A5008184434- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Hereditary Neurological Disorders
- Peripheral Neuropathies and Disorders
- Vascular Malformations Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Pituitary Gland Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Axon Guidance and Neuronal Signaling
- Multiple Sclerosis Research Studies
- Cerebrovascular and genetic disorders
- Prion Diseases and Protein Misfolding
- Alcoholism and Thiamine Deficiency
- Muscle Physiology and Disorders
- Ocular Oncology and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Hippo pathway signaling and YAP/TAZ
- Neurogenesis and neuroplasticity mechanisms
- Skin and Cellular Biology Research
- Neurological diseases and metabolism
- Autopsy Techniques and Outcomes
- Immunotoxicology and immune responses
- Diet and metabolism studies
Derriford Hospital
2012-2023
University Hospitals Plymouth NHS Trust
2013-2022
National Health Service
2021
Plymouth Hospital
2014-2017
Peninsula College of Medicine and Dentistry
2013-2015
Leeds General Infirmary
2006-2013
Torbay Hospital
2012
Leeds Teaching Hospitals NHS Trust
2008
Loss of the Merlin tumor suppressor and activation Hippo signaling pathway play major roles in control cell proliferation tumorigenesis. We have identified completely novel for effector Yes-associated protein (YAP) Schwann (SC) plasticity peripheral nerve repair after injury. Injury to nervous system (PNS) causes a dramatic shift SC molecular phenotype generation repair-competent SCs, which direct functional repair. find that loss these cells catastrophic failure axonal regeneration...
Schwannoma tumours typically arise on the eighth cranial nerve and are mostly caused by loss of tumour suppressor Merlin (NF2). There no approved chemotherapies for these surgical removal carries a high risk damage to or other close tissue. New treatments schwannoma NF2-null such as meningioma urgently required. Using combination human primary cells mouse models schwannoma, we have examined role Hippo signalling pathway in driving cell growth. both genetic ablation effectors YAP TAZ well...
Genetic factors have been suggested to be involved in the pathogenesis of sporadic inclusion body myositis (sIBM). Sequestosome 1 (SQSTM1) and valosin-containing protein (VCP) are 2 key genes associated with several neurodegenerative disorders but yet thoroughly investigated sIBM. A candidate gene analysis was conducted using whole-exome sequencing data from 181 sIBM patients, whole-transcriptome expression performed patients genetic variants interest. We identified 6 rare missense SQSTM1...
A minority of meningiomas are difficult to treat with surgery or radiotherapy, and chemotherapeutic alternatives limited. This study aims better understand pathways that active in meningiomas, order direct future treatment strategies. We investigated the expression activation multiple growth factor receptors, their ligands downstream signalling 30 using immunohistochemistry. Expression was correlated chromosome 22q loss. Membrane VEGF receptor (VEGFR) platelet-derived (PDGFR)β seen 83%...
Background: Successful treatment of glioblastoma (GBM) remains futile despite decades intense research. GBM is similar to most other malignant cancers in requiring glucose and glutamine for growth, regardless histological or genetic heterogeneity. Ketogenic metabolic therapy (KMT) a non-toxic nutritional intervention cancer management. We report the case 32-year-old man who presented 2014 with seizures right frontal lobe tumor on MRI. The cells were immunoreactive antibodies IDH1 (R132H)...
Loss of the Merlin tumour suppressor causes abnormal de-differentiation and proliferation Schwann cells formation schwannoma tumours in patients with neurofibromatosis type 2. Within mature peripheral nerve normal development, differentiation maintenance myelinating non-myelinating is regulated by a network transcription factors that include SOX10, OCT6 (now known as POU3F1), NFATC4 KROX20 (also Egr2). We have examined for first time how their regulation cell development disrupted primary...
Background/Aims: To evaluate the need for routine histopathological analysis of enucleated/eviscerated eyes and changes in indications eye removal. Methods: Retrospective review all enucleation/evisceration histopathology reports over 20 years. Clinical history was correlated with pathological findings. Two 10 year periods (1984–93, 1994–2003) were compared to detect Results: In total, 285 results traced from 1984 2003; 161 124 evisceration enucleation specimens, respectively. Glaucoma,...
Purpose. To know the occurrence and distribution of Pilomyxoid Astrocytomas amongst tumours previously diagnosed histologically as Pilocytic Astrocytoma to assess clinical impact this new entity. Methods. Retrospective Diagnostic review all cases WHO Grade I at a single Neurosurgical unit between 1990 2003. Results. Of total 91 identified, 9 were found have histology. these, 8 children (mean age 3.33 years) 1 adult. 6 hypothalamochiasmatic in location. The course was aggressive marked by...
Schwann cells myelinate axons of the peripheral nervous system. This process myelination is regulated by various transcription factors. c-Jun and Sox-2 are negative regulators control cell differentiation plasticity. Schwannoma within tumours no longer express myelin markers, show increased proliferation decreased apoptosis. We have shown previously that several signalling pathways activated in schwannoma situ, particular N-terminal kinase (JNK) pathway. Both vitro vivo we demonstrated...
We report a case of EBV+ and HHV-8+ multicentric Castleman disease with plasmablastic aggregates in an HIV-positive individual. A 41-year-old man presented early 2015 fevers, sweats, weight loss, intractable itching, on subsequent testing was found to be HIV positive. Investigations showed cervical lymphadenopathy splenomegaly. He treated for his symptoms resolved. His recurred January 2016, provisional diagnosis entertained. The HHV-8 (human herpesvirus-8) EBV (Epstein-Barr virus) viral...
"Thoraco-lumbar spontaneous ligamentum flavum haematoma." British Journal of Neurosurgery, 27(4), pp. 543–544