A5103739049- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Infective Endocarditis Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Acute Lymphoblastic Leukemia research
- Monoclonal and Polyclonal Antibodies Research
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Sarcoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- HER2/EGFR in Cancer Research
- Antimicrobial Resistance in Staphylococcus
- Aortic Disease and Treatment Approaches
- Neuroendocrine Tumor Research Advances
- Antibiotics Pharmacokinetics and Efficacy
- Cardiovascular Function and Risk Factors
- Hematopoietic Stem Cell Transplantation
- Ubiquitin and proteasome pathways
- Chemotherapy-induced organ toxicity mitigation
- Soft tissue tumor case studies
- Cardiac Imaging and Diagnostics
- Genomic variations and chromosomal abnormalities
Emory University
2016-2025
University School
2023
Michigan Medicine
2013-2022
University of Michigan
2014-2019
Roswell Park Comprehensive Cancer Center
2007-2017
St. Michael's Hospital
2013
University of Chicago Medical Center
2013
University at Buffalo, State University of New York
2003-2011
Buffalo State University
2003
Bristol-Myers Squibb (Germany)
1986-1989
Abstract BACKGROUND: There is a need to develop novel therapies for relapsed/refractory diffuse large B‐cell lymphoma (DLBCL) and identify biomarkers predictive therapeutic response. Lenalidomide was previously shown induce an overall response rate (ORR) of 28% in patients with DLBCL. It currently unknown if rates differ between different DLBCL subtypes. METHODS: The authors retrospectively evaluated clinical outcomes germinal center B‐cell–like versus nongerminal treated salvage...
Summary The immunomodulatory drugs (IMiDs) lenalidomide and actimid (also known as CC‐4047) are thalidomide analogues which more potent than their parental compound. In combination with rituximab, we have previously demonstrated that IMiDs synergistic in vivo anti‐tumour activity preclinical studies a human lymphoma severe combined immunodeficiency mouse model. This report further explored the mechanisms by exert anti‐lymphoma effects. Following exposure of subcutaneous tumours murine models...
Summary Ofatumumab is a new monoclonal antibody (mAb) targeting novel membrane‐proximal epitope on CD20. To better define ofatumumab’s activity, we conducted pre‐clinical studies in rituximab‐sensitive cell lines (RSCL), rituximab‐resistant (RRCL), ofatumumab‐exposed (OECLs), primary lymphoma cells, and xenograft model. RRCL OECL were generated by repeated exposure of sensitive cells to escalating doses rituximab or ofatumumab ± human serum. Antibody‐dependent cellular cytotoxicity (ADCC)...
Transcatheter aortic valve replacement (TAVR) is an alternative to surgical (SAVR) for the treatment of stenosis in patients at intermediate, high, and extreme risk mortality from SAVR. We examined recent trends (AVR) Michigan.The Michigan Society Thoracic Cardiovascular Surgeons Quality Collaborative (MSTCVS-QC) database was used determine number SAVR TAVR cases performed January 2012 through June 2017. Patients were divided into low, groups based on STS predicted (PROM). MSTCVS-QC also...
Summary Bcl‐2 proteins represent a rheostat that controls cellular viability. Obatoclax, BH3‐mimetic, has been designed to specifically target and counteract anti‐apoptotic proteins. We evaluated the biological effects of obatoclax on anti‐tumour activity rituximab chemotherapy agents. Obatoclax induced cell death rituximab/chemotherapy‐sensitive (RSCL), ‐resistant lines (RRCL) primary tumour‐cells derived from patients with B‐cell lymphomas ( N = 39). also enhanced had synergistic when...
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E-cadherin (E-cad) and epidermal growth factor receptor (EGFR) are important cell adhesion signaling pathway mediators. This study aimed to assess their expression in lung adenocarcinoma (AdC) squamous carcinoma (SCC) association with clinicopathologic variables. In all, 130 resectable cancers (stages I–IIIA) were studied using a high-density tissue microarray. Two three cores from each case arrayed into blocks Beecher system. Immunohistochemistry was performed an avidin–biotin complex...
Abstract Myeloid sarcoma (MS) is a tumor mass of myeloblasts or immature myeloid cells occurring in an extramedullary site. In this study, seven cases MS [stomach (1), testis skin (2), and lymph node (3)] 3 synchronous 1 follow‐up bone marrow (BM) samples were studied for genomic abnormalities using array comparative hybridization (array‐CGH). Array‐CGH construction used ∼5,400 bacterial artificial chromosome clones from the RPCI‐11 library, spanning human genome. Data analyzed DNAcopy...
In an attempt to define mechanisms by which B-cell non-Hodgkin lymphoma (NHL) may escape rituximab immunotherapy, we developed several rituximab-resistant cell lines (RRCL) generated from the rituximab-sensitive (RSCL) Raji and RL. Rituximab resistance was associated with CD20 downregulation upregulation of CD52 complement inhibitory proteins (CIPs) CD55 CD59. No significant alemtuzumab-associated complement-mediated lysis (CMC) or antibody-dependent cellular cytotoxicity (ADCC) demonstrated...
Background— Prior cardiac surgery (PCS) can complicate the presentation and management of patients with type A acute aortic dissection (TAAAD). This report from International Registry Acute Aortic Dissection examines this hypothesis. Methods Results— total 352 2196 TAAAD (16%) enrolled in had before dissection, including coronary artery bypass grafting (34%), or mitral valve (36%), (42%), other (16%). Those PCS were older, a higher frequency diabetes mellitus, hypertension, atherosclerosis,...
We describe 15 patients (9 children) with precursor B-cell (pB) acute lymphoblastic leukemia (ALL) surface immunoglobulin (sIg) light chain restriction revealed by flow cytometric immunophenotyping (FCI). The same sIg+ immunophenotype was present at diagnosis and in 3 relapses 1 patient. In patients, blasts were CD19+CD10+ (bright coexpression) 14, CD34+ 12, κ+ λ+ 3; 8 of 8, terminal deoxyribonucleotidyl transferase (TdT)+; 4, IgD+ 2 IgM+ 1. CD34– cases included TdT+ case, t(1;19)(q23;p13),...