A5066055109- Advanced Combustion Engine Technologies
- Combustion and flame dynamics
- Tryptophan and brain disorders
- Bacillus and Francisella bacterial research
- Metal complexes synthesis and properties
- Combustion and Detonation Processes
- Magnetism in coordination complexes
- Clostridium difficile and Clostridium perfringens research
- Insect Resistance and Genetics
- Advancements in Photolithography Techniques
- Stress Responses and Cortisol
- Advanced Surface Polishing Techniques
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Pickering emulsions and particle stabilization
- Insect and Pesticide Research
- Treatment of Major Depression
- Modular Robots and Swarm Intelligence
- Nanomaterials and Printing Technologies
- Health, psychology, and well-being
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Soft Robotics and Applications
- Family Support in Illness
- Semiconductor materials and devices
Institut National du Cancer
2019-2025
UCLouvain
2013-2023
Centre National de la Recherche Scientifique
1998-2023
Unité Matériaux et Transformations
2017-2023
Université de Lille
2020-2023
École Centrale de Lille
2020-2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2023
International Centre of Insect Physiology and Ecology
2022-2023
Université Jean Monnet
2020
Université Claude Bernard Lyon 1
2020
Abstract The major virulence factors of Clostridium difficile are toxins A and B. These encoded by tcdA tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation ( tcdR tcdC ) secretion tcdE ). To date, the PaLoc has always found same location is replaced non-toxigenic strains highly conserved 75/115 bp non-coding region. Here, we show new types C. loci through genome analysis atypical clinical describe for first time...
Abstract Clostridium difficile is a major cause of nosocomial infections. Bacterial persistence in the gut responsible for infection relapse; sporulation and other unidentified mechanisms contribute to this process. Intestinal bile salts cholate deoxycholate stimulate spore germination, while kills vegetative cells. Here, we report that sub-lethal concentrations biofilm formation, which protects C . from antimicrobial compounds. The matrix composed extracellular DNA proteinaceous factors...
Abstract Childhood cancers are a heterogeneous group of rare diseases, accounting for less than 2% all diagnosed worldwide. Most countries, therefore, do not have enough cases to provide robust information on epidemiology, treatment, and late effects, especially rarer types cancer. Thus, only through concerted effort share data internationally will we be able answer research questions that could otherwise answered. With this goal in mind, the U.S. National Cancer Institute French...
Optimized ab initio molecular orbital calculations on nine bridgehead bicyclic lactams ranging from the 2.2.2 to 4.3.3 series indicate variations in structural properties, resonance energies, proton affinities, and core ionization energies that reflect trans-cycloalkene analogy. The smaller are calculated be N-protonated, larger O-protonated, "crossover" is predicted occur around 3.3.1 system. On basis of could considered hyperstable as Schleyer co-workers define concept for alkenes. This,...
Summary In sporulating Bacillus , major processes like virulence gene expression and sporulation are regulated by communication systems involving signalling peptides regulators of the RNPP family. We investigated role one such regulator, NprR, in bacteria cereus group. show that NprR is a transcriptional regulator whose activity depends on NprX peptide. association with NprX, activates transcription an extracellular protease ( nprA ) during first stage process. The start site has been...
How pathogenic bacteria infect and kill their host is currently widely investigated. In comparison, the fate of pathogens after death receives less attention. We studied Bacillus thuringiensis (Bt) infection an insect host, show that NprR, a quorum sensor, active allows Bt to survive in cadavers as vegetative cells. Transcriptomic analysis revealed NprR regulates at least 41 genes, including many encoding degradative enzymes or proteins involved synthesis nonribosomal peptide named...
The entomopathogen Bacillus thuringiensis produces dense biofilms under various conditions. Here, we report that the transition phase regulators Spo0A, AbrB and SinR control biofilm formation swimming motility in B. thuringiensis, just as they swarming closely related saprophyte species subtilis. However, microarray analysis indicated contrast to subtilis, does not an eps operon involved exopolysaccharides production, but regulates genes biosynthesis of lipopeptide kurstakin. This is...
