A5025136952- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Malaria Research and Control
- Mosquito-borne diseases and control
- Public Health and Nutrition
- Advanced Biosensing Techniques and Applications
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Antifungal resistance and susceptibility
- COVID-19 Impact on Reproduction
- COVID-19 epidemiological studies
- Cancer survivorship and care
- HIV Research and Treatment
- COVID-19 Prevention and Impact
- Parasitic Diseases Research and Treatment
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Fungal Infections and Studies
- Virology and Viral Diseases
Kanazawa University
2021-2025
University of Indonesia
2024-2025
Hasanuddin University
2024
Evaluating long-term immunity after COVID-19 infection and vaccination is critical for managing potential outbreaks. The aim of this study was to develop a cost-effective in-house enzyme-linked immunosorbent assay (ELISA) based on Escherichia coli-expressed SARS-CoV-2 spike protein (E-S1) antibody detection evaluate its performance. system validated by comparing the ELISA results with those obtained using commercial HEK293-expressed (H-S1). Recombinant produced in E. coli, purified,...
Evaluating long-term immunity after COVID-19 infection and vaccination is critical for managing potential outbreaks. The aim of this study was to develop a cost-effective in-house enzyme-linked immunosorbent assay (ELISA) based on Escherichia coli-expressed SARS-CoV-2 spike protein (E-S1) antibody detection evaluate its performance. system validated by comparing the ELISA results with those obtained using commercial HEK293-expressed (H-S1). Recombinant produced in E. coli, purified,...
Background: A significant complication among post-tuberculosis patients is chronic pulmonary aspergillosis (CPA), with prevalence and outcomes varying by region. This study aimed to explore the epidemiology, clinical characteristics, microbiological profiles of 219 persistent respiratory symptoms lung cavities in Indonesia. Methods: The were divided into CPA (n = 144) non-CPA 75) groups. cross-sectional diagnosed using ERS/ESCMID criteria, integrating clinical, radiological, fungal...
Viral vectors are a potent vaccine platform for inducing humoral and T-cell immune responses. Among the various viral vectors, replication-competent ones less commonly used coronavirus disease 2019 (COVID-19) development compared with replication-deficient ones. Here, we show availability of smallpox LC16m8Δ (m8Δ) as vector COVID-19 vaccine. M8Δ is genetically stable variant licensed highly effective Japanese LC16m8. generated two m8Δ recombinants: one harbouring gene cassette encoding...
To fight the COVID-19 pandemic, immunity against SARS-CoV-2 should be achieved not only through natural infection but also by vaccination. The effect of vaccination on previously infected persons is debatable.A prospective cohort was undergone to collect sera from unvaccinated survivors and vaccinated persons-with without pre-infection. were analyzed for anti-receptor binding domain (RBD) titers ELISA capacity neutralize pseudovirus Wuhan-Hu-1 strain luciferase assays.Neither antibody nor...
Among Plasmodium spp. responsible for human malaria, vivax ranks as the second most prevalent and has widest geographical range; however, vaccine development lagged behind that of falciparum, deadliest species. Recently, we developed a multistage P. falciparum based on heterologous prime-boost immunization regimen utilizing attenuated vaccinia virus strain LC16m8Δ (m8Δ)-prime adeno-associated type 1 (AAV1)-boost, demonstrated 100% protection more than 95% transmission-blocking (TB) activity...
In the post-pandemic era, evaluating long-term immunity against COVID-19 has become increasingly critical, particularly in light of continuous SARS-CoV-2 mutations. This study aimed to assess immunogenicity by analyzing booster shots’ impact and sera infection history collected Makassar, Indonesia. We measured anti-RBD IgG levels neutralization capacity (NC) both wild-type (WT) Wuhan-Hu Omicron XBB 1.5 variants across groups vaccinated individuals with no (NB), single (SB), double (DB). The...
(1) Background: To fight for COVID-19 pandemic, immunity against SARS-CoV-2 should be achieved not only through natural infection but also vaccination. Controversies exist about the effect of vaccination on previously infected persons; (2) Methods: A prospective cohort was undergone to collect sera from unvaccinated survivors and vaccinated persons--with without pre-infection. The were analyzed anti-Receptor Binding Domain (RBD) titers by ELISA capacity neutralize pseudovirus Wuhan-Hu-1...
(1) Background: To fight for COVID-19 pandemic, immunity against SARS-CoV-2 should be achieved not only through natural infection but also vaccination. Controversies exist about the effect of vaccination on previously infected persons; (2) Methods: A prospective cohort was undergone to collect sera from unvaccinated survivors and vaccinated persons--with without pre-infection. The were analysed anti-Receptor Binding Domain (RBD) titers by ELISA capacity neutralize pseudovirus Wuhan-Hu-1...
The Malaria Vaccine Technology Roadmap 2013 (World Health Organization) aims to develop safe and effective vaccines by 2030 that will offer at least 75% protective efficacy against clinical malaria reduce parasite transmission. Here, we demonstrate a highly multistage vaccine both the pre-erythrocytic sexual stages of Plasmodium falciparum protects reduces transmission in murine model. is based on viral-vectored platform, comprising highly-attenuated vaccinia virus strain, LC16m8Δ (m8Δ),...
In the post-pandemic era, evaluating long-term immunity against COVID-19 has become increasingly critical, particularly in light of continuous SARS-CoV-2 mutations. This study aimed to assess humoral immune response sera collected Makassar. We measured anti-RBD IgG levels and neutralization capacity (NC) both Wild-Type (WT) Wuhan-Hu Omicron XBB.1.5 variants across groups COVID-19-vaccinated individuals with no booster (NB), single (SB), double (DB). The mean durations since last vaccination...
: We developed a multistage
Abstract. The neutrophil lymphocyte ratio (NLR) is one of the variables related to severity COVID-19 disease. Therefore, we evaluated value NLR in patients and its relation symptoms at Tadjuddin Chalid Hospital, Makassar. We recruited visiting Hospital Makassar who were willing take part study April August 2021. Demographic, clinical laboratory data recorded through interviews medical records. disease classified according guidelines from association Indonesian pulmonary doctors, internal...
Introduction: Depression affects 45.19% of pulmonary tuberculosis (TB) patients' adherence to treatment, resulting in increased morbidity and death, medication resistance, continued disease transmission. This study aimed examine the relationship between omega-6/omega-3 (ꞷ-6/ꞷ-3) polyunsaturated fatty acids (PUFA) intake ratio depression score patients with TB at Persahabatan National Respiratory Referral Hospital, Jakarta. Methods: was a cross-sectional 99 subjects TB. Data were collected...