A5010653184- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- Computational Drug Discovery Methods
- Climate Change and Health Impacts
- Reproductive tract infections research
- Insect and Pesticide Research
- SARS-CoV-2 detection and testing
- Research on Leishmaniasis Studies
- Phytochemicals and Medicinal Plants
- COVID-19 impact on air quality
- Traditional and Medicinal Uses of Annonaceae
- Curcumin's Biomedical Applications
- Alkaloids: synthesis and pharmacology
- Cinema History and Criticism
- Media and Digital Communication
- Air Quality and Health Impacts
- Vaccine Coverage and Hesitancy
- Phytochemistry and Bioactivity Studies
- Finance, Taxation, and Governance
- Animal health and immunology
- Herbal Medicine Research Studies
- Knowledge Societies in the 21st Century
- Medicinal Plants and Neuroprotection
- South Asian Cinema and Culture
Universidad de Antioquia
2016-2025
Universidad Cooperativa de Colombia
2021-2022
Pontificia Universidad Javeriana
2004
Hospital Universitario de Maracaibo
2004
St. Joseph Medical Center
2002
Convalescent plasma (CP) has emerged as a treatment for COVID-19. However, the composition and mechanism of action are not fully known. Therefore, we undertook two-phase controlled study in which, first immunological metabolomic status recovered severe patients were evaluated. Secondly, 28-day effect CP on immune response was assessed. Nineteen COVID-19 patients, 18 hospitalized with disease, 16 pre-pandemic controls included. Patients disease treated transfusion standard therapy (i.e.,...
Due to the scarcity of therapeutic approaches for COVID-19, we investigated antiviral and anti-inflammatory properties curcumin against SARS-CoV-2 using in vitro models. The cytotoxicity was evaluated MTT assay Vero E6 cells. activity this compound four treatment strategies (i. pre–post infection treatment, ii. co-treatment, iii. pre-infection, iv. post-infection). D614G strain Delta variant were used, viral titer quantified by plaque assay. effect peripheral blood mononuclear cells (PBMCs)...
SARS-CoV-2 vaccines have shown very high effectiveness in real-world scenarios. However, there is compelling evidence for a fast-paced waning of immunity. The increasing number new variants that could alter the severity, transmissibility, and potential to evade immune response raised significant concern. Therefore, elucidating changes humoral against viral induced by over time crucial improving immunization protocols. We carried out 6-month longitudinal prospective study which 60 individuals...
In the last decades, a decrease in air quality has been observed, mainly associated with anthropogenic activities. Air pollutants, including particulate matter (PM), have adverse effects on human health, such as exacerbation of respiratory diseases and infections. High levels PM recently increased morbidity mortality COVID-19 some regions world.To evaluate effect coarse (PM10) inflammatory response viral replication triggered by SARS-CoV-2 using vitro models.Peripheral blood mononuclear...
El objetivo central fue registrar la estrategia de apropiación TIC, acorde a las necesidades comunidades los municipios zona influencia del Páramo Santurbán para conseguir vincularlos con actividades bienestar social promovidas por Fundación Alianza BioCuenca través proyecto miPáramo. Las TIC pueden ser un elemento que potencia el desarrollo, pero hacer efectivo este potencial depende aspectos organizativos, desarrollo habilidades y capacidades, acciones integración dentro identidad cultural...
Introduction: Currently, there are no effective medications for treating all the clinical conditions of patients with COVID-19. We aimed to evaluate antiviral activity compounds derived from L-tyrosine against B.1 lineage SARS-CoV-2 in vitro and silico. Methodology: The cytotoxicities 15 halogenated were evaluated Vero-E6 cells by MTT assay. was using four strategies, viral quantification performed a plaque assay qRT-PCR. toxicity ADMET predictor software. affinity these or cellular proteins...
AISI 420 martensitic stainless steel is used for the manufacture of surgical and dental instruments, among others, whose surfaces can be colonized by bacteria and/or viruses that negatively affect health patients. The use binary ternary nitride coatings doped with different metallic nanoparticles has contributed to reducing problems infection bacteria. However, there are few reports studies on biocidal virucidal effect high-entropy silver nanoparticles, which could an important alternative...
This article evaluated the in vitro antiviral effect of atorvastatin (ATV) against SARS-CoV-2 and identified interaction affinity between this compound two proteins. The activity virus was by three different treatment strategies [(i) pre-post treatment, (ii) pre-infection (iii) post-infection treatment] using Vero E6 Caco-2 cells. with RdRp (RNA-dependent RNA polymerase) 3CL protease (3-chymotrypsin-like protease) molecular docking. CC50s (half-maximal cytotoxic concentrations) obtained for...
<abstract><sec> <title>Background</title> <p>Drug repurposing is a valuable strategy for rapidly developing drugs treating COVID-19. This study aimed to evaluate the antiviral effect of six antiretrovirals against SARS-CoV-2 in vitro and silico.</p> </sec><sec> <title>Methods</title> <p>The cytotoxicity lamivudine, emtricitabine, tenofovir, abacavir, efavirenz raltegravir on Vero E6 was evaluated by MTT assay. The activity...
