A5103233941- CAR-T cell therapy research
- Biomedical and Engineering Education
- Veterinary Pharmacology and Anesthesia
- 3D Printing in Biomedical Research
- Marine and Offshore Engineering Studies
- Offshore Engineering and Technologies
- Biomedical Ethics and Regulation
- Oil and Gas Production Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Animal testing and alternatives
- Advanced Combustion Engine Technologies
- Mechanical Engineering and Vibrations Research
- Cephalopods and Marine Biology
- Animal Behavior and Welfare Studies
- Meat and Animal Product Quality
- CRISPR and Genetic Engineering
- Sarcoma Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Reconstructive Surgery and Microvascular Techniques
- Phagocytosis and Immune Regulation
- Abdominal Surgery and Complications
- Human-Animal Interaction Studies
- Animal Nutrition and Health
- Construction Engineering and Safety
- Injury Epidemiology and Prevention
St. Luke's University Health Network
2024
State University of New York
2022
SUNY Downstate Health Sciences University
2022
Universities Federation for Animal Welfare
2014-2018
Progenitor Cell Therapy (United States)
2017
Lonza (United States)
2011-2016
Walker (United States)
2011-2016
ExxonMobil (Germany)
2012-2015
Loughborough University
2001-2015
ExxonMobil (United States)
2004-2012
Abstract This article is the result of an initiative between European Federation Pharmaceutical Industries Associations (EFPIA) and Centre for Validation Alternative Methods (ECVAM). Its objectives are to provide researcher in safety evaluation laboratory with up‐to‐date, easy‐to‐use set data sheets aid study design process whilst at same time affording maximum welfare considerations experimental animals. Although this targeted researchers Industry, it considered that principles underpinning...
This paper is the result of an international initiative and a first attempt to develop guidelines for care welfare cephalopods (i.e. nautilus, cuttlefish, squid octopus) following inclusion this Class ∼700 known living invertebrate species in Directive 2010/63/EU. It aims provide information investigators, animal committees, facility managers staff which will assist improving both given cephalopods, manner experimental procedures are carried out. Topics covered include: implications...
Directive 2010/63/EU introduced requirements for the classification of severity procedures to be applied during project authorisation process use animals in scientific and also report actual experienced by each animal used such procedures. These offer opportunities design, conduct reporting consider adverse effects how these can reduced minimize welfare consequences animals. Better recording should help highlighting priorities refinement future similar benchmarking good practice. Reporting...
CD31 is a specific and sensitive marker of endothelial differentiation. Previous reports have described its immunoreactivity in large series soft tissue neoplasms, as well comparison with other available commonly used markers. reactivity carcinomas or mesotheliomas has been incompletely addressed, however. Hence, we applied anti-CD31 (JC70/A, DAKO, Carpinteria, Calif) to 290 previously characterized neoplasms by using modified avidin-biotin-peroxidase complex technique following microwave...
Abstract This paper provides an overview of the first documented industry intervention involving replacement a permanent mooring system due to seabed trenching near suction piles. Another unique aspect this was use readily available hardware for installing temporary minimize operational risks. Brown-field interventions are often required address integrity issues or life extensions. These more challenging than new (green-field) designs and installations existing infrastructure. includes...
Aims: Some allogeneic cell therapies requiring a high dose of cells for large indication groups demand change in expansion technology, from planar units to microcarriers single-use bioreactors the market phase. The aim was model optimal timing making this change. Materials & methods: A development lifecycle cash flow framework created examine implications process changes microcarrier cultures at different stages therapy's lifecycle. Results: analysis performed under assumptions used...
The translation of laboratory processes into scaled production systems suitable for manufacture is a significant challenge cell based therapies; in particular there lack analytical methods that are informative and efficient process control. Here the potential image analysis as one part solution to this issue explored, using pluripotent stem colonies valuable challenging exemplar. Cell-IQ live imaging platform was used build libraries morphological culture attributes such colony "edge," "core...
Drug product selection legislation is intended to achieve savings in the cost of prescription drugs without adversely affecting quality care by allowing pharmacists opportunity dispense less costly generically equivalent drug products place which had been prescribed physician. Various conditions under are authorized state laws exercise option substitute discussed. The study then identifies and examines may do occur, using Michigan as model. Over 60,000 actual prescriptions were examined for...
Abstract The paper will present the results of joint industry study into fatigue resistance large diameter anchor chain', and discuss interpretation results. represents largest body well documented corrosion tests on a variety different chain grades sizes. analysis & use available data, including life tested but un-failed Iinks, to determine suitable curves for mooring lines lengths. Many findings were be expected, based past there some surprises with respect grade. Fracture surface...
Abstract This paper provides a high level overview of various elements Mooring Risk Management Plan (MRMP). One or more the MRMP may be incorporated as part an overall Safety, Health and Environment (SHE) Plan. The can used for mooring integrity management to reduce operational risks. covers background, motivation, key elements, implementation strategy associated challenges. addresses steps operator take in proactive manner respond failure. issues are covered from pragmatic perspective,...
Abstract Granular cell tumors (GCTs) are rare, indolent neoplasms classically characterized by eosinophilic granular cytoplasm, infiltrations of polygonal cells in the collagenous stroma, and pustulo‐ovoid bodies Milian. We describe a case 10‐year‐old female presenting with GCT upper arm, remarkable for positive Melan‐A expression without additional melanocytic features. The differentiation between versus carries significant implications clinical management, such diagnoses should be...
Both quality of product and rapidity manufacture are critical parameters if ex vivo manufacturing autologous chimeric antigen receptor T cell (CAR-T) therapies is to reach its full potential. The Quantum Flex Cell Expansion System from Terumo Blood Technologies (Terumo BCT), a hollow-fiber bioreactor platform, one several expansion systems available gene therapy manufacturers generate such cells in GMP-compliant manner. In this study, the dynamic range platform expand CD19 CAR-T variable...