A5036032833- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Cancer survivorship and care
- Cancer Research and Treatments
- Mobile Health and mHealth Applications
- Palliative Care and End-of-Life Issues
- Digital Mental Health Interventions
- Lanthanide and Transition Metal Complexes
- Family Support in Illness
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Advanced Biosensing Techniques and Applications
- Childhood Cancer Survivors' Quality of Life
- Virus-based gene therapy research
- Systemic Sclerosis and Related Diseases
- Gold and Silver Nanoparticles Synthesis and Applications
- Photodynamic Therapy Research Studies
- Technology Use by Older Adults
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Viral Infections and Outbreaks Research
- Health Literacy and Information Accessibility
- Glycosylation and Glycoproteins Research
Albemarle (United States)
2018-2024
Stanford University
2012-2020
Howard Hughes Medical Institute
2009-2015
National Institutes of Health
2008-2014
National Cancer Institute
2007-2013
Center for Cancer Research
2009-2013
Mayo Clinic in Arizona
2012
Wills Eye Hospital
2011
Thomas Jefferson University
2011
University of New Mexico
2007-2009
Abstract Purpose: Human tumors consist of heterogeneous populations cells with distinct marker expression and functional properties. In squamous cell carcinoma the head neck (SCCHN), CD44 is a well-characterized resilient subpopulation associated increased tumorigenesis, radioresistance, chemoresistance. Evidence indicates that these have an immunosuppressive phenotype; however, mechanisms been elusive. Experimental Design: Using primary human SCCHN tumor samples patient-derived xenografts,...
Near infrared fluorescence-guidance can be used for the detection of small cancer metastases and aid in endoscopic management cancer. Indocyanine green (ICG) is a Food Drug Administration (FDA)-approved fluorescence agent. Through non-specific interactions with serum proteins, ICG achieves enhanced permeability retention (EPR) effects. Yet, demonstrates rapid clearance from circulation. Therefore, may an ideal contrast agent real-time imaging tumors. To evaluate usefulness dual white light...
In vivo molecularly targeted fluorescence imaging of tumors has been proposed as a strategy for improving cancer detection and management. Activatable fluorophores, which increased their by 10-fold after binding tumor cells, result in much higher target to background ratios than conventional fluorophores. We developed an activatable optical probe based on fluorophore−quencher pair, bound targeting moiety. With this system, is quenched the interaction outside but activated within cells...
Optical imaging has the potential to improve efficacy of surgical and endoscopic approaches cancer treatment; however, optimal type fluorescent probe not yet been established. It is well-known that rhodamine-core-derived fluorophores offer a combination desirable properties such as good photostability, high extinction coefficient, fluorescence quantum yield. However, despite ubiquitous use rhodamine for in vivo optical imaging, it remains be determined if unique chemical among individual...
Abstract Systemic sclerosis (SSc) is a disease at the intersection of autoimmunity and fibrosis. However, epigenetic regulation contributions diverse cell types to SSc remain unclear. Here we survey, using ATAC-seq, active DNA regulatory elements eight primary cells in normal skin from healthy controls, as well clinically affected unaffected patients. We find that accessible skin-resident dendritic (DCs) exhibit highest enrichment SSc-associated single-nucleotide polymorphisms (SNPs) predict...
One of the primary goals oncological molecular imaging is to accurately identify and characterize malignant tissues in vivo . Currently, relies on targeting a single molecule that while overexpressed malignancy, often also expressed at lower levels normal tissue, resulting reduced tumor background ratios. approach increasing specificity cancer use multiple probes each with distinct fluorescence target several surface antigens simultaneously, order tissue expression profiles, rather than...
We present a method to reintroduce ophthalmic training into the medical school curriculum.To evaluate knowledge and skills acquired when participating in service project, Community Vision Project, develop quantitative for testing with direct ophthalmoscope patients.Second-year students participated study. After 1 month, their was compared that of peers graduates (internal medicine residents). Also at were those upperclassmen who had completed all core clerkships. One year later, after...
Filamentous phage display has been extensively used to select proteins with binding properties of specific interest.Although many different platforms using filamentous have described, no comprehensive comparison their abilities similar conducted.This is particularly important for the cytoplasmic proteins, which are often poorly displayed standard vectors.In this article, we analyzed ability a stable form green fluorescent protein and modified variants in nine vectors, number previously...
Commonly used in flow cytometry, multiplexed optical probes can diagnose multiple types of cell surface marker, potentially leading to improved diagnosis accuracy vivo. Herein, we demonstrate the targeting two different tumor markers models disseminated ovarian cancer. Two cancer lines (SKOV3 and SHIN3) were employed; both overexpress D-galactose receptor (D-galR), but only SKOV3 overexpresses HER2/neu. Additionally, fusion tumors composed SHIN3/RFP evaluated. Both galactosyl serum...
Maintaining user engagement with mobile health (mHealth) apps can be a challenge. Previously, we developed conceptual model to optimize patient in mHealth by incorporating multiple evidence-based methods, including increasing literacy, enhancing technical competence, and improving feelings about participation clinical trials. This viewpoint aims report on series of exploratory mini-experiments demonstrating the feasibility testing our previously published model. We collected data from 6...
Background Approximately 6.1 million adults in the United States serve as care partners for cancer survivors. Studies have demonstrated that engaging survivors and their through technology-enabled structured symptom collection has several benefits. Given high utilization of mobile technologies, even among underserved populations low resource areas, apps may provide a meaningful access point all stakeholders management. Objective We aimed to develop app incorporating user preferences enable...
Cutaneous small vessel vasculitis (CSVV) is a nonspecific finding with an extensive differential diagnosis. It critically important to distinguish skin-limited presentations of CSVV from severe life-threatening systemic vasculitides presenting as initial manifestation. can be challenging determine which patients are at risk for disease. Standard histopathologic evaluation, direct immunofluorescence, and serologic evaluation typically required exclude vasculitis. Type 1 cryoglobulinemia may...
Background: Nerve involvement developed in a patient with granuloma annulare, as evidenced by perineural infiltrate of histiocytes the dermis. The histopathologic pattern was suggestive leprosy. No mycobacteria were observed, and neurologic testing normal. Objective: To determine whether inflammation nerves or tissue is common we studied cutaneous skin biopsy specimens from 14 patients annulare. Methods: Sections stained hematoxylin-eosin to highlight inflammatory cells S-100 identify...