A5012807433- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Phenothiazines and Benzothiazines Synthesis and Activities
- HIV Research and Treatment
- Click Chemistry and Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Trypanosoma species research and implications
- Cytomegalovirus and herpesvirus research
- Respiratory viral infections research
- Cocoa and Sweet Potato Agronomy
- Malaria Research and Control
- Drug Transport and Resistance Mechanisms
- thermodynamics and calorimetric analyses
- Viral Infections and Vectors
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Helicobacter pylori-related gastroenterology studies
- Peptidase Inhibition and Analysis
Universidad de Antioquia
2016-2025
Introduction: Currently, there are no effective medications for treating all the clinical conditions of patients with COVID-19. We aimed to evaluate antiviral activity compounds derived from L-tyrosine against B.1 lineage SARS-CoV-2 in vitro and silico. Methodology: The cytotoxicities 15 halogenated were evaluated Vero-E6 cells by MTT assay. was using four strategies, viral quantification performed a plaque assay qRT-PCR. toxicity ADMET predictor software. affinity these or cellular proteins...
Despite the serious public health problem represented by diseases caused dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses, there are still no specific licensed antivirals available for their treatment. Here, we examined potential anti-arbovirus activity of ten di-halogenated compounds derived from L-tyrosine with modifications in amine carboxyl groups. The on VERO cell line infection possible mechanism action most promising were evaluated. Finally, molecular docking between viral...
A new alkaloid, Canthin-6-one, Huberine (1), together with three known compounds including 1-Hydroxy-canthin-6-one (2), Canthin-6-one (3) and stigma sterol (4), were isolated from the stem bark of Picrolemma huberi. The isolation was achieved by chromatographic techniques purification performed on a C18 column using acetonitrile/water (90:10, v/v) 0.1% formic acid as mobile phase. structural elucidation via spectroscopic methods, notably 1D- 2D-NMR, UV, IR, MS HRMS. antiplasmodial activity studied.
We synthesized twelve hybrids, S-allyl Cysteine methyl, ethyl and propyl ester-based non-steroidal anti-inflammatory drugs their structures were elucidated by spectroscopic analysis. The chemopreventive potential of all compounds was evaluated against SW480 human colon adenocarcinoma cells the non-malignant CHO-K1 cell line. Among tested compounds, hybrids 10b-c, 11b 12b displayed best anticancer activity with IC50 values between 0.131-0.183 mM selectivity indices higher than 1 after 48 h...
Although the disease caused by chikungunya virus (CHIKV) is of great interest to public health organizations around world, there are still no authorized antivirals for its treatment. Previously, dihalogenated anti-CHIKV compounds derived from L-tyrosine (dH-Y) were identified as being effective against in vitro infection this virus, so objective study was determine mechanisms antiviral action. Six dH-Y (C1 C6) with bromine or chlorine and modified their amino groups evaluated different...
Objectives. To make the synthesis of halogenated derivatives on nitrogenous base and their respective acyl ester amide type for all hydroxyl amine groups uridine cytarabine nucleosides, evaluate cytotoxicity against breast cancer cell line. Methods. First, it was accomplished halogenation reaction 5-position base, subsequently, were performed group present in nucleosides. Besides, acetonide as prepared by acid catalysis. The products characterized nuclear magnetic resonance spectroscopy (1H...
A series of twenty-one L-tyrosine derivatives with modifications in the halogenation pattern aromatic ring and different degree methylations on amine phenolic hydroxyl groups were synthesized.The structures all intermediates target compounds confirmed unambiguous by spectroscopy analysis.Additionally, evaluated against Plasmodium falciparum Leishmania panamensis parasites between 20-702 µg mL -1 .The cytotoxic evaluation was done to determine selectivity index for each compound.Six had lower...
Novel iodotyramides with para-substituted benzoic acids were synthesized via electrophilic aromatic substitutions and amide coupling N,N'-diisopropylcarbodiimide (DIC) in dimethylformamide (DMF).All derivatives vitro screened against U-937 macrophages Plasmodium falciparum, Leishmania panamensis Trypanosoma cruzi protozoan parasites.The hemolytic activity was evaluated on human red blood cells (RBC).Compounds N-(4-hydroxy-3,5-diiodophenethyl)-4-methylbenzamide...
Objetivos: Sintetizar conjugados del acetonido de la uridina con triterpenos (colesterol y 3 β -5 α ,8 -endoperoxido-colest-6-en-3-ol) acido succinico como puente. Metodos: Se preparo el en acetona mediante catalisis acida. prepararon los succinatos esteroles anhidrido catalizador nucleofilico 4-N,N-dimetilamino-piridina (DMAP). Los 1 2 se sintetizaron esterificacion Steglich, agente acoplamiento N,N’-diciclohexilcarbodiimida (DCC)y DMAP. compuestos caracterizaron por espectroscopia RMN ( H...
Objetivos: Sintetizar conjugados del acetónido de la uridina con triterpenos (colesterol y 3β-5α,8α-endoperoxido-colest-6-en-3-ol) ácido succínico como puente. Métodos: Se preparó el en acetona mediante catálisis ácida. prepararon los succinatos esteroles anhídrido catalizador nucleofílico 4-N,N-dimetilamino-piridina (DMAP). Los 1 2 se sintetizaron esterificación Steglich, agente acoplamiento N,N’-diciclohexilcarbodiimida (DCC)y DMAP. compuestos caracterizaron por espectroscopia RMN (1H 13C...
The upsurge and persistence of drug resistant strains Mycobacterium tuberculosis (Mtb) is an important limitant to the battery drugs available for elimination (TB). To avoid future scarcity antibiotics against Mtb, it discover new effective anti-mycobacterial agents. In this study, we present data from a series experiments determine in vitro vivo activity library epidioxy-sterol analogs. We test 15 compounds their ability reduce viability Mtb. found that one compound called T5...