caused by pathogens this family (Orthopoxvirus): monkeypox, cowpox, buffalo pox, camelpox. Since camelpox and African gerbil viruses are closest variola virus (genomic homology is 97%) in phylogenetic genetic terms, it cannot be ruled out that a mutation small fragment genome one these will lead replacement relatively safe with an epidemically dangerous pathogen. The...
The article presents the results of bioassays investigation by specialists Center for Special Laboratory Diagnostics Particularly Dangerous and Exotic Infectious Diseases, isolated during 2002–2015, obtained from deceased people suspected rabies virus infection. Outlined are main challenges working with received samples biological material dead ways handling these issues. Put forward pressing problems epizootic epidemiological bias that require comprehensive solutions on part healthcare...
Relevance. After smallpox eradication, in conditions of population immunity to orthopoxviruses absence, Monkeypox virus became most significant orthopoxvirus, pathogenic for humans. Therefore the generalization data on areas infection outbreaks, human diseases and methods prevention treatment monkey pox is important task. Aim. To characterize problem monkeypox world based an analysis foreign scientific publications over past 20 years. Materials methods. The work used presented main...
Objective of the study was development experimental ELISA tests and lateral flow immunoassays for detection staphylococcal enterotoxins, A B types. Materials methods . Hybridomas, producing monoclonal antibodies against enterotoxins from State Collection Affiliated Branch “48th Central Research Institute” Ministry Defense Russian Federation, BALB/c mice were used in research. Hybridoma cells incubated culture flasks peritoneal cavity mice. Monoclonal isolated ascitic fluids through...
Изучением морфологических особенностей, функциональной роли и механизмов образования гигантских клеток инородных тел занимались многие российские зарубежные ученые. Однако данных о возможной причастности этих клеток, вероятно опосредованно, к процессам регенерации тканей, окружающих эндопротезы, используемые в герниологии при пластике брюшной стенки не было выявлено. Такое состояние проблемы определило цель данного исследования: изучить морфологические особенности многоядерных имплантации...
Biological and physical-chemical properties of the pseudotuberculosis agent cultures were shown to be diverse in process submerged cultivation at various temperatures. The microbe increased temperature (37°C) was characterized by fast development death population. Decelerated lag phase extended exponential observed under conditions low temperature. culture grown 27 °C found get an intermediate position between those 10 37 °C.
The influence of artificial immunodeficiency state upon brucellosis course has been studied experimentally. Trials on laboratory animals demonstrated faster and more intensive progression infectious process as well increased frequency the fatal cases disease caused by agents.
Актуальность. Параневральные соединительнотканные структуры, образованные совокупностью фасциально-клетчаточных пространств и волокнистых образований расположенные между эпиневрием эпимизием прилежащих мышц, крайне тесно морфофункционально взаимосвязаны с нервным стволом. Однако, данных об адаптационных возможностях параневральных структур в условиях разной интенсивности двигательной активности конечности, литературе недостаточно. Целью данной работы явилось изучение реактивных изменений...
Objective . Optimization of vaccine virus cultivation in the suspended cell culture BHK-21 for infectious activity increment virus-containing suspension as base material smallpox preparations. Materials and methods We used line cells 72-hour age nutrient medium MEM type accordance with guidelines on preparation our studies. For challenging cells, (strain B-51) was used. The adapted through three consequent passages horion-allantois shell developing chicken embryos commercial dermovaccine...
The outbreaks of the Zaire ebolavirus (ZE) disease (ZED) that have arisen in last decade determine need to study infection pathogenesis, formation specific immunity forming as well development effective preventive and therapeutic means. All stages fight against ZED spread require experimental sensitive laboratory animals, which are rhesus monkeys case this .The aim is evaluate monkey cellular following ZE by means flow cytometry (cytofluorimetry).Male were intramuscularly infected dose 15...