A5034935219- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Asymmetric Synthesis and Catalysis
- Synthesis and Biological Activity
Hospital Universitario Dr José Eleuterio Gonzalez
2021
Universidad de La Laguna
2018-2021
Laguna Research
2021
A direct and general method for the synthesis of naturally occurring 2,3,4,5,6-pentasubstituted tetrahydropyrans has been developed, employing β,γ-unsaturated N-acyl oxazolidin-2-ones as key starting materials. The combination Evans aldol addition Prins cyclization allowed diastereoselective efficient generation desired oxacycles in two fashions: a one-pot aldol–Prins protocol, which five new σ bonds contiguous stereocenters were straightforwardly generated, two-step version, additionally...