A5071562071- Plant Gene Expression Analysis
- Mycobacterium research and diagnosis
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Horticultural and Viticultural Research
- Fermentation and Sensory Analysis
- Acute Myeloid Leukemia Research
- Biochemical and biochemical processes
- Infectious Diseases and Mycology
- Plant biochemistry and biosynthesis
- Tuberculosis Research and Epidemiology
- Microtubule and mitosis dynamics
- Antibiotic Resistance in Bacteria
- Actinomycetales infections and treatment
- Glycosylation and Glycoproteins Research
- Bacterial Genetics and Biotechnology
- Vibrio bacteria research studies
- Ginseng Biological Effects and Applications
- Lung Cancer Research Studies
- Carbohydrate Chemistry and Synthesis
- Genomics and Rare Diseases
- Escherichia coli research studies
- Neurofibromatosis and Schwannoma Cases
Centre Hospitalier Universitaire Sainte-Justine
2016-2023
Université d'Angers
2020
Inserm
2020
Centre Hospitalier Universitaire d'Angers
2020
Université d'Abomey-Calavi
2020
Centre Pasteur du Cameroun
2020
Nantes Université
2020
Sciences pour L’Œnologie
2011-2018
Laboratoire Microorganismes Génome et Environnement
2015
Centre National de la Recherche Scientifique
2015
Grape proanthocyanidins (PAs) play a major role in the organoleptic properties of wine. They are accumulated mainly grape skin and seeds during early stages berry development. Despite recent progress identification genes involved PA biosynthesis, mechanisms subunit condensation, galloylation, or fine regulation spatio-temporal composition berries PAs still not elucidated. Two Myb transcription factors, VvMybPA1 VvMybPA2, controlling pathway have recently been identified ectopically...
<h3>Importance</h3> Little progress in pediatric cancer treatment has been noted the past decade, urging development of novel therapeutic strategies for adolescents and children with hard-to-treat cancers. Use comprehensive molecular profiling clinical management appears a suitable approach to improve patient care outcomes, particularly cases. <h3>Objective</h3> To assess feasibility identifying potentially actionable mutations using next-generation sequencing–based assays clinically...
Chaperone/usher (CU) assembly pathway is used by a wide range of Enterobacteriaceae to assemble adhesive surface structures called pili or fimbriae that play role in bacteria-host cell interactions. In silico analysis revealed the genome Klebsiella pneumoniae LM21 harbors eight chromosomal CU loci belonging γκп and ϭ clusters. Of these, only two correspond previously described operons, namely type 1 3-encoding operons. Isogenic usher deletion mutants K. were constructed for each locus their...
Abstract Background Alterations of FLT3 are among the most common driver events in acute leukaemia with important clinical implications, since it allows patient classification into prognostic groups and possibility personalising therapy thanks to availability inhibitors. Most knowledge on implications comes from study myeloid so far, few studies have been performed other leukaemias. Methods A comprehensive genomic (DNA-seq 267 patients) transcriptomic (RNA-seq 160 analysis 342 childhood...
Pilocytic astrocytoma (PA) is emerging as a tumor entity with dysregulated RAS/RAF/MEK/ERK signaling. In this study, we report the identification of novel recurrent BRAF insertion (p.V504_R506dup) in five PA cases harboring exclusively somatic tandem duplication. This alteration leads to an addition three amino acids kinase domain and has functional impact on activating MAPK phosphorylation. Importantly, show that mutation confers resistance RAF inhibitors without changing effectiveness...
Abstract Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical disease found in rural areas West and Central Africa. Despite ongoing efforts to tackle ulcer epidemics, environmental reservoir its pathogen remains elusive, underscoring need for new approaches improving prevention management. In our study, we implemented local-scale spatial clustering model deciphered genetic diversity bacteria small area Benin where endemic. Using 179 strain samples from Africa,...
We demonstrate the production of skin-specific antibodies with neutralizing activity against mycolactone toxin.
Abstract Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical disease found in rural areas West and Central Africa. Despite ongoing efforts to tackle ulcer epidemics, environmental reservoir its pathogen remains elusive, underscoring need for new approaches improving prevention management. In our study, we implemented local-scale spatial clustering model deciphered genetic diversity bacteria small area Benin where endemic. Using 179 strain samples from Africa,...
Abstract In Canada, about 1500 pediatric cancers are diagnosed each year. Despite improvements in risk-stratified treatments, around 20% of childhood cancer patients do not respond to current therapies and ultimately succumb their disease, urging the need for new more effective therapeutic approaches. Personalized targeted therapy (PTT) based on next generation sequencing (NGS) may be a key component increase cure rates decrease treatment-related morbidity mortality. To assess feasibility...
Abstract Childhood cancer is a group of heterogeneous complex diseases. Although 80% these children are cured with conventional therapies, it remains the first cause death among in Western countries. A significant number refractory/relapse patients will eventually succumb to their disease and lack therapeutic advances for even more worrisome. Indeed, no progress has been noted over last decade patients, urging need new effective approaches. Precision medicine personalized targeted therapies...