With the Internet of Things (IoT) becoming part our daily life and environment, we expect rapid growth in number connected devices. IoT is expected to connect billions devices humans bring promising advantages for us. this growth, fog computing, along with its related edge computing paradigms, such as multi-access (MEC) cloudlet, are seen solutions handling large volume security-critical time-sensitive data that being produced by IoT. In paper, first provide a tutorial on including their...

CONTEXT Telemedicine is a promising but largely unproven technology for providing case management services to patients with chronic conditions and lower access care. OBJECTIVES To examine the effectiveness of telemedicine intervention achieve clinical goals in older, ethnically diverse, medically underserved diabetes. DESIGN, Setting, Patients A randomized controlled trial was conducted, comparing usual care, blinded outcome evaluation, 1,665 Medicare recipients diabetes, aged >/= 55 years,...

Background: Resident-to-resident elder mistreatment (R-REM) in nursing homes can cause physical and psychological injury death, yet its prevalence remains unknown. Objective: To estimate the of physical, verbal, sexual R-REM home residents subgroups. Design: 1-month observational study. Setting: 5 urban suburban New York state homes. Participants: 2011 10 facilities randomly selected on basis size location; 83% 84% eligible participated. Measurements: was identified through resident...

There is a growing body of evidence that the nondegradable fluorophores accumulate as lipofuscin retinal pigment epithelium (RPE) are involved in mechanisms leading to degeneration RPE macular degeneration. Most constituents inadvertent products retinoid visual cycle, enzymatic pathway by which 11- cis -retinal chromophore rhodopsin generated. Indeed, major constituent lipofuscin, pyridinium bisretinoid A2E, diretinal conjugate forms photoreceptor cells and deposited consequence phagocytosis...

To examine whether improved diabetes control is related to better cognitive outcomes.

Purpose.: Excessive accumulation of lipofuscin is associated with pathogenesis atrophic age-related macular degeneration (AMD) and Stargardt disease. Pharmacologic inhibition the retinol-induced interaction retinol-binding protein 4 (RBP4) transthyretin (TTR) in serum may decrease uptake retinol to retina reduce formation bisretinoids. We evaluated vitro vivo properties new nonretinoid RBP4 antagonist, A1120. Methods.: binding potency, ability antagonize RBP4-TTR interaction, compound...

Importance Black and Hispanic patients have high rates of recurrent stroke uncontrolled hypertension in the US. The effectiveness home blood pressure telemonitoring (HBPTM) telephonic nurse case management (NCM) among low-income with is unknown. Objective To determine whether NCM plus HBPTM results greater systolic (SBP) reduction at 12 months lower rate recurrence 24 than alone survivors hypertension. Design, Setting, Participants Practice-based, multicenter, randomized clinical trial 8...

Globin mRNAs accumulate to 95% of total cellular mRNA during terminal erythroid differentiation, reflecting their extraordinary stability. The stability human α-globin is paralleled by formation a sequence-specific RNA-protein (RNP) complex at pyrimidine-rich site within its 3′ untranslated region (3′UTR), the α-complex. proteins α-complex are widely expressed. or closely related also assembles 3′UTR segments other stable mRNAs. These data suggest that may constitute general determinant One...

The accumulation of the lipofuscin fluorophores in retinal pigment epithelial (RPE) cells leads to blinding degeneration characteristic Stargardt disease and related forms macular degeneration. RPE lipofuscin, including fluorophore A2E, large part as a byproduct visual cycle. Inhibiting cycle function with small molecules is required prevent formation retinotoxic lipofuscins. This turn requires identification rate-limiting steps operation Specific, non-retinoid isoprenoid compounds are...

In Brief Background. To study whether C57BL/6J-Tyrc−2j/J (C2J) mouse embryonic stem (ES) cells can differentiate into retinal pigment epithelial (RPE) in vitro and then restore function a model for retinitis pigmentosa: Rpe65rd12/Rpe65rd12 C57BL6 mice. Methods. Yellow fluorescent protein (YFP)-labeled C2J ES were induced to RPE-like structures on PA6 feeders. RPE-specific markers are expressed from differentiated vitro. After differentiation, cell-derived transplanted the subretinal space of...

Network function virtualization (NFV) provides an efficient and flexible way to deploy network services in the form of service chains (SFCs) by adopting generalized equipment. However, software-based virtualized functions (VNFs) bring new challenge for operators providing availability guarantees. Traditionally, network-level protection mechanisms are considered separately from function-level VNF backup mechanisms. a SFC's cannot be guaranteed if only network- level or considered. In this...

