A5087329076- Advanced NMR Techniques and Applications
- X-ray Diffraction in Crystallography
- Force Microscopy Techniques and Applications
- Crystallization and Solubility Studies
- Carbon Nanotubes in Composites
- RNA modifications and cancer
- Clostridium difficile and Clostridium perfringens research
- Nuclear Physics and Applications
- Polydiacetylene-based materials and applications
- Medical Imaging and Pathology Studies
- RNA and protein synthesis mechanisms
- Various Chemistry Research Topics
- Chemical Synthesis and Characterization
- Mechanical and Optical Resonators
- Atomic and Subatomic Physics Research
- Radiopharmaceutical Chemistry and Applications
- Genomics and Phylogenetic Studies
- Aluminum toxicity and tolerance in plants and animals
- Nuclear Materials and Properties
- Surface Treatment and Coatings
- Advanced Polymer Synthesis and Characterization
- NMR spectroscopy and applications
- Nanopore and Nanochannel Transport Studies
- Nanotechnology research and applications
- Innovative Microfluidic and Catalytic Techniques Innovation
Stanford University
2015-2020
University of Alberta
2012-2016
Google (United States)
2015
Alberta Glycomics Centre
2012
University of Gdańsk
1988-1989
Forcing polymers to be semiconductors In mechanochemistry, the application of force a polymer is used pry open specific chemical bonds. Chen et al. leveraged this technique produce semiconducting blocks polyacetylene in an insulating precursor. Ring-opening metathesis polymerization tethered together series fused four-carbon rings, reminiscent unusual ladderane membrane lipids anaerobic ammonium-oxidizing bacteria. Subsequently, sonication unzipped these strained rings into alternating C=C...
We have previously reported a polymechanophore system, polyladderene, which underwent dramatic bond rearrangement in response to mechanical force yield semiconducting polyacetylene. Herein, we report the scalable synthesis of benzoladderenes as new mechanophore monomers. Ring-opening metathesis polymerization yielded homopolymers and block copolymers with controlled molecular weights low dispersity. The resulting nonconjugated poly(benzoladderene) was mechanochemically transformed into...
We have recently reported a polymechanophore system, polyladderene (PLDE), which dramatically transforms into polyacetylene (PA) upon mechanical stimulation. Herein, we optimized conditions to synthesize unprecedented block copolymers (BCPs) containing force-responsive by sequential ring-opening metathesis polymerization of different norbornenes and bromoladderene. Successful extension from PLDE other blocks required careful timing low temperatures preserve the reactivity PLDE-appended...
Gram-positive bacteria surround themselves with a multilayered macromolecular cell wall that is essential to survival and serves as major target for antibiotics. The of Staphylococcus aureus composed two structural components, peptidoglycan (PG) teichoic acid (WTA), together creating heterogeneous insoluble matrix poses challenge quantitative compositional analysis. Here, we present 13C cross polarization magic angle spinning solid-state nuclear magnetic resonance (NMR) spectra intact walls,...
Solid-state NMR is a powerful tool for quantifying chemical composition and structure in complex assemblies even whole cells. We employed N{P} REDOR to obtain atomic-level distance propensities intact 15N-labeled E. coli ribosomes. The experimental dephasing of shift-resolved lysyl amine nitrogens by phosphorus was comparable that expected from calculation N-P distances involving the lysines included crystal coordinates. Among nitrogen contributions spectra, strongest emerged dipolar...
Polymer mechanochemistry has traditionally been employed to study the effects of mechanical force on one or two chemical bonds within a polymer. It is underexploited for scalable synthesis wholly new materials by activating along entire polymer, especially products inaccessible other means. Herein we utilize polymer synthesize fluorinated polyacetylene, long-sought-after air-stable polyacetylene that eluded conventional Our synthetic approach proceeds via ultrasonication force-responsive...
After the production of 99mTc via 100Mo(p,2n)99mTc reaction, there is a requirement for separating from bulk 100Mo. Although number separation methods have been demonstrated, possibility using cartridge-based system particularly attractive routine use in good manufacturing practice (GMP) regulatory environment. This study confirmed that hydrophobic interaction chromatography (HIC) solid phase extraction (SPE) with PEG as stationary an efficient and easily automated method molybdate...
<p>Polymer mechanochemistry has traditionally been employed to study the effects of mechanical force on one or two chemical bonds within a polymer. It is underexploited for scalable synthesis wholly new materials by activating along entire polymer, especially products inaccessible other means. Herein we utilize polymer synthesize fluorinated polyacetylene, long-sought-after air-stable polyacetylene that eluded conventional Our synthetic approach proceeds via ultrasonication...