A5083480601- Hearing, Cochlea, Tinnitus, Genetics
- Bat Biology and Ecology Studies
- Neural dynamics and brain function
- Hearing Loss and Rehabilitation
- Animal Vocal Communication and Behavior
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Marine animal studies overview
- Noise Effects and Management
- Multisensory perception and integration
- Vestibular and auditory disorders
- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Visual perception and processing mechanisms
- Neural Networks and Applications
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Axon Guidance and Neuronal Signaling
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Neuroscience of respiration and sleep
- Animal Behavior and Reproduction
Northeast Ohio Medical University
2015-2025
Kent State University
2023
Ohio University
2006-2012
GTx (United States)
2012
University of Illinois Urbana-Champaign
1997-2006
Bogomoletz Institute of Physiology
1992-1997
National Academy of Sciences of Ukraine
1995-1997
Abstract Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age representing 26 identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately predicts chronological age. Across longevity is negatively the rate change at age-associated sites. Furthermore, analysis several bat genomes reveals...
The etiology of tinnitus is known to be diverse in the human population. An appropriate animal model should incorporate this pathological diversity. Previous studies evaluating effect acoustic over exposure (AOE) have found that animals typically display increased spontaneous firing rates and bursting activity auditory neurons, which often has been linked behavioral evidence tinnitus. However, only a subset directly associated these neural correlates individual animals. Furthermore vast...
The acoustic startle reflex (ASR) is a rapid, involuntary movement to sound, found in many species. ASR can be modulated by external stimuli and internal state, making it useful tool disciplines. data collection interpretation varies greatly across laboratories comparisons challenge.
Homeostatic plasticity, the ability of neurons to maintain their averaged activity constant around a set point value, is thought account for central hyperactivity after hearing loss. Here, we investigated putative role GABAergic neurotransmission in this mechanism noise-induced loss larger than 50 dB high frequencies guinea pigs. The effect inhibition linked normal functioning K + -Cl- co-transporter isoform 2 (KCC2) which maintains low intracellular concentration chloride. expression...
Several bat species live >20-40 years, suggesting that they possess efficient anti-aging and anti-cancer defenses. Here we investigate the requirements for malignant transformation in primary fibroblasts from four Myotis lucifugus, Eptesicus fuscus, Eonycteris spelaea, Artibeus jamaicensis - spanning evolutionary tree including longest-lived genera. We show do not undergo replicative senescence, express active telomerase, attenuated SIPs with dampened secretory phenotype. Unexpectedly,...
The central nucleus of the inferior colliculus (IC) is a major integrative center in auditory system. It receives information from both ascending and descending pathways. To determine how single IC neurons integrate over wide range sound frequencies levels, we examined their intracellular responses to frequency-modulated (FM) sounds awake little brown bats (Myotis lucifugus). Postsynaptic potentials were recorded response downward FM sweeps typical for (80-20 kHz) three subcomponents (80-60,...
Listeners with hearing loss have difficulty processing sounds in noisy environments. This is most noticeable for speech perception, but reflected a basic auditory task: detecting tonal signal noise background, i.e. simultaneous masking. It unresolved whether the mechanisms underlying masking arise from periphery or central system. Poor detection listeners sensorineural (SNHL) attributed to cochlear hair cell damage. However, alters neural Additionally, both psychophysical and...
Tinnitus is a maladaptive neuropathic condition that develops in humans and laboratory animals following auditory insult. In our previous study we demonstrated sound exposure leads to development of behavioral evidence tinnitus sample exposed mice. However, this mouse model did not account for long-term plasticity or aging, factors are commonly linked the human population. Therefore same group mice was monitored 360 days post exposure. assessed behaviorally by measuring gap-induced pre-pulse...
To study how sound intensity altered the temporal response pattern of a unit, we recorded from 92 single neurons in inferior colliculus (IC) little brown bat and investigated their firing patterns to brief tone pulses (2 msec duration) at characteristic frequency unit over wide dynamic range (10-90 dB pressure level). We found two unusual characteristics high levels approximately one-third IC investigated. For 16 (17%), an increase level not only elicited shorter latency spike count but also...
In vertebrate auditory systems, specialized combination-sensitive neurons analyze complex vocal signals by integrating information across multiple frequency bands. We studied interactions in of the inferior colliculus (IC) awake mustached bats, using intracellular somatic recording with sharp electrodes. Facilitated combinatorial are coincidence detectors, showing maximum facilitation when excitation from low- and high-frequency stimuli coincide. Previous work showed that facilitatory...
A number of central auditory neurons exhibit paradoxical latency shift (PLS), a response characterized by longer latencies at higher sound levels. PLS are known to play role in target ranging for echolocating bats that emit frequency-modulated sounds. We recently reported early inhibition unit's oscillatory discharges is critical the inferior colliculus (IC) little brown bats. The goal this study was determine and non-echolocating animals (frogs): 1) detailed characteristics whether...
Sounds in real-world situations seldom occur isolation. In spite of this, most studies the auditory system have employed sounds that serve to isolate physiological responses, namely, at low rates stimulation. It is unclear, however, whether basic response properties a neuron derived thereof, such as its amplitude and frequency selectivities, are applicable where rapid succession. present study, we investigated one neurons bat inferior colliculus (IC), i.e., rate-level function, tone pulses...