Ultrathin metal-organic framework (MOF) nanosheets show great potential in various separation applications. In this study, MOF are incorporated as a gutter layer high-performance, flexible thin-film composite membranes (TFCMs) for CO2 separation. (∼3-4 nm) were prepared via surfactant-assisted method and subsequently coated onto porous support by vacuum filtration. This produced an ultrathin (∼25 nm), extremely flat layer, which serves highly permeable with reduced gas resistance when...

BACKGROUND Alternatives to room temperature storage of platelets (PLTs) may be beneficial extend the limited shelf life and support transfusion logistics in rural military areas. The aim this study was assess morphologic, metabolic, functional aspects PLTs stored at or refrigerated conditions cryopreserved. STUDY DESIGN AND METHODS A three‐arm pool‐and‐split carried out using buffy coat–derived 30% plasma/70% SSP+. three matched treatment arms were (20‐24°C), cold‐stored (2‐6°C),...

A novel tertiary amine catalyst and trithiocarbonate synergistic photo-induced controlled radical polymerization of methacrylates has been realized under mild UV irradiation, yielding polymethacrylates with low molecular weight distributions excellent end-group fidelity.

Abstract The use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via reversible addition‐fragmentation chain transfer (RAFT) process is reported for the first time. No pre‐treatment Hb or was required prior their as catalysts, indicating potential synthetic engineering in complex biological microenvironments without need ex vivo techniques. Owing naturally occurring prevalence reagents employed catalytic system (Hb and hydrogen peroxide), this...

Background Platelet ( PLT ) concentrates can be cryopreserved in dimethyl sulfoxide DMSO and stored at −80° C for 2 years. These storage conditions improve availability both rural military environments. Previous phenotypic vitro studies of PLTs are limited by comparison to fresh liquid‐stored , rather than over their clinically relevant shelf life. Further, nothing is known the effect reconstituting plasma a variety temperatures. Study Design Methods Apheresis were either room temperature 5...

Abstract The high toughness of natural spider-silk is attributed to their unique β-sheet secondary structures. However, the preparation mechanically strong rich materials remains a significant challenge due challenges involved in processing polymers/proteins, and managing assembly hydrophobic residues. Inspired by spider-silk, our approach effectively utilizes superior mechanical stability afforded localised domains within an amorphous network. Using grafting-from polymerisation hydrophilic...

Cyclodextrin-based supramolecular polyrotaxanes are for the first time used as soft nanoparticle additives selective layer of composite membranes. They exhibit outstanding gas transport characteristics at low additive percentages, due to dynamic nature PDMS side chains.

A reduced copper metal-organic framework (rCu-MOF) containing CuI ions was prepared by reducing raw MOFs (Cu-BTC). series of polymer functionalizations and coupling reactions could subsequently be achieved via CuAAC click chemistry, thus demonstrating the high activity, facile recyclability good structural stability rCu-MOFs for catalytic applications.

Herein, we report the synthesis of sliding-ring (SR) hydrogel networks in a one-pot click-mediated approach using α,ω-dialkyne poly(ethylene glycol) (PEG) and azido-functionalised cyclodextrin, which acts as both sliding cross-link end-capping agent. This novel resulted polymeric that possess combination SR covalent (CV) points. The extent inclusion complexation ratio to CV cross-links hydrogels was found be dependent on concentration precursors curing temperature. Based upon model studies...

BACKGROUND Alternatives to room temperature storage of platelets (PLTs) are interest support blood banking logistics. The aim this study was compare the presence biologic response modifiers (BRMs) in PLT concentrates stored under conventional conditions with refrigerated or cryopreserved PLTs. STUDY DESIGN AND METHODS A three‐arm pool‐and‐split carried out using buffy coat–derived PLTs 30% plasma/70% SSP+. three matched treatment arms were as follows: (20‐24°C), cold (2‐6°C), and (–80°C...

In natural silks, β ‐sheet crystals are embedded within an amorphous matrix resulting in polypeptide‐based nanocomposites. These contribute to the subsequent high strength and toughness of spider silk. Consequently, imitation mimicry such concepts utilizing polypeptides provide a pathway toward putatively achieving similar properties. Herein, introduction poly( l ‐valine) (PVal) nanocrystals into different fibers is investigated. Analysis micro‐ nanoscale features shows that polyvaline...

Background Platelet ( PLT ) concentrates frozen in dimethyl sulfoxide DMSO can be stored for extended periods at −80° C . s are a hyperconcentrated state to avoid postthaw washing and minimize residual Consequently, require reconstitution upon thawing. Although plasma, saline, additive solutions PAS s) have been used reconstitute s, comparison define an optimal solution recovery has not performed. Study Design Methods (5% final concentration) was added buffy coat–derived followed by...

