A5064498690- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- CRISPR and Genetic Engineering
- Breast Cancer Treatment Studies
- Refrigeration and Air Conditioning Technologies
- Ion channel regulation and function
- Axon Guidance and Neuronal Signaling
- Erythrocyte Function and Pathophysiology
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Heat Transfer and Boiling Studies
- Retinoids in leukemia and cellular processes
- Genetics and Neurodevelopmental Disorders
- EEG and Brain-Computer Interfaces
- Advanced Sensor Technologies Research
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Glutathione Transferases and Polymorphisms
- Epilepsy research and treatment
Second Affiliated Hospital of Zhejiang University
2025
Johns Hopkins Medicine
2017-2024
Discovery Institute
2020-2024
Johns Hopkins University
2017-2024
Institute of Biophysics
2015-2021
State Key Laboratory of Brain and Cognitive Science
2021
Chinese Academy of Sciences
2015-2016
University of Chinese Academy of Sciences
2015
Affiliated Hospital of Taishan Medical University
2015
First Affiliated Hospital of Xinjiang Medical University
2014
SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for plasticity, learning, memory, and cognition. Mutations in SYNGAP1 humans result intellectual disability, autistic-like behaviors, epilepsy. Heterozygous Syngap1 -knockout mice display deficits memory exhibit seizures. It unclear whether imparts structural properties at synapses independently of its GAP activity. Here, we report that inactivating mutations within the domain do not inhibit plasticity or cause...
Elucidating how synaptic molecules such as AMPA receptors mediate neuronal communication and tracking their dynamic expression during behavior is crucial to understand cognition disease, but current technological barriers preclude large-scale exploration of molecular dynamics in vivo. We have developed a suite innovative methodologies that break through these barriers: new knockin mouse line with fluorescently tagged endogenous receptors, two-photon imaging hundreds thousands labeled...
To investigate how etiology and seizure localization influence ictal scalp electroencephalographic (EEG) patterns in temporal lobe epilepsy (TLE). We retrospectively analyzed EEG features from 504 focal seizures recorded 189 TLE patients with various etiologies who underwent resective surgery. For onset (SOPs), α/β was more common the low-grade tumor group (38.4%) than hippocampal sclerosis (HS) (14.1%, p < 0.001). The duration shorter compared to cortical dysplasia (FCD), HS, non-specific...
Hebbian plasticity is a key mechanism for higher brain functions, such as learning and memory. This form of synaptic primarily involves the regulation α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) abundance properties, whereby AMPARs are inserted into synapses during long-term potentiation (LTP) or removed depression (LTD). The molecular mechanisms underlying AMPAR trafficking remain elusive, however. Here we show that glutamate interacting protein 1 (GRIP1), an...
Significance Throughout an organism’s life span, neural circuits mediate sensory and cognitive processing via synaptic plasticity, which involves synapse-specific Hebbian plasticity network-level homeostatic plasticity. Synaptic strengthening weakening are finely tuned by changes in postsynaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) -type glutamate receptors (AMPARs). We have elucidated a biochemical regulation of AMPARs that is specific to while sparing mechanisms....
Significance Compared with vesicle exocytosis and endocytosis, relatively little is known about recycling. Here, we developed a novel methodological approach, potentially applicable to all axosomatic synapses, quantify the kinetics of recycling exquisite signal temporal resolution. Using this approach combined electron-microscopic observations, estimated that ∼80% synaptic vesicles participate in provided an explanation reconcile discrepancies previous reports. We kinetically dissected...
The aim of the present study was to investigate expression estrogen receptor β (ERβ) in triple-negative and triple-positive breast cancer patients, evaluate its utility as a prognostic factor. Between January 2000 December 2010, primary tumor tissue samples were collected from 234 subjects, including 107 127 patients. embedded paraffin immunohistochemical staining conducted determine levels ERβ. Kaplan-Meier method used analyze patient survival rates. ERβ observed 38/107 patients (35.5%)...
Abstract Elucidating how synaptic molecules such as AMPA receptors mediate neuronal communication and tracking their dynamic expression during behavior is crucial to understand cognition disease, but current technological barriers preclude large-scale exploration of molecular dynamics in vivo. We have developed a suite innovative methodologies that break through these barriers: new knockin mouse line with fluorescently tagged endogenous receptors, two-photon imaging hundreds thousands...
Abstract This paper presents a one-dimensional homogenous model of high power-density XeCl excilamp pumped by dielectric barrier discharge (DBD) with larger gap and lower Cl 2 density in Xe/Cl mixture, to research the electrical chemical characteristics leading production XeCl* molecules for optimal parameters. The peaked wavelength 308 nm from emission band exciplex molecules, show great promise as photochemotherapy biomedicine applications. temporal evolutions plasma voltage, current...