A5014363434- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Renal function and acid-base balance
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Eicosanoids and Hypertension Pharmacology
- Infective Endocarditis Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Anesthesia and Neurotoxicity Research
- Cardiac tumors and thrombi
- Cardiac Arrhythmias and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Liver Disease and Transplantation
- Blood Pressure and Hypertension Studies
- Trauma Management and Diagnosis
- Atrial Fibrillation Management and Outcomes
Universidade de São Paulo
2016-2025
Weatherford College
2025
Universidade de Ribeirão Preto
2014-2024
Clinics Hospital of Ribeirão Preto
2004-2023
Fundação Faculdade de Medicina
1996-2023
Universidade Estadual de Campinas (UNICAMP)
2018-2022
Centrus Diagnósticos por Imagem
2020
Faculdade de Medicina de São José do Rio Preto
2018-2019
ORCID
2019
Seevic College
2018
The treatment of schizophrenia remains a challenge, and the currently available antipsychotic drugs are slow acting produce number adverse effects.To examine effectiveness safety single intravenous administration sodium nitroprusside (0.5 μg/kg/min for 4 hours) on positive, negative, anxiety, depressive symptoms in patients with schizophrenia.Single-center, randomized, double-blind, placebo-controlled trial performed from March 9, 2007, to 12, 2009.University teaching hospital São Paulo,...
Respiratory symptoms are one of COVID-19 manifestations, and the metalloproteinases (MMPs) have essential roles in lung physiology. We sought to characterize plasmatic levels matrix metalloproteinase-2 9 (MMP-2 MMP-9) patients with severe investigate an association between plasma MMP-2 MMP-9 clinical outcomes mortality. from treated ICU (COVID-19 group) Control were measured zymography. The study groups matched for age, sex, hypertension, diabetes, BMI, obesity profile. lower higher a group...
This controlled, prospective, nonrandomized clinical investigation has as its chief strength the fact that it was done in humans with active disease and apparently on fairly modest therapeutic regimens. The aim to present results of oxidative‐stress biomarkers suffering from pulmonary artery hypertension (PAH). Inflammation oxidative stress are essential PAH increased lipid peroxidation reduced antioxidant defenses. Twenty‐four adult patients both sexes, a mean age 21 years, were subdivided...
BACKGROUND When used to reverse the anticoagulant effect of heparin, protamine sulfate often causes vasodilation that can lead systemic hypotension. Protamine is rich in basic amino acid arginine, which precursor endothelial cell synthesis nitric oxide, and oxide active component endothelium-derived relaxing factor (EDRF). METHODS AND RESULTS To determine whether hypotensive could be due stimulated release EDRF, we studied rings (4-5 mm) canine coronary, femoral, renal artery suspended organ...
Summary Thromboangiitis obliterans (TAO) is a segmental inflammatory occlusive disorder that affects the arm and leg arteries of young smokers. The immune system seems to play critical role in aetiology TAO; however, knowledge aspects involved progression vascular tissue inflammation and, consequently, evolution this disease still limited. This study was carried out investigate cytokine levels tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-4, IL-17 IL-23 plasma TAO patients...
We investigated the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. The response to HCl-induced (7.4 6.5) was measured aortic rings pre-contracted with phenylephrine (Phe, 10− 6 M) or KCl (45 mM). vascular reactivity experiments were performed endothelium-intact and denuded rings, presence absence of indomethacin (10− 5 M), L-NAME 4 apamin glibenclamide M). effect acidosis (pH 7.0 on nitric oxide (NO) production evaluated isolated endothelial cells...
Aims It has been known for more than a century that pH changes can alter vascular tone. However, there is no consensus about the effects of on response. In this study, we investigated extracellular (pHo) intracellular (pHi) and nitric oxide concentration ([NO]i) in freshly isolated endothelial cells cross sections from rat aorta. Main Methods The HCl was used to reduce pHo 7.4 7.0 6.5; NaOH increase 8.0 8.5. fluorescent dyes 5-(and-6)-carboxy SNARF-1, acetoxymethyl ester, acetate (SNARF-1)...
Better treatments for schizophrenia are urgently needed. The therapeutic use of the nitric oxide (NO)-donor sodium nitroprusside (SNP) in patients with has shown promising results. role NO is still unclear, and modulation unexplored ketamine (KET) animal models to date. In present study, we compared behavioral effects pre- post-treatment SNP, glyceryl trinitrate (GTN), methylene blue (MB) acute KET model schizophrenia. study was designed test whether GTN, MB treatment taken after...
Penetrating cardiac injury, though infrequent, is associated with substantial mortality. In 2005, our research team conducted a comprehensive retrospective analysis of penetrating injuries managed at facility from 1990 to 2003. Now, two decades later, we the present study on attended in hospital over last 20 years. This medical records and trauma database data, focus survivors trauma, excluding those deceased upon arrival. Out 1,093 cases, 25 had an overall mortality rate 36%. Hemorrhage was...