Deficiencies in stroke preparedness cause major delays to thrombolysis, particularly among economically disadvantaged minorities. We evaluated the effectiveness of a intervention delivered preadolescent urban public school children on knowledge/preparedness their parents.We recruited 3070 fourth through sixth graders and 1144 parents from 22 schools into cluster randomized trial with HHS (Hip-Hop Stroke) or attentional control (nutrition classes). is 3-hour culturally tailored, theory-based,...

purpose. Approximately 8% of autosomal recessive retinitis pigmentosa (RP) cases worldwide are due to defects in rod-specific phosphodiesterase PDE6, a tetramer consisting catalytic (PDE6α and PDE6β) two regulatory (PDE6γ) subunits. In mice homozygous for nonsense Pde6b rd1 allele, absence PDE6 activity is associated with retinal disease similar humans. Although studied 80 years, the rapid degeneration phenotype has limited analyses therapeutic modeling. Moreover, this model does not...

The expression of an mRNA is strongly impacted by its 3' poly(A) tail and associated poly(A)-binding proteins (PABPs). Vertebrates encode six PABP isoforms that vary in abundance, distribution, developmental control, subcellular localization. Here we demonstrate the minor isoform PABPC4 expressed erythroid cells impacts steady-state a subset mRNAs. Motif analyses reveal high-value AU-rich motif untranslated regions (UTRs) PABPC4-impacted This enhances association with mRNAs containing...

Abstract In Drosophila melanogaster there are two genes encoding ribosomal protein S5, RpS5a and RpS5b . Here, we demonstrate that is required for oogenesis. Females lacking produce ovaries with numerous developmental defects undergo widespread apoptosis in mid-oogenesis. germline fully fertile, but expression of interfering RNA targeting an mutant background worsened the phenotype blocked oogenesis before egg chambers form. A broad spectrum mRNAs co-purified immunoprecipitations RpS5a,...

We examine the changes in waist circumference (WC) and body mass index (BMI) older adults enrolled a diabetes telemedicine program. The subjects were elderly Medicare beneficiaries participating rural (upstate New York) cohort of Informatics Diabetes Education Telemedicine, randomized, controlled trial using to improve care which primary outcome was glycemic control.Ninety-two percent had BMI >25 kg/m(2), 65.8% > or =30 kg/m(2). Intervention received home televisits with dietitian nurse...

We examined the social impact of telemedicine intervention effects in lower- and higher-socioeconomic status (SES) participants Informatics for Diabetes Education Telemedicine (IDEATel) study.We conducted a randomized controlled trial comparing case management with usual care, blinded outcome evaluation, 1665 Medicare recipients diabetes, aged 55 years or older, residing federally designated medically underserved areas New York State. The primary endpoints were hemoglobin A1c (HbA1c),...

OBJECTIVE The Northern Manhattan Diabetes Community Outreach Project evaluated whether a community health worker (CHW) intervention improved clinically relevant markers of diabetes care in adult Hispanics. RESEARCH DESIGN AND METHODS Participants were Hispanics, ages 35-70 years, with recent hemoglobin A1c (A1C) ≥8% (≥64 mmol/mol), from university-affiliated network primary practices northern (New York City, NY). They randomized to 12-month CHW (n = 181), or enhanced usual (educational...

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and selectively degrades mRNAs carrying premature termination codons (PTCs). The level of sensitivity PTC-containing to NMD multifactorial. We have previously shown human β-globin PTCs in close proximity the translation initiation AUG codon escape NMD. This was called 'AUG-proximity effect'. present analysis nonsense α-globin illustrates determinants AUG-proximity effect are fact quite complex, reflecting ability...

A primary pathological defect in the heritable eye disorder Stargardt disease is excessive accumulation of cytotoxic lipofuscin bisretinoids retina. Age-dependent retinal pigment epithelium (RPE) matches age-dependent increase incidence atrophic (dry) form age-related macular degeneration (AMD) and therefore may be one several pathogenic factors contributing to AMD progression. Lipofuscin bisretinoid synthesis retina depends on influx serum retinol from circulation into RPE. Formation...

Goldmann-Favre syndrome, also known as enhanced S-cone is an inherited retinal degeneration disease in which a gain of photoreceptor cell types results dysplasia and degeneration. Although microglia have been implicated the pathogenesis many neurodegenerative diseases, fundamental role these cells this unknown. In current study, sequential analyses suggest that are recruited appear after outer nuclear layer folding. By crossing rd7 mice (a model for hereditary owing to Nr2e3 mutation) with...

Objectives To compare the effectiveness of 2 caregiver interventions with known efficacy: Resources for Enhancing Caregiver Health‐Offering Useful Treatment (REACH‐OUT) and New York University Intervention (NYUCI). Design 1:1 randomized pragmatic trial. Setting City. Participants Informal Hispanic caregivers persons dementia (N=221; mean age 58.2, 82.8% female, 63.3% adult children, 31.7% spouses). were to 6 months NYUCI (n=110) or REACH‐OUT (n=111), balanced on characteristics at baseline....

We propose a proactive dynamic network slicing scheme that utilizes deep-learning based short-term traffic prediction approach for 5G transport networks. The demonstration shows utilization efficiency improvement from 46.33% to 71.53% under the evaluated scenario.