A5016458226- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Biochemical Analysis and Sensing Techniques
- Psychedelics and Drug Studies
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Cannabis and Cannabinoid Research
McGill University
2018-2021
Concordia University
2019-2021
Significance Social behavior (SB) is a fundamental hallmark of human interaction. Repeated administration low doses the 5-HT 2A agonist lysergic acid diethylamide (LSD) in mice enhances SB by potentiating and AMPA receptor neurotransmission mPFC via an increasing phosphorylation mTORC1, protein involved modulation SB. Moreover, inactivation glutamate impairs nullifies prosocial effects LSD. Finally, LSD requires integrity mTORC1 excitatory glutamatergic, but not inhibitory neurons, to...
The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but circuit mechanisms are unclear. Recent evidence suggests that amygdala thalamic inputs exert opposing control over behavior, much like direct indirect pathway output neurons. Accordingly, opponent processes between these NAc or cell types may underlie efficient reward seeking. We assess the contributions of elements mouse operant behavior during recurring conditions when is not available. Although...
Archaerhodopsin (ArchT)-mediated photoinhibition of axon terminals is commonly used to test the involvement specific long-range neural projections in behavior. Although sustained activation this opsin has unintended consequence enhancing spontaneous vesicle release, it unclear whether desynchronized signaling consequential for ArchT's behavioral effects. Here, we compare terminal and cell body nucleus accumbens (NAc) afferents utility these approaches uncovering pathway-specific...
Cue-evoked midbrain dopamine (DA) neuron activity reflects expected value, but its influence on reward assessment is unclear. In mice performing a trial-based operant task, we test if bidirectional manipulations of cue or operant-associated DA drive learning as result under- overexpectation value. We target optogenetic to different components forced trials, when only one lever presented, and assess biases choice trials in the absence photomanipulation. Although are demonstrated be flexible...