A5010210472- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
Dokuz Eylül University
2021
Ethyl pyruvate is a molecule with anti-inflammatory and pro-metabolic effects. has been shown to ameliorate the clinical pathological findings of neurodegenerative diseases such as Alzheimer’s Parkinson’s Diseases in rodents. Its neuroprotective effects are widely investigated animal cellular models. Our study aimed investigate mechanism impact on NLRP3 inflammasome activation N9 microglial cell line. results indicated that ethyl significantly suppressed LPS ATP-induced activation, decreased...
Cancer is one of the most important causes death in our era.Multifactorial are involved formation cancer.The reduction apoptosis these reasons.Failure to activate pathways can lead resistance current treatment approaches cancers.A better understanding molecular events that regulate cancers and cancer therapy form basis a more rational approach development targeted therapies fight against cancer.