Clove (Eugenia caryophyllata Thunb. [Myrtaceae]) essential oil (CEO) has been shown to possess antimicrobial, antifungal, antiviral, antioxidant, anti-inflammatory and anticancer properties. However, few studies have focused on its topical use.We investigated the biological activity of a commercially available CEO in human skin disease model.We evaluated effect 17 protein biomarkers that play critical roles inflammation tissue remodelling validated dermal fibroblast system, which was...

The effect of cinnamon ( Cinnamomum zeylanicum ) bark essential oil (CBEO) on human skin cells has not been elucidated. Therefore, we investigated the activity a commercially available CBEO in validated dermal fibroblast system, model chronic inflammation and fibrosis. We first evaluated impact 17 protein biomarkers that play critical roles tissue remodeling. genome‐wide gene expression was also evaluated. showed strong anti‐proliferative effects significantly inhibited production several...

The use of oregano (Origanum vulgare) essential oil (OEO) has become popular in skin care products. However, scientific research regarding its effects on human cells is scarce. In this study, we investigated the biological activity a commercially available OEO, which high carvacrol content, cell disease model. OEO induced marked antiproliferative and significantly inhibited several inflammatory biomarkers, including monocyte chemoattractant protein 1 (MCP-1), vascular adhesion molecule...

Research on the biological effects of essential oils human skin cells is scarce. In current study, we primarily explored activities 10 (nine single and one blend) in a pre-inflamed dermal fibroblast system that simulated chronic inflammation. We measured levels proteins critical for inflammation, immune responses, tissue-remodeling processes. The nine were distilled from Citrus bergamia (bergamot), Coriandrum sativum (cilantro), Pelargonium graveolens (geranium), Helichrysum italicum...

Lemongrass (

Mental health issues have been increasingly recognized as public problems globally. Their burden is projected to increase over the next several decades. Additional therapies for mental are in urgent need worldwide due limitations and costs of existing healthcare approaches. Essential oil aromatherapy can provide a cost‐effective safe treatment many problems. This pilot study observed effects bergamot essential inhalation on well‐being, measured by Positive Negative Affect Scale,...

Although frankincense essential oil (FREO) has become increasingly popular in skin care, research on its biological activities human cells is scarce, if not completely absent. In the current study, we explored of FREO pre-inflamed dermal fibroblasts by analyzing levels 17 important protein biomarkers pertinent to inflammation and tissue remodeling. exhibited robust anti-proliferative activity these cells. It also significantly inhibited collagen III, interferon gamma-induced 10,...

ABSTRACT The serine chemoreceptor of Escherichia coli contains four canonical methylation sites for sensory adaptation that lie near intersubunit helix interfaces the Tsr homodimer. An unexplored fifth site, E502, lies at an intrasubunit interface closest to HAMP domain controls input-output signaling in methyl-accepting chemotaxis proteins. We analyzed, with vivo Förster resonance energy transfer (FRET) kinase assays, thresholds and response cooperativities receptors different mutationally...

: Natural killer (NK) cells are important immune system effector providing innate defenses against intracellular infections, including viral surveillance, and cancer immunoediting. The primary purpose of this study was to investigate whether modified ultra-filtrated colostrum (UC) hydrolyzed whey (W) products or their combinations with other natural reported immunomodulatory properties will stimulate NK cell cytotoxic activity by activation granzyme B IFN-γ production. ability the...

Although juniper (Juniperus communis) berry essential oil (JEO) has been used in skin care products, research on its biological activity human cells is scarce. In the current study, we explored of JEO (with alpha-pinene as major active component) pre-inflamed dermal fibroblasts, which were designed to mimic disease biology chronic inflammation and fibrosis. We analyzed levels 17 important protein biomarkers pertinent tissue remodeling. exhibited robust antiproliferative significantly...

In the current study, we examined biological activities of an essential oil blend (EOB) in validated human cell cultures, which model molecular biology autoimmune diseases and chronic inflammation. EOB is primarily composed oils from wild orange, clove, cinnamon, eucalyptus, rosemary. These disease models allow measurement changes protein biomarkers induced by treatment. Four T systems one skin system were used for biomarker analysis. Biomarkers levels measured both before after treatment...

Arborvitae (Thuja plicata) essential oil (AEO) is becoming increasingly popular in skincare, although its biological activity human skin cells has not been investigated. Therefore, we sought to study AEO's effect on 17 important protein biomarkers that are closely related inflammation and tissue remodeling by using a pre-inflamed dermal fibroblast culture model. AEO significantly inhibited the expression of vascular cell adhesion molecule 1 (VCAM-1), intracellular (ICAM-1), interferon...

