A5045318336- Trace Elements in Health
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Iron Metabolism and Disorders
- Metal complexes synthesis and properties
- RNA and protein synthesis mechanisms
University of Saskatchewan
2020-2024
Mediator of ERBB2-driven cell motility 1 (MEMO1) is an evolutionary conserved protein implicated in many biological processes; however, its primary molecular function remains unknown. Importantly, MEMO1 overexpressed types cancer and was shown to modulate breast metastasis through altered motility. To better understand the cells, we analyzed genetic interactions using gene essentiality data from 1028 lines found multiple iron-related genes exhibiting relationships with MEMO1. We...
Abstract Mediator of ERBB2-driven Cell Motility 1 (MEMO1) is an evolutionary conserved protein implicated in many biological processes; however, its primary molecular function remains unknown. Importantly, MEMO1 overexpressed types cancer and was shown to modulate breast metastasis through altered cell motility. To better understand the cells, we analyzed genetic interactions using gene essentiality data from 1028 lines found multiple iron-related genes exhibiting relationships with MEMO1....
MEMO1 is an evolutionary conserved protein implicated in many biological processes, however its primary molecular function remains unknown. Importantly, overexpressed breast cancer and modulates metastasis through altered cell motility. has been reported to be a copper-dependent redox-active protein, but metal-binding properties have not investigated. To understand the functional role of MEMO1, we analyzed genetic interactions using DepMap gene essentiality data found multiple iron-related...
Abstract Nanobodies are genetically engineered single domain antibodies derived from the unusual heavy-chain only found in llamas and camels. The small size of nanobodies flexible selection schemes make them uniquely versatile tools for protein biochemistry cell biology. We have developed a panel against metal binding domains human copper transporter ATP7B, multidomain membrane with complex regulation enzymatic activity intracellular localization. To enable use as to investigate transport...