Ranolazine is a novel anti-anginal drug used in the treatment of chronic stable angina adults. The present study was designed with an objective to develop and validate simple, fast, precise, selective accurate Reverse phase high performance liquid chromatography (RP-HPLC) method for quantitative estimation bulk drugs selected dosage forms. efficient chromatographic separation achieved on SunShell C18 column (150mm X 4.6mm, 2.6μm particle size) as stationary mobile consisting buffer (0.01M...

The present study is focused on the availability of microbial sources capable producing xylanase, a hemicelluloses-degrading enzyme with multiple modes action along specificity, and their real-world applications. For accumulation suitable data, article surfing was carried out using search engines viz. Hinari PubMed; irrelevant duplicate articles were discarded summarized in narrative way herein. This review written aiming to bridge recent research activities commercial xylanase going around...

This study was carried out to develop matrix based transdermal patches containing Atenolol. A 2 factors (HPMC (hydroxyl propyl methyl cellulose) K4M & PVP (Polyvinyl Pyrolidone) 3 level (2 ) factorial design done using Design Expert® which gave 13 experiments. The were prepared by Solvent casting method. Propylene glycol (3%) and Tween 80 (6%) used as plasticizer permeation enhancer respectively. Physicochemical characteristics In-Vitro of formulated out. Contour plot suggested 770 mg...

p>A hydroxypropyl methylcellulose (HPMC K4M, HPMC K15M, and K100M) matrix tablet containing Indomethacin along with mannitol was formulated as a function of viscosity, compared the commercial products. The release characteristics were investigated in intestinal fluid, 6.8 pH phosphate buffer for 12 hours. products two marketed reference sample studied its different physicochemical parameters vitro dissolution studies. It found that drug profile decreases increase viscosity polymer and,...

Domperidone Maleate (DOM), an antiemetic drug, has been used in treatment of adults and children. It low aqueous solubility hence bioavailability. In present study, attempt made to enhance the DOM by inclusion complexation with Hydroxypropyl-β-Cyclodextrin (HP-β-CD) using kneading technique formulation fast disintegrating tablets Sodium Starch Glycolate as superdisintegrant. Solubility analysis different concentrations HP-β-CD was carried out. Design experiment (DOE) is done MINITAB 15.1...

The effect of combination PG with DMSO, BC, IPM, Tween 80 and SLS on drug release rate was studied in vitro. mechanism also by using power law. Significant difference (One way ANOVA; p<0.05) among the 16 formulations seen study. profiles various showed that added enhancers individual batches affect drug. concentration DMSO directly proportional where as BC inversely relationship rate. increase followed decrease IPM concentration. In most formulations, occurred diffusion partially through...

Human Epidermal Growth Factor Receptor 2 (HER2/neu) is one of the most extensively studied proto-oncogens in breast cancer patients. Accurate and timely assessment HER2/neu over expression pivotal for identification patients that could benefit from HER2-targeted therapy. The present study was undertaken to investigate diagnostic utility serum testing by chemiluminescent immunoassay (CLIA) compare it with immunohistochemistry (IHC) method expression.Serum sample tissue/paraffin block...

This study was done to mask the bitter taste of ondansetron HCl using complexing agent, a polacrilex resin: Tulsion 335 and subsequently forming mouth dissolving tablet superdisintegrants: Croscarmellose sodium starch glycollate. A preliminary screening done. Batch process, most preferential method for drug loading with ion exchange resins selected. The process optimized drug: resin ratio get maximum loading. at 1:3 Taste evaluation carried out by selecting volunteers. Drug complex (DRC)...

Dabigatran is an oral prodrug used for the prevention of venous thromboembolic events or stroke; a life-saving drug.The aim present study was to ensure in vivo performance dabigatran capsules marketed Nepal.The predicts data locally produced (coded as Product A and B which are without using In Vitro Vivo correlation (IVIVC) method.From predicted plasma drug concentration-time data, Area Under Curve (AUC), maximum concentration (Cmax) were determined both test products numerical convolution...

In order to improve the low permeability associated with conventional or immediate release dosage forms such as nasal spray and oral solid form, tablets, fexofenadine liposomes were prepared by using ethanol injection method varying concentration of surfactant, (Tween -80), along crude lecithin cholesterol. The optimized formulations was evaluated for size, shape, entrapment efficiency in vitro drug release. this study formulated appeared be spherical shape particle size found 4703.667±445...

The main objective of this study was to scale up xylanase production from isolated soil microbe (Brevibacillus borselensis; the Microbial Type Culture Collection (MTCC) 9874) in a bioreactor and check digestibility crude enzyme animal feed (wheat).Scale done lab Xylanolytic activity is greater than flask method due more controlled condition which not possible method.Digestibility checked wheat found that 16 (15.797)times digestion will be increased if it supplemented with produced given...

The lower residence contact time of drug, higher tear turnover, limited surface area and impermeability corneal epithelium layer are the reasons poor bioavailability conventional ophthalmic dosage forms.The purpose this study is to formulate ciprofloxacin hydrochloride (HCl) in situ gelling drug delivery system based on pH fluid for better minimising frequent instillation.This includes sensitive polymer (Carbopol 934p) as a agent HPMCK15M viscosity enhancer which instilled drop undergo...

Divalproex sodium (DS), being a hygroscopic drug, requires low humidity during product manufacturing. This study aims to develop hygroscopicity controlled sustained release formulation of DS that can be manufactured in relatively high humid conditions facilities lacking dehumidifiers.This focuses on the role polyethylene glycol (PEG-8000) and hydroxypropyl methylcellulose (HPMC K100M) as polymers choice control retard using solid dispersion technique. In this study, homogeneous dispersions...

Objectives: We aimed to formulate and optimize bilayer tablets of metoprolol tartrate consisting both immediate sustained release layer. Methods: A 23 factorial design was employed in formulating the GFDDS which parameters, such as amount HPMC (X1), sodium bicarbonate + citric acid (X2), crospovidone (X3) were characterized independent variables, whereas percent at 30 min (Y1), 4 hr (Y2), 8 (Y3), floating lag time (Y4), total (Y5) considered dependent variables. Findings: The formulations...

Introduction: Six-sigma is emerging method of choice for performance testing clinical laboratory. This study was designed to evaluate the 12 routine biochemical analytes on sigma-scale and calculate quality goal index (QGI). Methods: A cross-sectional conducted at Tribhuvan University Teaching Hospital (TUTH), Biochemistry Laboratory 3 months. BT1500 BT3500 automated biochemistry analyzers were used. Internal control (IQC) performed routinely both levels recorded from used calculation...