A5072110723- Inflammasome and immune disorders
- Circadian rhythm and melatonin
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Genetic Mapping and Diversity in Plants and Animals
- Plant Reproductive Biology
- Ubiquitin and proteasome pathways
- IL-33, ST2, and ILC Pathways
- Peptidase Inhibition and Analysis
- Genomics, phytochemicals, and oxidative stress
- Biotin and Related Studies
- S100 Proteins and Annexins
- Cerebrovascular and Carotid Artery Diseases
- Coenzyme Q10 studies and effects
- Prostate Cancer Treatment and Research
- Plant and animal studies
- Parkinson's Disease Mechanisms and Treatments
- Synthesis and Biological Evaluation
- Genetic diversity and population structure
- Advanced Proteomics Techniques and Applications
- Stress Responses and Cortisol
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Redox biology and oxidative stress
- Melanoma and MAPK Pathways
Izmir University
2019-2024
Bursa Uludağ Üni̇versi̇tesi̇
2024
Dokuz Eylül University
2021-2024
Lusaka Apex Medical University
2023
Max Planck Institute for Developmental Biology
2017-2018
Inflammation is a crucial component of various stress-induced responses that contributes to the pathogenesis major depressive disorder (MDD). Depressive-like behavior (DLB) characterized by decreased mobility and occurs in systemic infection induced Lipopolysaccharide (LPS) experimental animals considered as model exacerbation MDD. We assessed effects melatonin on behavioral changes inflammatory cytokine expression hippocampus mice LPS-induced DLB, well its NLR Family Pyrin Domain Containing...
NLRP3 inflammasome activation contributes to several pathogenic conditions, including lipopolysaccharide (LPS)-induced sickness behavior characterized by reduced mobility and depressive behaviors. Dimethyl fumarate (DMF) is an immunomodulatory anti-oxidative molecule commonly used for the symptomatic treatment of multiple sclerosis psoriasis. In this study, we investigated potential use DMF against microglial both in vitro vivo. For studies, LPS- ATP-stimulated N9 cells were induce...
The equal probability of transmission alleles from either parent during sexual reproduction is a central tenet genetics and evolutionary biology. Yet, there are many cases where this rule violated. preferential or genotypes termed ratio distortion (TRD). Examples TRD have been identified in species, implying that they universal, but the resolution species-wide studies limited. We performed screen for over 500 segregating F2 populations Arabidopsis thaliana using pooled reduced-representation...
Abstract Neurodegenerative diseases impact the structure and operation of nervous system, causing progressive irreparable harm. Efforts for distinguishing neurodegenerative in their early stages are continuing. Despite several biomarkers being identified, there is always search more accurate abundant ones. Additionally, it can be difficult to pinpoint precise disorder affecting a patient as symptoms these conditions frequently overlap. Numerous studies have shown that pathological changes...
Abstract The equal probability of transmission alleles from either parent during sexual reproduction is a central tenet genetics and evolutionary biology. Yet, there are many cases where this rule violated. Such violations limit intraspecific gene flow can facilitate the formation genetic barriers, first step in speciation. Biased alleles, or segregation distortion, result number biological processes including epistatic interactions between incompatible loci, gametic selection, meiotic...
Objective: This study aimed to investigate the biomarker potential of exosomes as autophagic regulators for discriminating ulcerated from smooth ones by serum-derived exosome isolation and real-time quantitative polymerase chain reaction (RT-qPCR) analysis. Methods: Eight carotid artery stenosis (CAS) patients (6 males, 2 females; mean age: 65.7±11 years) were included in conducted. Plaque ulceration was determined Doppler ultrasonography. Afterward, serum separated exosome/exosomal RNA...
Neurodegenerative diseases impact the structure and operation of nervous system, causing progressive irreparable harm. The absence distinguishable symptoms in early stages neurodegenerative makes diagnosis challenging. Additionally, it can be difficult to pinpoint precise disorder affecting a patient as these conditions frequently overlap. Numerous studies have shown that pathological changes occur years before clinical signs appear. Therefore, is crucial discover blood-based biomarkers for...