A5055570429- Mosquito-borne diseases and control
- HIV Research and Treatment
- Malaria Research and Control
- Influenza Virus Research Studies
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactivity Studies
- Pharmacological Effects of Natural Compounds
- HIV/AIDS drug development and treatment
- Viral Infections and Vectors
- Piperaceae Chemical and Biological Studies
- Plant biochemistry and biosynthesis
Universidad Cooperativa de Colombia
2020-2024
Currently, no specific licensed antiviral exists for treating the illness caused by dengue virus (DENV). Therefore, search compounds of natural origin with activity is an important area research. In present study, three were isolated and identified from seeds Tabernaemontana cymosa plants. The in vitro effect those voacangine against different DENV strains was assessed using experimental approaches: added before infection (Pre), at same time (Trans), after (Post) or all moments experiment...
In recent years, an increase in the occurrence of illnesses caused by two clinically- important arboviruses has been reported: Zika virus (ZIKV) and Chikungunya (CHIKV). There is no licensed antiviral treatment for either abovementioned viruses. Bearing mind that effect indole alkaloids reported other arboviral models, present study proposed to evaluate vitro silico effects four on infections these viruses different cell lines.The voacangine (VOAC), voacangine-7-hydroxyindolenine (VOAC-OH),...
Despite the serious public health problem represented by diseases caused dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses, there are still no specific licensed antivirals available for their treatment. Here, we examined potential anti-arbovirus activity of ten di-halogenated compounds derived from L-tyrosine with modifications in amine carboxyl groups. The on VERO cell line infection possible mechanism action most promising were evaluated. Finally, molecular docking between viral...
Although the disease caused by chikungunya virus (CHIKV) is of great interest to public health organizations around world, there are still no authorized antivirals for its treatment. Previously, dihalogenated anti-CHIKV compounds derived from L-tyrosine (dH-Y) were identified as being effective against in vitro infection this virus, so objective study was determine mechanisms antiviral action. Six dH-Y (C1 C6) with bromine or chlorine and modified their amino groups evaluated different...