A5071191675- Aluminum Alloys Composites Properties
- Magnesium Alloys: Properties and Applications
- Electronic Packaging and Soldering Technologies
- Mechanical Behavior of Composites
- Aluminum Alloy Microstructure Properties
- 3D IC and TSV technologies
- Corrosion Behavior and Inhibition
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Biosimilars and Bioanalytical Methods
- Process Optimization and Integration
- Advanced Welding Techniques Analysis
- Analytical Chemistry and Chromatography
- Spectroscopy and Laser Applications
- Tribology and Wear Analysis
- Fatigue and fracture mechanics
- Adhesion, Friction, and Surface Interactions
- High Temperature Alloys and Creep
- Total Knee Arthroplasty Outcomes
- Mass Spectrometry Techniques and Applications
- Advanced Control Systems Optimization
- Microstructure and mechanical properties
- Lower Extremity Biomechanics and Pathologies
- Carbon Dioxide Capture Technologies
- Mechanical stress and fatigue analysis
Dalian Jiaotong University
2007-2025
Tianjin University
2015-2024
Vertex Pharmaceuticals (United States)
2010-2024
Tianjin Special Equipment Supervision and Inspection Technology Research Institute
2021-2024
Shandong Iron and Steel Group (China)
2021
South China Agricultural University
2012-2021
Anhui Polytechnic University
2016-2021
Zhengzhou University of Light Industry
2011-2019
China University of Petroleum, Beijing
2015-2017
Beihang University
2013
Twenty-nine derivatives of berberine (1) or pseudoberberine (2) were designed, semisynthesized, and evaluated for their up-regulatory activity on the low-density-lipoprotein receptor (LDLR) expression. SAR analysis revealed that (i) methylenedioxy group at 2- 3-position is an essential element to keep activity, (ii) 7-position quaternary ammonium planar structure compound are activity-required, (iii) addition electron-donating groups 7- 13-position reduced activity. Of 1 analogues, 2...
Magnesium alloys have better biocompatibility and biodegradability than conventional biomedical metal materials, but the corrosion resistance is so poor that implant loses its mechanical integrity before damaged tissue completely recovers. In this study, ZEK100 magnesium alloy was pre-deformed with a high-pressure torsion (HPT) process then fabricated hydroxyapatite (HA) coatings different contents of Mg(OH)2 nanopowder via hydrothermal method. The specimens were characterized by scanning...
The energy recovery integrated machine can effectively reduce the consumption of a seawater desalination system by harnessing residual pressure in high-pressure waste liquid. However, axial force imbalance between pump side and turbine lead to sliding rotor system, then change clearance size. objective this paper is investigate unsteady flow pattern with sliding, focusing specifically on under coupled operation conditions. results show that increased size performance decreases obviously but...
Combining large-sized flaky alumina and spherical as thermally conductive fillers in thermal management materials can effectively establish heat-conducting pathways significantly increase the system’s heat conduction value. Conventional preparation processes typically produce with a small size low diameter-to-thickness ratio, often failing to meet requirements for applications fillers. By combining conventional molten salt method gas-phase fluoride ions, this study produced large-sized,...
Background: A frequent impediment to accurate quantitation in bioanalytical LC–MS arises from carryover. For many new chemical entities drug discovery carryover is not limited the autosampler, but instead several different sources. Method: We tested columns, injector wash sequences and gradient compositions understand eliminate these In instances was dictated by elution column as much autosampler hardware protocol. Conclusion: Several trends were observed. First, columns resulted...
Aim: Volumetric absorptive microsampler (VAMS) was designed to sample a fixed volume of blood regardless the hematocrit (HCT) levels. Model compounds with wide range hydrophobicity were evaluated for their extraction recoveries from VAMS dried samples. Results: For highly hydrophobic compounds, methanol or methanol/acetonitrile higher compared using aqueous mixture acetonitrile. Extraction (1:1) yielded more consistent recovery across HCT 20–70% than alone, good linearity, accuracy and...
A general method for determining bacterial uptake of compounds independent antibacterial activity would be a valuable tool in drug discovery. LC-MS/MS assays have been described, but it has not shown whether the data can used directly to inform medicinal chemistry. We describe evaluation an assay measuring association with bacteria, using set over hundred (inhibitors NAD-dependent DNA ligase, LigA) which vitro potency and had determined. All were active against efflux-deficient strain...
The strong anisotropy of magnesium alloy affects both its corrosion and fatigue performance by orientation, it is important to investigate the effect orientations on two properties for development in biomedical field. In this paper, through experiments corroded specimens, differences resistance failure ZK60 with different were investigated, mechanism these was analyzed. terms performance, compared RN surface, RT surface higher atomic arrangement density has a lower rate resistance. addition,...