Lei Cao

ORCID: 0000-0003-2728-3023
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About
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Research Areas
  • Epigenetics and DNA Methylation
  • Hearing, Cochlea, Tinnitus, Genetics
  • Cancer Research and Treatments
  • Neurological Disease Mechanisms and Treatments
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Genetics and Neurodevelopmental Disorders
  • Dementia and Cognitive Impairment Research
  • Transcranial Magnetic Stimulation Studies
  • Marine animal studies overview
  • Advanced Glycation End Products research
  • Cognitive Abilities and Testing
  • Nanoplatforms for cancer theranostics
  • Functional Brain Connectivity Studies
  • Sirtuins and Resveratrol in Medicine
  • Gut microbiota and health
  • Cancer, Hypoxia, and Metabolism
  • Neurogenesis and neuroplasticity mechanisms
  • Biochemical Analysis and Sensing Techniques
  • Stroke Rehabilitation and Recovery
  • Ferroptosis and cancer prognosis
  • Connexins and lens biology
  • Immune Cell Function and Interaction
  • Antimicrobial Peptides and Activities
  • Heat shock proteins research
  • Genetics, Aging, and Longevity in Model Organisms

Xiamen University
2013-2025

Fujian University of Traditional Chinese Medicine
2023-2024

Wuhan No. 7 Hospital
2024

Nanjing Chest Hospital
2023

Gansu University of Traditional Chinese Medicine
2022

Dr. John T. Macdonald Foundation
2014

Huazhong University of Science and Technology
2011

Demyelinating diseases, such as multiple sclerosis, are known to result from acute or chronic injury the myelin sheath and inadequate remyelination; however, underlying molecular mechanisms remain unclear. Here, we performed genome occupancy analysis by chromatin immunoprecipitation sequencing in oligodendrocytes response lysolecithin-induced found that Olig2 its downstream target Gpr17 critical factors regulating oligodendrocyte survival. After oligodendrocytes, was significantly...

10.1523/jneurosci.0898-16.2016 article EN cc-by-nc-sa Journal of Neuroscience 2016-10-12

Significance Concerted action of thousands proteins is required for the inner ear to convert acoustic waves into electrical signals hearing. Many these are currently unknown. This study uses a genetic approach identify FAM65B as gene mutated in family with sensorineural hearing loss. Characterization shows that it component plasma membrane stereocilia hair bundle, essential organelle which originate ear. Thus, previously unrecognized crucial

10.1073/pnas.1401950111 article EN Proceedings of the National Academy of Sciences 2014-06-23

Purpose To verify the effects of multi-domain computerized cognitive training on intellectual function and adaptive functioning in children with developmental disorder (IDD). Methods Children IDD were randomized to a (CCT) group (n = 30) control 30). Both groups received 5-week program. Intellectual was assessed by Chinese-Wechsler Young scale (C-WYCSI) Chinese Vineland Adaptive Behavior Rating Scale (VABS-C), which used at baseline, post-training, 3-month follow-up. Results There...

10.3389/fpsyg.2022.1059889 article EN cc-by Frontiers in Psychology 2023-01-09

Background Although links between social networks and mild cognitive impairment (MCI) have been suggested. The pathway MCI from the Person-Environment-Occupation (PEO) model perspective among older adults remains inconclusive. Objective To examine relationship MCI, further identify whether neuropsychological factors mediate relationship. Methods 1036 participants aged 55 to 75 years were recruited two districts of Fuzhou, China, December 2020 2022. Data obtained via a face-to-face scale...

10.1177/13872877241299452 article EN other-oa Journal of Alzheimer s Disease 2024-11-25

Cervical cancer is the fourth most common among women worldwide, and its occurrence linked to a variety of factors, including human papillomavirus (HPV) infection, genetic predisposition, lifestyle composition host microbiome (Abu-Rustum et al., 2023). Recently, there has been growing body research that examines influence on microenvironment cervical cancer. The microbial ecology an intricate ecosystem, whereby Lactobacillus iners (L. iners) have notable impact. L. in vagina synthesizes...

10.3389/fcimb.2024.1469924 article EN cc-by Frontiers in Cellular and Infection Microbiology 2024-12-20

The impacts of natural plant extracts, including Lycium barbarum polysaccharides (LBP), mulberry leaf flavonoids (MLF), and ginkgo (GLF), on high glucose (HG)-induced injury in HBZY-1 mesangial cells were analyzed. LBP, MLF, GLF individually extracted, their purities determined. cultured low (LG) served as the Normal group (NG), while HG culture represented group. Subsequently, treated with 300 μ g/mL GLF, resulting HG+LBP, HG+MLF, HG+GLF groups, respectively. Cell viability (CV) was...

10.1166/sam.2024.4618 article EN Science of Advanced Materials 2024-03-01

OPINION article Front. Oncol., 28 April 2023Sec. Cancer Epidemiology and Prevention Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1143108

10.3389/fonc.2023.1143108 article EN cc-by Frontiers in Oncology 2023-04-28

The objective of this study was to analyze the influence long non-coding ribonucleic acid PGM5-AS1 on lung cancer cell ferroptosis through microrna-587. To end, research team has included abnormal expression vectors and microrna-587 were transfected into human line A549 detect alterations in activity, apoptosis, cycle, oxidative stress, iron ion ferroptosis-associated proteins. results show silencing or elevating promoted proliferation invasion, while inhibiting apoptosis resisting...

10.37290/ctnr2641-452x.22:213-221 article EN Current Topics in Nutraceutical Research 2023-10-23
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