Abstract This study presents the development of a novel solid state photocatalyst for photoinduced controlled radical polymerization methacrylates under mild UV irradiation (λ max ≈ 365 nm) in absence conventional photoinitiators, metal-catalysts or dye sensitizers. The design was based on our previous finding that organic amines can act synergistic photochemical reaction with thiocarbonylthio compounds to afford well polymethacrylates irradiation. Therefore, current contribution an...

BACKGROUND The storage of platelets (PLTs) in additive solution (AS) may facilitate improved PLT quality and possibly extension the shelf life. A minimum amount plasma is required when PLTs are stored AS, as a source glucose. aim this study was to assess effect reducing carryover 20% on SSP+ for an extended period. STUDY DESIGN AND METHODS Using pool‐and‐split design, buffy coat–derived were either 30% plasma/SSP+ or plasma/SSP+. In vitro analyses carried out Day 10. Metabolites markers...

The THERAFLEX UV-Platelets system uses shortwave ultraviolet C light (UVC, 254 nm) to inactivate pathogens in platelet components. Plasma carryover influences pathogen inactivation and quality following treatment. plasma the standard platelets produced by our institution are below intended specification (<30%).A pool split study was carried out comparing untreated UVC-treated with <30% (n = 10 pairs). This data compared components that met specifications (>30% plasma). were tested over...

Antifogging and frost-resistant coatings can be used in a wide range of applications enable high light transmission through substrates even under changes environmental conditions. In this study, surface confined cross-linked antifogging thin films are fabricated on glass slides via catalyst induced cross-linking (CIC), which has been recently introduced as an easy efficient methodology. Four different poly(ethylene glycol) (PEG)-based polymers with hydrophilicity synthesized to prepare CIC....

Abstract Background Refrigeration, or cold‐storage, of platelets may be beneficial to extend the limited shelf‐life conventionally stored and support transfusion protocols in rural military areas. The aim this study was compare morphologic, metabolic, functional aspects apheresis at room‐temperature (RT) cold conditions, either plasma supplemented with platelet additive solution (PAS). Study design methods Double‐dose were collected 100% 40% plasma/60% PAS‐E using Trima platform. One...

A nanostructured MOF composite was utilized as an enzyme mimic for the generation of hydroxyl radicals from hydrogen peroxide, which can subsequently initiate RAFT polymerizations in aqueous or organic media.

Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. This achieved via dual concept whereby noncovalent provided cyclodextrin host-guest interactions, and irreversible covalent mediated continuous assembly polymers (CAP). The cross-linked (DCPs) were efficiently infiltrated (∼80-93%) biomacromolecule dextran (molecular weight up to 500 kDa) provide high loadings (70-75%). Upon short exposure (5 s) UV light,...

Supramolecular polymers with monomers bound together by secondary interactions, such as polyrotaxanes (PRXs), consisting of alpha cyclodextrin (αCD) threaded onto poly(ethylene glycol) (PEG), have attracted interest a result their ability to overcome physical limitations present in conventional, covalently structured polymers. Herein, we describe the formation pH-responsive supramolecular assemblies from carboxyethylester bearing αCD and PEG PRXs. These PRXs were formed using Mw 20 kDa...

Abstract Background Cryopreservation of platelets with dimethylsulfoxide (DMSO) at −80°C increases their shelf life from days to years. Once thawed, are stored room temperature (RT), and the is limited 4‐6 hours. However, refrigeration (cold storage) may facilitate a prolongation thawed platelets. Study Design Methods ABO‐matched buffy coat–derived (30% plasma/70% SSP+) were cryopreserved in 5%‐6% DMSO. Paired platelet components resuspended 30% SSP+, then either 20°C‐24°C agitation (RT) or...

By precisely tuning the network architecture, tough, highly compressible hydrogels were engineered. The made by interconnecting high-functionality hydrophobic domains through linear tri-block chains, consisting of soft hydrophilic middle blocks, flanked with flexible blocks. In showing their applicability, efficient encapsulation and prolonged release drugs achieved.

Washing of red blood cells (RBC) can reduce unwanted biological response modifiers (BRMs) that mediate transfusion complications in infants. The aim this study was to examine the vitro quality and changes BRMs following washing paediatric RBC units.A pool split design used prepare (either 1 or 4 days old; n = 26 pairs). One unit washed with 0·9% saline by centrifugation then resuspended SAG-M, while other remained unwashed. Each divided produce four units paediatric-sized components. Samples...

Surface-confined ultra-thin polyrotaxane (PRX)-based films with tunable composition, surface topology and swelling characteristics were prepared by solid-state continuous assembly of polymers (ssCAP).