The coronavirus disease 2019 (COVID-19) has become a serious problem for public health since it was identified in the province of Wuhan (China) and spread around world producing high mortality rates economic losses. Nowadays, WHO recognizes traditional, complementary, alternative medicine treating COVID-19 symptoms. Therefore, we investigated antiviral potential hydroalcoholic extract Uncaria tomentosa stem bark from Peru against SARS-CoV-2 vitro. activity U. vitro assessed Vero E6 cells...
Currently, no specific licensed antiviral exists for treating the illness caused by dengue virus (DENV). Therefore, search compounds of natural origin with activity is an important area research. In present study, three were isolated and identified from seeds Tabernaemontana cymosa plants. The in vitro effect those voacangine against different DENV strains was assessed using experimental approaches: added before infection (Pre), at same time (Trans), after (Post) or all moments experiment...
Background and Objectives: SARS-CoV-2 variants of concern (VOC) interest (VOI) pose a significant threat to pub- lic health because the rapid change in genome can alter viral phenotypes such as virulence, transmissi- bility ability evade host response. Hence, quantification techniques are essential for timely diagnosis follow-up. Besides, they vital understanding pathogenesis, antiviral evaluation, vaccine de- velopment. Materials Methods: Five isolates SARS-CoV-2: D614G strain (B.1), three...
It has been proposed that polyphenols can be used in the development of new therapies against COVID-19, given their ability to interfere with adsorption and entrance processes virus, thus disrupting viral replication. Seeds from Caesalpinia spinosa, have traditionally for treatment inflammatory pathologies respiratory diseases. Our team obtained an extract called P2Et, rich derived gallic acid significant antioxidant activity, induce complete autophagy tumor cells reduce systemic response...
Background: Coronavirus infectious disease 2019 (COVID-19) caused by the infection with new coronavirus SARS-CoV-2 has affected life and health of more than 222 million people. In absence any specific pharmacological treatment, need to find therapeutic alternatives is clear. Medicinal plants are widely used worldwide treat different conditions, including COVID-19; however, in most cases, there no studies evaluate efficacy these treatments. Objective: This article evaluates antiviral effect...
Abstract Introduction SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has caused a pandemic of historic proportions and continues to spread worldwide. Currently, there is no effective therapy against this virus. This article evaluated the in vitro antiviral effect Atorvastatin also identified interaction affinity between three proteins, using silico structure-based molecular docking approach. Materials methods The activity was by different treatment strategies clinical isolate...
Background Despite its proven effectiveness and safety, there are limited real-world data on CoronaVac’s immunogenicity in children, especially lower-income countries, particularly for SARS-CoV-2 variants. We present a study evaluating Colombian children stratified by previous exposure to this virus. Methods 89 aged 3-11 years were enrolled (50 Non-Exposed 39 Exposed). Saliva samples collected every 15 days monitor potential infection, blood taken at two six months after vaccination,...
Introduction: Immunological markers have been described during COVID-19 and persist after recovery. These immune are associated with clinical features among SARSCoV-2 infected individuals. Nevertheless, studies reporting a comprehensive analysis of the changes occurring SARS-CoV-2 infection still limited.Objective: To evaluate production proinflammatory cytokines, antibody response, phenotype function NK cells T in Colombian family cluster infection.Materials methods: Proinflammatory...
Background: Given the current COVID-19 pandemic, numerous drug development studies are being carried out for treatment and control of this disease. This study aimed to evaluate in vitro antiviral potential Corozo fruit extract (Bactris guineensis) against SARS-CoV-2.Methods: (CE) was prepared from pulp mature fruits. The total content phenols, flavonoids, anthocyanins extracts determined using Folin-Ciocalteu, aluminum chloride, pH differential methods, respectively. cytotoxicity on Vero E6...
The emergence of the Omicron variant has generated concerns about efficacy COVID-19 vaccines. We evaluated serum neutralizing activity antibodies against (lineage BA.1.1) by plaque reduction test, as well its correlation with age and gender, in a Colombian cohort six months after being vaccinated BNT162b2 (Pfizer/BioNTech). Compared to all other variants analyzed, significantly lower (p<0.001) was observed Omicron. Interestingly, older individuals exhibited titers than those younger 40. No...
Abstract The coronavirus disease 2019 (COVID-19) has become a serious problem for public health since it was identified in the province of Wuhan (China) and spread around world producing high mortality rates economic losses. Nowadays, WHO recognizes traditional, complementary, alternative medicine treating COVID-19 symptoms. Therefore, we investigated antiviral potential hydroalcoholic extract Uncaria tomentosa stem bark from Peru against SARS-CoV-2 vitro . activity U. assessed Vero E6 cells...
Este articulo tiene como objetivo presentar un balance historiografico sobre la television colombiana, en el cual incluimos analisis de textos tanto caracter cientifico elaborado por expertos materia, documentos productos recuperacion memoria individual, autobiografias y ensayos tema; autores provenientes diversas disciplinas filosofos, psicologos, comunicadores, historiadores, actores, etc. Nuestro interes no es caer celebracionismo basado idea ?todo pasado fue mejor? o justificacion...