A5035317520- Malaria Research and Control
- Mosquito-borne diseases and control
- Insect Pest Control Strategies
- Computational Drug Discovery Methods
- Parasites and Host Interactions
- Digital Imaging for Blood Diseases
- Image Processing Techniques and Applications
- Insect Resistance and Genetics
- Diverse Scientific Research Studies
- Parasitic Infections and Diagnostics
- Dengue and Mosquito Control Research
- Vector-borne infectious diseases
- vaccines and immunoinformatics approaches
- Medicinal Plant Research
- Primate Behavior and Ecology
- Hemoglobinopathies and Related Disorders
- Drug Transport and Resistance Mechanisms
- Advanced Biosensing Techniques and Applications
- Travel-related health issues
- HIV/AIDS drug development and treatment
- Parasitic infections in humans and animals
- Drug-Induced Hepatotoxicity and Protection
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Cell Image Analysis Techniques
Eijkman Institute for Molecular Biology
2016-2025
National Research and Innovation Agency
2022-2025
National Nuclear Energy Agency of Indonesia
2023
Hasanuddin University
2005-2019
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2019
Kenya Medical Research Institute
2016
National Institute of Allergy and Infectious Diseases
2016
National Institutes of Health
2016
Montana State University
2016
Triangle
2016
A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure 1,341 children aged ≥ 6 months ≤ 5 years 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed release vaporized chemical). Monthly blood screening and biweekly human-landing mosquito catches performed during 10-month baseline (June...
Background Asymptomatic Plasmodium spp. infections and anemia are highly prevalent conditions in tropical regions. We studied whether asymptomatic parasitemia induces hepcidin- and/or cytokine-mediated iron maldistribution anemia.Design Methods A group of 1197 Indonesian schoolchildren, aged 5–15 years, were screened by microscopy for the presence parasitemia. Concentrations hemoglobin, serum hepcidin parameters status inflammation determined at baseline 4 weeks after antimalarial...
A randomized, double-blinded, placebo-controlled study was conducted to examine the effect of spatial repellent (SR) in households at risk malaria Indonesia. Following presumptive radical cure for 180 adult men representing sentinels new infection four clusters within two villages, all were given either metofluthrin or placebo mosquito coils. Weekly blood smear screening and human-landing catches done throughout 6 months intervention. Malaria infections occurred 61 subjects living 31 SR coil...
The success of mosquito-based malaria control is dependent upon susceptible bionomic traits in local vectors. It crucial to have accurate and reliable methods determine mosquito species composition areas subject malaria. An unexpectedly diverse set Anopheles was collected the western Kenyan highlands, including unidentified potentially new carrying parasite Plasmodium falciparum . This study identified 2,340 anopheline specimens using both ribosomal DNA internal transcribed spacer region 2...
The emergence of insecticide resistant Aedes aegypti mosquitoes has hampered dengue control efforts. WHO susceptibility tests, using several pyrethroid compounds, were conducted on Ae. larvae that collected and raised to adulthood from Semarang, Surakarta, Kudus Jepara in Java. AaNaV gene fragment encompassing kdr polymorphic sites both susceptible was amplified, polymorphisms associated with the phenotype. tests demonstrated Ae, resistance pyrethroids, mortality rates ranging 1.6%–15.2%....
Malaria is one of the most life-threatening infectious diseases worldwide and claims millions peoples life each year. The appearance drug-resistance Plasmodium falciparum has made treatment malaria increasingly problematic, thus, it a dire need to search new alternatives current drugs. In present study, 44 cassane- norcassane-type diterpenes isolated from Caesalpinia crista Myanmar Indonesia were evaluated for their antimalarial activity against parasite FCR-3/A2 clone in vitro. Most tested...
A deficiency in ADAMTS13 (a von Willebrand factor [VWF] cleaving protease) is associated with accumulation of prothrombogenic unusually large VWF multimers (UL-VWF) plasma. We studied release and proteolysis patients symptomatic Plasmodium falciparum or P. vivax malaria on the Indonesian island Sumba. Malaria had significantly lower platelet counts higher concentrations activation factors than healthy hospital staff controls. The latter indicates that a amount circulating was conformation...
The CH2Cl2 extract of the seed kernels Caesalpinia crista, which exhibited promising antimalarial activity against Plasmodium berghei-infected mice in vivo, was examined and resulted isolation seven new furanocassane-type diterpenes [caesalpinins C−G (1−5) norcaesalpinins D E (6, 7)] together with A−C (8−10) 11 known compounds (norcaesalpinins A−C, 2-acetoxy-3-deacetoxycaesaldekarin e, caesalmin B, caesaldekarin caesalpin F, 14(17)-dehydrocaesalpin 2-acetoxycaesaldekarin...
