A5063784806- Cardiac Arrest and Resuscitation
- Diabetes and associated disorders
- Diet and metabolism studies
- Sepsis Diagnosis and Treatment
- Renal function and acid-base balance
- Congenital Heart Disease Studies
- Electrolyte and hormonal disorders
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Cytomegalovirus and herpesvirus research
- Health, Nursing, Elderly Care
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Ischemia and Reperfusion
- Appendicitis Diagnosis and Management
- Acute Kidney Injury Research
- Healthcare Policy and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neurological and metabolic disorders
- Palliative and Oncologic Care
- Immune Cell Function and Interaction
- Abdominal Surgery and Complications
- Nosocomial Infections in ICU
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2025
Universidade de São Paulo
2015-2024
Clinics Hospital of Ribeirão Preto
2009-2024
University of Calgary
2023
Universidade Brasil
2012-2022
Universidade de Ribeirão Preto
2003-2022
Cambridge University Press
2012
Universidade Federal de São Paulo
2009
University of Alberta
2007-2008
Hospital for Sick Children
2001-2007
Neutrophil extracellular traps (NETs) are innate defense mechanisms that also implicated in the pathogenesis of organ dysfunction. However, role NETs pediatric sepsis is unknown.Infant (2 weeks old) and adult (6 mice were submitted to by intraperitoneal (i.p.) injection bacteria suspension or lipopolysaccharide (LPS). infiltration, bacteremia, injury, concentrations cytokine, NETs, DNase plasma measured. Production reactive oxygen nitrogen species release neutrophils evaluated. To...
Apnea is a major complication of acute respiratory tract infection in young infants and may lead to the need for ventilatory support. Caffeine methylxanthine, which considered mainstay pharmacologic treatment apnea prematurity. On basis neonatal guidelines, caffeine has been used as stimulant infection-related apnea, despite low evidence its ability improve clinical outcomes. Hyperlactatemia reported adults with poisoning. Clarithromycin acts an inhibitor human cytochrome P450 impair drug...
The goal of this study was to examine the prevalence, assessment and management pediatric pain in a public teaching hospital. sample consisted 121 inpatients (70 infants, 36 children, 15 adolescents), their families, 40 physicians, 43 nurses. All participants were interviewed except infants children who could not communicate due clinical status. interview included open-ended questions concerning inpatients' symptoms during 24 h preceding data collection, as well...
To evaluate the usefulness of a spontaneous breathing trial for predicting extubation success in pediatric patients postoperative period after cardiac surgery compared with physician-led weaning.Randomized, controlled trial.PICU tertiary-care university hospital.A population following congenital heart disease.Patients on mechanical ventilation more than 12 hours who were considered ready weaning randomized to group or control group. The was performed continuous positive airway pressure...
To evaluate the effect of oral hygiene with 0.12% chlorhexidine gluconate on incidence nosocomial pneumonia and ventilator-associated (VAP) in children undergoing cardiac surgery.Prospective, randomized, double-blind, placebo-controlled trial.Pediatric intensive care unit (PICU) at a tertiary hospital.One hundred sixty surgery for congenital heart disease, randomized into 2 groups: (n = 87) control 73).Oral or placebo preoperatively twice day postoperatively until PICU discharge...
Objective: We aimed to investigate the epidemiology, risk factors, and short- medium-term outcome of acute kidney injury classified according pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease, Kidney Disease: Improving Global Outcomes criteria in critically ill children. Design: Prospective observational cohort study. Setting: Two eight-bed PICUs a tertiary-care university hospital. Patients: A heterogeneous population Interventions: None. Measurements Main Results: Demographic,...
Objective We aimed to assess the profile of respiratory viruses in young children hospitalized for acute lower tract infection (ALRI) and its association with disease severity, defined as need pediatric intensive care unit (PICU) admission. Design Prospective observational cohort study. Setting A tertiary-care university hospital Brazil. Patients Children younger than three years attending emergency room ALRI who were admitted hospital. Interventions None. Measurements main results...
The 2009 pandemic influenza A (H1N1) caused significant morbidity and mortality. Acute lung injury is the hallmark of disease, but multiple organ system dysfunction can develop lead to death. Therefore, we sought investigate whether there was postmortem evidence H1N1 presence virus-induced in autopsy specimens. Five cases which patients died virus infection were studied. lungs all showed macroscopic microscopic findings already described for (consolidation, edema, hemorrhage, alveolar...
To investigate whether perioperative serum levels of oxidative stress markers, thiobarbituric acid reactive substances (TBARS), and carbonyl moieties are associated with outcomes in children after heart surgery.Oxidative markers increased following surgery cardiopulmonary bypass (CPB) can play a role ischemia-reperfusion injury, but its associations myocardial dysfunction, low cardiac output syndrome (LCOS), not proven.In retrospective secondary analysis cohort study comprising 55 (median...
Objectives: We aimed to evaluate the value of serum cystatin C for detection acute kidney injury and pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease categories in critically ill children investigate whether was associated with outcome. Design: Prospective cohort study. Setting: PICU a tertiary-care university hospital. Patients: A heterogeneous population children. Interventions: None. Measurements Main Results: Blood 24-hour urine samples were collected daily over first 2...
We aimed to investigate the clinicopathological features of pertussis in children admitted a tertiary-care university hospital Brazil.This was retrospective cohort study all pediatric admissions with from January 1, 2008 December 31, 2014. also reported autopsy findings who died.Fifty-five patients over period had laboratorial confirmation Bordetella infection, 17 (30.9%) needed intensive care unit (PICU) admission and 6 (10.9%) died. All died were younger than 60 days old unvaccinated for...