A5017529012- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Comparative constitutional jurisprudence studies
- Osteoarthritis Treatment and Mechanisms
- Protease and Inhibitor Mechanisms
- Cancer Research and Treatments
- Radical Photochemical Reactions
- Human Rights and Immigration
- European history and politics
- Historical Studies in Latin America
- Immune Response and Inflammation
- Organoboron and organosilicon chemistry
- HER2/EGFR in Cancer Research
- Melanoma and MAPK Pathways
- Tendon Structure and Treatment
- Political Theory and Democracy
- International Environmental Law and Policies
- Sphingolipid Metabolism and Signaling
- Advanced Glycation End Products research
- CAR-T cell therapy research
- Blood Coagulation and Thrombosis Mechanisms
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Knee injuries and reconstruction techniques
- American Constitutional Law and Politics
Bayer (Germany)
2014-2021
German Federal Chancellery
2010
Junta de Castilla y León
2010
Bayer (United States)
2009
University of Baltimore
2007
Mount Sinai Hospital
2006
Lunenfeld-Tanenbaum Research Institute
2006
University Hospital Bonn
2005
RWTH Aachen University
1999-2002
Philipps University of Marburg
2001
Abstract Objective Matrix metalloproteinases (MMPs) have long been considered excellent targets for osteoarthritis (OA) treatment. However, clinical utility of broad‐spectrum MMP inhibitors developed this purpose has restricted by dose‐limiting musculoskeletal side effects observed in humans. This study was undertaken to identify a new class potent and selective MMP‐13 that would provide histologic efficacy without toxicity. Methods Selectivity assays were using catalytic domains human MMPs....
[reaction: see text] A new method for mild metal-free hydrosilylation is described. Silylated cyclohexadienes are used as radical transfer hydrosilylating reagents various double and triple bonds. trialkylsilane transferred from a cyclohexadiene moiety to an alkene. The can be combined with C-C bond formation shown the preparation of silylated cycloalkanes corresponding dienes.
Abstract The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of IL-6-type cytokines. extracellular part predicted to consist six individual domains. Whereas role three membrane-distal domains (D1–D3) in binding IL-6 and IL-11 well established, function membrane-proximal (D4–D6) unclear. Mapping a neutralizing mAb suggests functional D4–D6 activation. Individual deletion these differentially interferes with ligand soluble membrane-bound receptors. All...
gp130 is the common signal transducing receptor subunit of interleukin (IL)‐6‐type cytokines. either homodimerizes in response to IL‐6 and IL‐11 or forms heterodimers with leukemia inhibitory factor (LIF) (LIFR) LIF, oncostatin M (OSM), ciliary neurotrophic (CNTF), cardiotrophin‐1 (CT‐1) cardiotrophin‐like cytokine resulting onset cytoplasmic tyrosine phosphorylation cascades. The extracellular parts both LIFR consist several Ig‐like fibronectin type III‐like domains. role membrane‐distal...
Leukaemia inhibitory factor (LIF) signals via a heterodimeric receptor complex comprised of the LIF (LIFR) and interleukin (IL)-6 signal transducer gp130. Upon binding to its cognate is internalized. In this study, we show that LIFR endocytosed independently By using heterochimaeric system identified dileucine-based internalization motif within cytoplasmic domain LIFR. Our findings suggest LIFR/gp130 homodimeric gp130/gp130 are distinct signals.
Gp130 is the common signal transducing receptor subunit of interleukin (IL)‐6, IL‐11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic and cardiotrophin‐1. IL‐6 IL‐11 induce gp130 homodimerization whereas others lead to formation heterodimers with LIFR or OSMR. Binding epitopes for are located in immunoglobulin‐like domain cytokine binding module (CBM). Here we show that a mutant lacking 1, although unresponsive can still activate transducer activator transcription...
Leukaemia inhibitory factor (LIF) signals via a heterodimeric receptor complex comprised of the LIF (LIFR) and interleukin (IL)-6 signal transducer gp130. Upon binding to its cognate is internalized. In this study, we show that LIFR endocytosed independently By using heterochimaeric system identified dileucine-based internalization motif within cytoplasmic domain LIFR. Our findings suggest LIFR/gp130 homodimeric gp130/gp130 are distinct signals.
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Abstract Cancer cells typically display altered glucose metabolism characterized by a preference of aerobic glycolysis (Warburg effect) resulting in higher levels glycolytic waste including methylglyoxal (MG). GLO1 (Glyoxalase 1) functions the detoxification MG: MG reacts with glutathione to form hemithioacetal, which is converted into S-D-Lactoylglutathione and further metabolised D-lactate GLO2. When not detoxified, acts as cytotoxic reagent forming DNA- protein-adducts (advanced glycation...
"Law and Politics in Africa, Asia Latin America" analyses legal constitutional developments all states or regions outside of Europe as well their regional international integration. Founded 1968 inspired by decolonization the idea a cooperative new beginning, Journal also promotes special interest contributions on 'Law development'. The journal aims to provide forum for variety perspectives these fields interest, be they focused one country comparative, theoretical methodological nature.
Einleitung: Dendritische Zellen können antigenspezifische T-Zellen gegen Tumorantigene stark stimulieren. Ihr Ansatz das hepatozelluläre Karzinom (HCC) hat allerdings bisher nur begrenzten Erfolg gezeigt. Die Verwendung von potenten Immunmodulatoren wie CD40L könnte die antitumorale Wirkung DC HCC steigern. Unser Ziel in dieser Arbeit war zu prüfen, ob sich immunstimulatorische mit Tumorlysat beladenen mittels Transduktion CD40L-Adenovirus verstärken lässt.