Abstract Background Accurate information about the burden of malaria infection at district or provincial level is required both to plan and assess local control efforts. Although many studies epidemiology, immunology, drug resistance have been conducted sites in Indonesia, there little published literature describing prevalence district, provincial, national level. Methods Two stage cluster sampling surveys were wet season dry across West Sumba, Nusa Tenggara Province, Indonesia. Results...
The Indonesian archipelago is endemic for malaria. Although Plasmodium falciparum and P. vivax are the most common causes malaria cases, malariae ovale also present in certain regions. Zoonotic case of had just became attention public health communities after Serawak study 2004. However, zoonotic Indonesia still under reported; only one published report knowlesi South Kalimantan 2010. A infection a worker from charcoal mining company Central Kalimantan, was described. suffered fever...
Plasmodium falciparum and vivax infections are important causes of adverse pregnancy outcomes in the Asia-Pacific region. We hypothesised that monthly intermittent preventive treatment (IPT) or screening (IST) with dihydroartemisinin-piperaquine is more effective reducing malaria than existing single (SST) strategy, which used to screen women for at first antenatal visit followed by passive case detection, management febrile cases.
Indonesia is home to a variety of malaria vectors whose specific bionomic traits remain largely uncharacterized. Species-specific behaviours, such as host feeding preferences, impact the dynamics transmission and effectiveness vector control interventions. To examine species-specific attraction Latin square design was used compare Anopheles mosquitoes attracted human, cow, goat-baited tents. were collected hourly from inside walls each baited tent. Species morphologically then molecularly...
Lead is one of ten hazardous chemicals public health concern and used in more than 900 occupations, including the battery, smelting, mining industries. toxicity accounts for 1.5% (900,000) deaths annually world. In Indonesia, reports high Blood Level (BLL) were associated with residency Used Acid Battery (ULAB) recycling sites. The present study aims to investigate BLL evidence lead children living an ULAB site Bogor Regency, Indonesia. A cross-sectional involving 128 aged 1–5 years was...
Malaria in pregnancy poses a major public health problem Indonesia with an estimated six million pregnancies at risk of Plasmodium falciparum or vivax malaria annually. In 2010, introduced screen and treat policy for the control first antenatal visit using microscopy rapid diagnostic tests (RDTs). A study was conducted Sumba, to compare performance four different RDTs predominately asymptomatic pregnant women under field condition. Women were screened visits HRP-2/pLDH combination...
Indonesia has set 2030 as its deadline for elimination of malaria transmission in the archipelago, with regional deadlines established according to present levels endemicity and strength health infrastructure. The Municipality Sabang which historically had one highest Aceh province aims achieve by end 2013. From 2008 2010, baseline surveys interventions, mapping all confirmed cases, categorization residual foci vector were conducted Sabang, Aceh, a pilot district Indonesia. To inform future...
Trichomonad species inhabit a variety of vertebrate hosts; however, their potential zoonotic transmission has not been clearly addressed, especially with regard to human infection. Twenty-one strains trichomonads isolated from humans (5 isolates), pigs (6 rodents water buffalo (1 isolate), cow goat and dog isolate) were collected in Indonesia molecularly characterized. The DNA sequences the partial 18S small subunit ribosomal RNA (rRNA) gene or 5.8S rRNA locus its flanking regions (internal...
The effectiveness of vector control efforts can vary based on the interventions used and local mosquito behaviour adaptability. In many settings, biting patterns Anopheles mosquitoes shift in response to targeting indoor-biting mosquitoes, often resulting higher proportions feeding outside or at times when people are not protected. These behaviourally resistant have been shown sustain residual malaria transmission limit efforts. Therefore, it is important accurately sample understand their...
Mosquitoes are important vectors that transmit pathogens to human and other vertebrates. Each mosquito species has specific ecological requirements bionomic traits impact exposure bites, hence disease transmission vector control. A study of biting mosquitoes their characteristics was conducted in West Sumba Southwest Districts, Nusa Tenggara Timur Province, Indonesia from May 2015 April 2018. Biweekly landing catches (HLC) night both indoors outdoors caught a total 73,507 specimens (59.7%...
Background and Aim: Zoonotic malaria is an emerging public health challenge in Indonesia, exacerbated by deforestation increased interaction between humans non-human primates (NHPs). This study aimed to estimate prevalence NHPs within the Buton Utara Wildlife Sanctuary (BUWS) evaluates potential risk of zoonotic transmission nearby human populations. Materials Methods: Epidemiologic surveys were conducted from 2020 2021 BUWS. Macaca brunnescens, endemic NHP species, captured using traps....
Evaluating long-term immunity after COVID-19 infection and vaccination is critical for managing potential outbreaks. The aim of this study was to develop a cost-effective in-house enzyme-linked immunosorbent assay (ELISA) based on Escherichia coli-expressed SARS-CoV-2 spike protein (E-S1) antibody detection evaluate its performance. system validated by comparing the ELISA results with those obtained using commercial HEK293-expressed (H-S1). Recombinant produced in E. coli, purified,...