Vetiver (Vetiveria zizanioides) essential oil (VEO) has a long history of use. However, research on its biological activity in human skin cells is scarce. In this study, we investigated the VEO pre-inflamed dermal fibroblast model, which was designed to mimic disease biology chronic inflammation and fibrosis. We analyzed impact levels 17 important protein biomarkers pertinent immune response tissue remodeling. exhibited strong antiproliferative these significantly inhibited production...

Aging has been increasingly recognized as a global health burden. Current aging research suggests that preventative strategies may increase both lifespan and healthspan. Many natural compounds or products have demonstrated promising antiaging benefits gained popularity in research. The present study evaluated two compositions comprised of nicotinamide mononucleotide, quercetin, alpha ketoglutarate, white button mushroom extract (standardized to spermidine), Transfer Factor (extracts from cow...

Cardamom (Elettaria cardamomum) essential oil (CEO) is popular in skin care, although no studies have reported its biological activity human cells. We studied effect on 17 protein biomarkers closely related to inflammation, immune responses, and tissue remodeling using a dermal fibroblast cell culture system designed model chronic inflammation. CEO significantly inhibited the proliferation of cells expression vascular adhesion molecule 1 (VCAM-1) macrophage colonystimulating factor (M-CSF)....

This study was designed to quantitatively evaluate the health benefits of a multivitamin, multimineral, herbal, essential oil–infused supplement using serum biomarkers. We also qualitatively evaluated effects this survey. Sixteen participants were recruited take as directed for two months. The levels following components measured in participants: total cholesterol, high-density lipoprotein (HDL) low-density (LDL) triglycerides, lipoprotein(a), LDL/HDL cholesterol ratio, total/HDL ferritin,...

Sleep disorders are associated with an elevated risk of developing various diseases. Herbal supplementation has been shown to alleviate sleep such as insomnia. Here, the effect on quality herbal supplement was evaluated subjectively. The primarily contained lavender essential oil, well L-theanine and extracts lemon balm, passion flower, chamomile. Fifty-one healthy adults self-reported symptoms insomnia, divided into placebo treatment groups, completed a 6-week crossover study (1-week...

Very few studies have investigated the biological activities of black pepper essential oil (BPEO) in human cells. Therefore, current study, we examined BPEO cytokine‐stimulated dermal fibroblasts by analyzing levels 17 important protein biomarkers pertinent to inflammation and tissue remodeling. exhibited significant antiproliferative activity these skin cells significantly inhibited production Collagen I, III, plasminogen activator inhibitor 1. In addition, studied effect on regulation...

This study evaluated the impact of bovine colostrum products, whey product, or their combinations with other natural products on human Peripheral Blood Mononuclear Cell (PBMC) ability to produce cytokines upon activation. PBMCs were pretreated ultrafiltered (UC), nano-filtered (NC), egg yolk extract (E), a botanical blend (B), + (CE), (CEB), and fermented (W) then stimulated lipopolysaccharide (LPS) phytohemagglutinin (PHA) activate T cells. Cytokine production was measured by Luminex assay....

Skin dryness, fine lines and wrinkles, red spots, vasculature, porphyrin count are common indicators of skin health beauty. The skincare system in this study contains scientifically validated ingredients such as fermented green tea (Camellia sinensis) water, niacinamide, antioxidants, a variety natural plant extracts. purpose was to evaluate the effectiveness improving facial-skin Twenty-six healthy adults, both female male, aged 18–54 all types tones, were included participated either...

The increasing popularity of essential oils for skincare has led to investigation their biological effects in human skin cells. In this study, we investigated the activities three commercially available oils, i.e. rosemary oil, wild orange and a blend (commercial name: Deep Blue) composed from wintergreen, camphor, peppermint, blue tansy, German chamomile, Helichrysum, Osmanthus, pre-inflamed dermal fibroblast culture model, simulating chronic inflammation. impact on proteins associated with...

Melaleuca (Melaleuca alternifolia) essential oil (MEO), commonly known as tea tree oil, is popularly used in skincare products. In the current study, we investigated biological activity of a commercially available MEO (with terpinen-4-ol major active component) pre-inflamed human dermal fibroblasts, which were designed to simulate chronic inflammation. We analyzed levels seventeen biomarkers that are important inflammation and tissue remodeling. Additionally, studied effect on genome-wide...

Significance Escherichia coli cells track chemical gradients with high sensitivity over a wide dynamic range, using feedback-controlled sensory adaptation system. CheR, receptor methyltransferase, is key component of the We discovered that CheR can enhance response chemoreceptor molecules, role opposes known signaling consequences its catalytic activity. This enhancement effect requires CheR-receptor binding interactions, but quantitatively inconsistent simple equilibrium mechanism. Rather,...