A5089668148- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Neurogenesis and neuroplasticity mechanisms
- IL-33, ST2, and ILC Pathways
- Neurological Disease Mechanisms and Treatments
- Inflammation biomarkers and pathways
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Alzheimer's disease research and treatments
- Hydrogen's biological and therapeutic effects
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
Izmir University
2019-2024
Dokuz Eylül University
2019-2024
Among neonates, hypoxic-ischemic encephalopathy is the most significant cause of mortality and hypoxia-ischemia among leading causes brain damage. The microglia are primary mediators neuroinflammation. NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation first line defense in central nervous system. Numerous studies have shown that NLRP3 activated pro-inflammatory cytokines upregulated upon hypoxia-ischemia-induced However, aberrant results cell death tissue...
Reactive oxygen species (ROS) are generated within the cell and serve as second messengers in fundamental cellular processes under physiologic conditions. Although deleterious effects of high-level ROS associated with oxidative stress well established, it is unclear how developing brain reacts to redox changes. Our aim investigate alteration affects neurogenesis mechanism that underlies it.We investigated vivo microglial polarization zebrafish after hydrogen peroxide (H2O2) incubation. To...