A5102882950- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Flame retardant materials and properties
- Biofuel production and bioconversion
- Energetic Materials and Combustion
- Fire dynamics and safety research
- Biodiesel Production and Applications
- Asymmetric Hydrogenation and Catalysis
- Influenza Virus Research Studies
- Lignin and Wood Chemistry
- Enzyme Catalysis and Immobilization
- Carbohydrate Chemistry and Synthesis
- Electrohydrodynamics and Fluid Dynamics
- Proteins in Food Systems
- Microbial Metabolic Engineering and Bioproduction
- Innovative Microfluidic and Catalytic Techniques Innovation
- Respiratory viral infections research
- Axial and Atropisomeric Chirality Synthesis
- Quinazolinone synthesis and applications
- Engineering Applied Research
- Botanical Research and Applications
- Peroxisome Proliferator-Activated Receptors
- Pickering emulsions and particle stabilization
- Adsorption, diffusion, and thermodynamic properties of materials
Southwest Petroleum University
2008-2024
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2021-2022
Vertex Pharmaceuticals (United States)
2014-2021
Huaibei Mining (China)
2007
Boston College
2002-2006
University of California, Santa Cruz
1998-2002
In our effort to develop agents for the treatment of influenza, a phenotypic screening approach utilizing cell protection assay identified series azaindole based inhibitors cap-snatching function PB2 subunit influenza A viral polymerase complex. Using bDNA replication (Wagaman, P. C., Leong, M. A., and Simmen, K. A. Development novel antiviral assay. J. Virol. Methods 2002, 105, 105-114) in cells as direct measure activity, we discovered set cyclohexyl carboxylic acid analogues, highlighted...
Abstract Objective Matrix metalloproteinases (MMPs) have long been considered excellent targets for osteoarthritis (OA) treatment. However, clinical utility of broad‐spectrum MMP inhibitors developed this purpose has restricted by dose‐limiting musculoskeletal side effects observed in humans. This study was undertaken to identify a new class potent and selective MMP‐13 that would provide histologic efficacy without toxicity. Methods Selectivity assays were using catalytic domains human MMPs....
A convergent diastereo- and enantioselective total synthesis of anti-HIV agent chloropeptin I is reported. Important features the include: (1) use Ti-catalyzed cyanide addition to imines prepare a requisite amino acid moiety, (2) discovery positive effect MeOH in Cu-mediated biaryl ether formation afford one two macrocyclic peptide moieties, (3) influence collidine diastereoselective Pd-mediated cross-coupling result efficient another macrocycle within this medicinally important molecule....
An Al-catalyzed enantioselective method for additions of Me2Zn and Et2Zn to α-ketoesters bearing aromatic, alkenyl, alkyl substituents is disclosed. Transformations are promoted in the presence a readily available amino acid-based ligand afford desired products excellent yields up 95% ee. Investigations described illustrate that Lewis basic additive can lead significant enhancements efficiency enantioselectivity. A mechanistic model provides rationale such effects provided.
This work combines guanidine dihydrogen phosphate (GDP) and zinc borate (ZB) to modify wood via microwave-ultrasonic impregnation for realizing favorable flame retardancy thermal stability, which were investigated by the limiting oxygen index (LOI), thermogravimetric analysis (TGA), cone calorimetry tests (CONE). The treated samples show better performance in fire with LOI value increasing 47.8%, results of TGA indicate outstanding stability wood. In addition, decline heat release rate,...
Recently, widespread concern has been aroused on environmentally friendly materials. In this article, barium phytate (Pa-Ba) was prepared by the reaction of phytic acid with carbonate in deionized water, which used to blend intumescent flame retardant (IFR) as a and added epoxy resin (EP). Afterward, chemical structure thermal stability Pa-Ba were characterized Fourier transform infrared (FTIR) spectroscopy thermogravimetric analysis (TGA), respectively. On basis, flammability retardancy EP...
Here, we report a controllable strategy for fabricating monodispersed microspheres composed of poly(butyl methacrylate) (BMA) and silane-modified Cu/Ni-embedded metal-organic framework (MOF)-TiO₂ composites (denoted as BMA@Cu/Ni@MOF-TiO₂ microsphere) efficient photocatalytic degradation....
The reaction of lead(IV) 4-indolyl triacetate with substituted methyl 2-oxo-1-cyclohexanecarboxylates has been investigated as a route to the natural product N-methylwelsitindolinone C isothiocyanate. Reaction reagent 18 beta-ketoester 20 affords desired coupled material in excellent yield and diastereoselectivity. Reaction: see text.
A Pd-mediated method for preparation of the strained macrocyclic moiety complestatins is disclosed. Through stereoselective synthesis model macrocycles and S atropisomer complestatin, stereochemical identity anti-HIV agent complestatin established. Investigations described herein illustrate that compound previously reported as isocomplestatin same complestatin. Thus, true has not been isolated a natural product.
In our efforts to develop novel small-molecule inhibitors for the treatment of influenza, we utilized molecular modeling and X-ray crystal structure PB2 subunit influenza polymerase optimize a series acyclic β-amino acid inhibitors, highlighted by compound 4. Compound 4 showed good oral exposure in both rat mouse. More importantly, it strong potency versus multiple influenza-A strains, including pandemic 2009 H1N1 avian H5N1 strains efficacy profile mouse model even when was initiated 48 h...
A cyclohexanone intermediate to be employed in the synthesis of marine natural product N-methylwelwitindolinone C isothiocyanate has been prepared. The is diastereoselective for production C12 quaternary center, which obtained via a conjugate addition reaction directed by an adjacent chiral, nonracemic ketal. single crystal X-ray analysis derivative final established absolute stereochemistry at C12.
Von Peptiden abgeleitete chirale Liganden fördern die Al-katalysierte enantioselektive Addition von Trimethylsilylcyanid an aromatische und aliphatische, cyclische acyclische Ketone (Beispiel siehe Schema). Sie sind einfach herzustellen, werden leicht wiedergewonnen lassen sich ohne Aktivitäts- oder Selektivitätsverlust erneut einsetzen.
Citral is a typical UV-irritation and acid-sensitive active here we develop mild method for the encapsulation of citral in calcium alginate microcapsules, which UV irritation or acetic acid avoided. Monodispersed oil-in-water-in-oil (O/W/O) emulsions are generated capillary microfluidic device as precursors. The middle aqueous phase O/W/O contains sodium alginate, calcium-ethylenediaminetetraacetic (EDTA-Ca) complex source, D-(+)-Gluconic δ-lactone (GDL) acidifier. Hydrolysis GDL will...
In our efforts to identify novel small molecule inhibitors for the treatment of adrenoleukodystrophy (ALD), we conducted a high-throughput radiometric screen elongation very long chain fatty acid 1 (ELOVL1) enzyme. We developed series highly potent, central nervous system (CNS)-penetrant pyrimidine ether-based compounds with favorable pharmacokinetics culminating in compound 22. Compound 22 is selective inhibitor ELOVL1, reducing C26:0 VLCFA synthesis ALD patient fibroblasts and lymphocytes...
BACKGROUND Recovering high value-added substances (oil, zein and carotenoids) from corn distillers dried grains with solubles (DDGS), the major coproduct of bioethanol, is important to enhance profit ethanol process. Currently, few studies have been reported on separating in a process suitable for industrialization. In this article, semi-continuous countercurrent extraction method was investigated refine DDGS. RESULTS First, an oil yield as 94.5% (based content DDGS) measured using series...