A5066031376- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- IL-33, ST2, and ILC Pathways
- Tryptophan and brain disorders
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Autoimmune and Inflammatory Disorders Research
- Circular RNAs in diseases
- Circadian rhythm and melatonin
- Advanced Glycation End Products research
- Curcumin's Biomedical Applications
- Ocular Diseases and Behçet’s Syndrome
- Immune Response and Inflammation
- Inflammation biomarkers and pathways
- Glutathione Transferases and Polymorphisms
- Stress Responses and Cortisol
- Synthesis and Biological Evaluation
- Medicinal Plants and Bioactive Compounds
University of Luxembourg
2024
Izmir University
2019-2022
Dokuz Eylül University
2018-2022
Military Medical Academy
2005
Inflammation is a crucial component of various stress-induced responses that contributes to the pathogenesis major depressive disorder (MDD). Depressive-like behavior (DLB) characterized by decreased mobility and occurs in systemic infection induced Lipopolysaccharide (LPS) experimental animals considered as model exacerbation MDD. We assessed effects melatonin on behavioral changes inflammatory cytokine expression hippocampus mice LPS-induced DLB, well its NLR Family Pyrin Domain Containing...
NLRP3 inflammasome activation contributes to several pathogenic conditions, including lipopolysaccharide (LPS)-induced sickness behavior characterized by reduced mobility and depressive behaviors. Dimethyl fumarate (DMF) is an immunomodulatory anti-oxidative molecule commonly used for the symptomatic treatment of multiple sclerosis psoriasis. In this study, we investigated potential use DMF against microglial both in vitro vivo. For studies, LPS- ATP-stimulated N9 cells were induce...
Sulforaphane (SFN) is a natural product with cytoprotective, anti-inflammatory and antioxidant effects. In this study, we evaluated the mechanisms of its effects on lipopolysaccharide (LPS)-induced cell death, inflammation, oxidative stress, polarization in murine microglia. We found that SFN protects N9 microglial cells upon LPS induced death suppress LPS- levels secreted pro-inflammatory cytokines, Tumor necrosis factor-alpha (TNF-α), Interleukin-1 beta (IL-1β) Interleukin-6 (IL-6). also...
Objective: Behçet's disease (BD) is a rare, chronic, multisystem inflammatory disorder. The prevalence of BD higher in the Middle Eastern and Mediterranean populations. Another chronic disease, familial fever (FMF), also known to be highly prevalent these FMF patient population than populations rich . Both have some pathophysiological features common they result from inappropriate activation neutrophils. Clinical manifestations both diseases can mimic each other coexistence same has been...
Ethyl pyruvate is a molecule with anti-inflammatory and pro-metabolic effects. has been shown to ameliorate the clinical pathological findings of neurodegenerative diseases such as Alzheimer’s Parkinson’s Diseases in rodents. Its neuroprotective effects are widely investigated animal cellular models. Our study aimed investigate mechanism impact on NLRP3 inflammasome activation N9 microglial cell line. results indicated that ethyl significantly suppressed LPS ATP-induced activation, decreased...