A5047484413- Inflammasome and immune disorders
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Nuclear Structure and Function
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- Alzheimer's disease research and treatments
- Genomics, phytochemicals, and oxidative stress
- Circadian rhythm and melatonin
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Inflammation biomarkers and pathways
- Planarian Biology and Electrostimulation
- Signaling Pathways in Disease
- RNA modifications and cancer
- Cardiac tumors and thrombi
- Tissue Engineering and Regenerative Medicine
- Ferroptosis and cancer prognosis
- Curcumin's Biomedical Applications
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
Dokuz Eylül University
2019-2024
The University of Texas Health Science Center at Houston
2022-2023
Izmir University
2019-2022
University of North Carolina at Chapel Hill
2018-2021
Izmir Institute of Technology
2014-2021
Ege University
2011
Inflammation is a crucial component of various stress-induced responses that contributes to the pathogenesis major depressive disorder (MDD). Depressive-like behavior (DLB) characterized by decreased mobility and occurs in systemic infection induced Lipopolysaccharide (LPS) experimental animals considered as model exacerbation MDD. We assessed effects melatonin on behavioral changes inflammatory cytokine expression hippocampus mice LPS-induced DLB, well its NLR Family Pyrin Domain Containing...
Introduction: Mutations in the LMNA gene, encoding Lamin A/C (LMNA), are established causes of dilated cardiomyopathy (DCM). The phenotype is typically characterized by progressive cardiac conduction defects, arrhythmias, heart failure, and premature death. DCM primarily considered a disease myocytes. However, also expressed other cell types, including fibroblasts. Aim: purpose study was to determine contribution fibroblasts caused deficiency. Methods Results: Lmna gene deleted crossing...
Arrhythmogenic cardiomyopathy (ACM) is hereditary caused by pathogenic variants (mutations) in genes encoding the intercalated disc (ID), particularly desmosome proteins. ACM mutations DSP gene desmoplakin (DSP) characterized prominence of cell death, myocardial fibrosis, and inflammation, referred to as cardiomyopathy.The aim this article was gain insight into pathogenesis Dsp exclusively deleted cardiac myocytes using tamoxifen-inducible MerCreMer (Myh6-McmTam) floxed (DspF/F) mice...
The Cre-LoxP technology, including the tamoxifen (TAM) inducible MerCreMer (MCM), is increasingly used to delineate gene function, understand disease mechanisms, and test therapeutic interventions. We set determine effects of TAM-MCM on cardiac myocyte transcriptome. Expression MCM was induced specifically in myocytes upon injection TAM myosin heavy chain 6-MCM (Myh6-Mcm) mice for 5 consecutive days. Cardiac myocardial histology, expression (RNA-sequencing) were analyzed 2 weeks after...
Mechanical loads can regulate cell proliferation and differentiation at various stages of development homeostasis. However, the extension this regulatory effect mechanical on cancer cells is largely unknown. Increased physical compliance one key features cells, which may hamper transmission to these within tumor microenvironment. Here we tested whether brief daily application an external low magnitude stimulus (LMMS), would impede growth MDA-MB-231 aggressive type breast in vitro for 3 wks...
Mesenchymal stem cells (MSCs) maintain the musculoskeletal system by differentiating into multiple lineages, including osteoblasts and adipocytes. Mechanical signals, strain low-intensity vibration (LIV), are important regulators of MSC differentiation via control exerted through cell structure. Lamin A/C is a protein vital to nuclear architecture that supports chromatin organization contributes mechanical integrity nucleus. We investigated whether lamin mechanoresponsiveness functionally...
Mutations in the DSP gene encoding desmoplakin, a constituent of desmosomes at intercalated discs (IDs), cause phenotype that spans arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy. It is typically characterized by biventricular enlargement dysfunction, myocardial fibrosis, cell death, arrhythmias. The canonical wingless-related integration (cWNT)/β-catenin pathway implicated pathogenesis ACM. β-catenin an indispensable co-transcriptional regulator cWNT member IDs. We...
Ethyl pyruvate is a molecule with anti-inflammatory and pro-metabolic effects. has been shown to ameliorate the clinical pathological findings of neurodegenerative diseases such as Alzheimer’s Parkinson’s Diseases in rodents. Its neuroprotective effects are widely investigated animal cellular models. Our study aimed investigate mechanism impact on NLRP3 inflammasome activation N9 microglial cell line. results indicated that ethyl significantly suppressed LPS ATP-induced activation, decreased...
Aging is associated with cardiac myocyte loss, sarcopenia, and dysfunction. Adult myocytes are postmitotic cells an insufficient proliferative capacity to compensate for loss. The canonical WNT (cWNT) pathway involved in the regulation of cell cycle reentry various types. effects cWNT on expression genes unknown.The aim study was identify whose regulated by β-catenin, indispensable component signaling, myocytes.Cardiac myocyte-specific tamoxifen-inducible MerCreMer (Myh6-Mcm) mice were used...
Physical exercise is beneficial for bone tissue health, yet its usage limited preventing osteoporosis. Even though natural the from development to homeostasis, mechanical loads present with a multitude of physical parameters, including amplitude, duration, frequency, and distribution. Utilizing most parameters may potentiate nonpharmaceutical tool biotechnology prevent treat loss related aging, bedrest, sedentary lifestyles, weightlessness, other diseases. Low intensity vibrations (LIVs)...
ABSTRACT Aim Mutations in the DSP gene encoding desmoplakin, a constituent of desmosomes at intercalated discs (IDs), cause phenotype that spans arrhythmogenic cardiomyopathy (ACM) and dilated (DCM). It is typically characterized by biventricular enlargement dysfunction, severe myocardial fibrosis, cell death, arrhythmias. The canonical WNT (cWNT)/β-catenin signaling pathway implicated pathogenesis ACM. Given β-catenin, an indispensable co-transcriptional regulator cWNT pathway, also member...
Abstract Mesenchymal stem cells (MSC) maintain the musculoskeletal system by differentiating into multiple cell types including osteocytes and adipocytes. Mechanical signals, strain low intensity vibration (LIV), are important regulators of MSC differentiation. Lamin A/C is a vital protein for nuclear architecture that supports chromatin organization, as well mechanical integrity mechano-sensitivity nucleus in MSCs. Here, we investigated whether mechano-responsiveness functionally coupled...
As the world population ages, need for alternative therapies neurodegenerative diseases is increasing. Neuronal tissue engineering one of most promising methods creating in vitro disease models and as well regeneration lost brain due to diseases. But inherent difficulties culturing neurons glia vitro, studies this field proceeds slowly. Our aim produce surfaces that nerve cells can attach grow on vitro. Electrospun chitosan fibers are shown be suitable were produced three different chemical...