The pathogenicity of Clostridium difficile is linked to its ability produce two toxins: TcdA and TcdB. level toxin synthesis influenced by environmental signals, such as phosphotransferase system (PTS) sugars, biotin, amino acids, especially cysteine. To understand the molecular mechanisms cysteine-dependent repression production, we reconstructed sulfur metabolism pathways C. strain 630 in silico validated some them testing growth presence various sources. High levels sulfide pyruvate were...
The emergent human enteropathogen Clostridioides difficile is the main cause of diarrhea associated with antibiotherapy. Regulatory pathways underlying adaptive responses remain understudied and global view C. promoter structure still missing. In genome 630, 22 genes encoding sigma factors are present suggesting a complex pattern transcription in this bacterium. We here first transcriptional map resulting from identification start sites (TSS), motifs operon structures. By differential...
Spore-forming bacteria of the Bacillus subtilis group are responsible for recurrent contamination processing lines in food industry which can lead to spoilage. The persistence B. would be due high resistance spores extreme environmental condition and their propensity contaminate surfaces. While it is well known that sporulation conditions modulate spore properties, little about effect on surface adhesion properties. Here, we studied impact 13 properties 168 spores. We showed Ca2+ or Mg2+...
For the human pathogen Clostridioides (also known as Clostridium) difficile, ability to adapt nutrient availability is critical for its proliferation and production of toxins during infection. Synthesis regulated by certain carbon sources, fermentation products amino acids (e.g. proline, cysteine, isoleucine, leucine valine). The effect proline attributable at least in part role an inducer substrate D-proline reductase (PR), a Stickland reaction that regenerates NAD+ from NADH. Many...
The oxidation of n-propylcyclohexane (C9H18) was experimentally studied using the shock tube and spherical bomb techniques. Both devices were heated in order to prevent wall adsorption. Ignition delay times, τi, n-propylcyclohexane/O2/Ar mixtures based on OH* CH* radicals chemiluminescence have been measured behind reflected waves over a large range temperatures (1250−1800 K), pressures (10−20 bar), equivalence ratios (0.2−1.5). Laminar flame speeds at an initial temperature 403 K pressure 1...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFive-coordination. IV. Nickel(II) complexes of diphenyl(o-diphenylarsinophenyl)phosphineThomas D. Dubois and Devon W. MeekCite this: Inorg. Chem. 1967, 6, 7, 1395–1398Publication Date (Print):July 1, 1967Publication History Published online1 May 2002Published inissue 1 July 1967https://pubs.acs.org/doi/10.1021/ic50053a024https://doi.org/10.1021/ic50053a024research-articleACS PublicationsRequest reuse permissionsArticle...
NprR is a quorum sensor of the RNPP family found in bacteria Bacillus cereus group. In association with its cognate peptide NprX, controls expression genes essential for survival and sporulation thuringiensis during necrotrophic development insects. Here, we report that nprR-nprX are not autoregulated co-transcribed from σ(A) -dependent promoter (PA ) located upstream nprR. The transcription PA starts at onset stationary phase controlled by two transcriptional regulators: CodY PlcR....
Bacillus species are a major economic and food safety concern of the industry because their spoilage-causing capability persistence. Their persistence is mainly due to ability form highly resistant spores adhering surfaces industrial equipment. Spores subtilis group surrounded by crust, superficial layer which plays key role in adhesion properties. However, knowledge composition structure this remains incomplete. Here, for first time, we identified nonulosonic acid (Leg) at bacterial ( B. )....
Integrated force arrays (IFAs), which are flexible metallized membranes that can be patterned using the techniques of VLSI electronics and undergo substantial deformation when voltage is applied, have been developed. They may configured as macroscopic actuators or used in highly articulated systems great complexity. The theory operation, methods construction, observational results for IFA test structures presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML"...