A5033836407- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Immune Response and Inflammation
- Elasticity and Material Modeling
- Renal Transplantation Outcomes and Treatments
- Anatomy and Medical Technology
- Organ Donation and Transplantation
- Clinical Nutrition and Gastroenterology
- Prostate Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Hepatitis C virus research
- Bone health and osteoporosis research
- COVID-19 diagnosis using AI
- Complement system in diseases
- Radiomics and Machine Learning in Medical Imaging
- Data-Driven Disease Surveillance
- Automotive and Human Injury Biomechanics
- Erythropoietin and Anemia Treatment
- Biomedical and Engineering Education
- Cellular and Composite Structures
- Ultrasound in Clinical Applications
- Surgical Simulation and Training
- Connective tissue disorders research
University College London
2019-2024
Sapienza University of Rome
2012-2024
The Royal Free Hospital
2019-2024
Charité - Universitätsmedizin Berlin
2021
•We hypothesised that a TLR4 inhibitor, TAK-242, might mitigate the negative effects of G-CSF in ACLF.•G-CSF alone increases mortality and promotes inflammation rodent models ACLF.•The combination TAK-242 inhibits inflammation, hepatic regeneration prevents ACLF. Background & AimsAcute-on-chronic liver failure (ACLF) is characterised by high short-term mortality, systemic regeneration. Its treatment major unmet medical need. This study was conducted to explore whether combining Toll-like...
Abstract The lipopolysaccharide (LPS)– toll-like receptor-4 (TLR4) pathway plays an important role in liver failure. Recombinant alkaline phosphatase (recAP) deactivates LPS. aim of this study was to determine whether recAP prevents the progression acute and acute-on-chronic failure (ACLF). Eight groups rats were studied 4-weeks after sham surgery or bile duct ligation injected with saline LPS mimic ACLF. Acute induced Galactosamine-LPS both models animals treated prior administration. In...
Objective Coronavirus disease 2019 demonstrated the inconsistencies in adequately responding to biological threats on a global scale due lack of powerful tools for assessing various factors formation epidemic situation and its forecasting. Decision support systems have role overcoming challenges health monitoring light current or future outbreaks. This paper focuses some applied examples logistic planning, key service Earth Cognitive System Disease project, here presented, evidencing added...
Abstract The aim of this study was to evaluate the improvement prognostic parameters after treatment with molecular adsorbent recirculating system (MARS) in patients fulminant hepatitis (FH). conducive a positive prognosis include: Glasgow Coma Scale (GCS) score ≥11, intracranial pressure (ICP) <15 mm Hg or an systolic peak flow 25–32 cm/s via Doppler ultrasound middle cerebral artery, lactate level <3 mmol/L, tumor necrosis factor‐α <20 pg/mL, interleukin (IL)‐6 <30 and change...
In recent years, three-dimensional reconstruction (3DR) models have become a standard tool in several medical fields such as education, surgical training simulation, patient-doctor communication, and planning. Postoncologic reconstructive surgery thoracic diseases might benefit from 3DR models; however, limited data on this application been published worldwide. paper, the aim was to report our experience with modeling determine resection plan patient desmoid tumor of chest wall. For better...
The assessment of spatio-temporal distribution water within the cancellous bone structure remains a challenging issue. In present study, 3D finite element model trabecular region with pore morphology reconstructed from micro-CT scans is developed aim evaluating dynamics diffusion through tissue. proposed formulates perspective particles motion. Newton’s second law adapted to consider Brownian motion used describe particle in Lagrangian framework. outcomes allow investigate temporal evolution...