✓ In a series of 33 patients with reasonably controlled primary cancers, stereotactic radiosurgery was used to treat 52 brain metastases. After mean radiological follow-up time 5.5 months, six lesions (12%) had stabilized in size, 26 (50%) were significantly reduced, and 15 (29%) disappeared. One large melanoma metastasis progressed relentlessly despite treatment. Five (9%) decreased size slightly before enlarging. two these lesions, biopsy revealed only necrosis. almost all cases, treatment...

Abstract Objectives There is limited research on thyroid function in pediatric patients with cystic fibrosis (pwCF). This study aimed to determine the frequency of dysfunction children and adolescents CF evaluate iodine deficiency selenium status pwCF. Methods Sixty-two 62 control subjects were evaluated. The anthropometric measurements, nutritional status, FEV1(Forced-expiratory-volume 1 s) percentage, tests (TSH, FT4, FT3), urinary levels, hospitalization last six months, antibiotic usage,...

The aim of this study was to investigate novel urinary biomarkers including N-acetyl-β-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and liver-type fatty acid binding protein (L-FABP) in children with β-thalassemia major (β-TM).Totally, 52 patients (29 boys, 23 girls) β-TM 29 healthy controls (3-17 years) were included. Various demographic characteristics blood transfusions/year, disease duration, chelation therapy recorded....

Background:This study was designed to evaluate the effects of carvacrol (CRV) and pomegranate extract (PE) on methotrexate (MTX)-induced lung injury in rats. Material andMethods:A total 32 male rats were subdivided into 4 groups: control (group I), MTX treated II), MTX+CRV III), MTX+PE IV). A single dose 73 mg/kg CRV administered intraperitoneally group III Day 1 investigation. To IV, a 225 PE via orogastric gavage once daily over 7 days. 20 given groups II, III, IV 2. The duration...

New tumour biomarkers are being intensely investigated for malignant mesothelioma (MM). Fibulin-3 is produced in MM but its role remains uncertain. The aim of this study was to evaluate the validity measuring serum fibulin-3 diagnosis and prognosis MM.This prospective performed on 43 patients 40 healthy controls who were admitted our hospital between January 2012 2014. Data from patients, including demographic clinical features, routine laboratory data, levels fibulin-3, treatment outcomes...

The goal of our study was to determine the therapeutic effects thymoquinone in a dose-dependent manner model neuropathic pain following an experimentally applied spinal cord injury (SCI). Fifty female adult Wistar albino rats weighing between 220 and 260 g were included divided into 5 groups as follows: Group S (sham), C (control), T100 (100 mg/kg thymoquinone), T200 (200 T400 (400 thymoquinone). To begin experiment, SCI all (with exception sham group) mechanical heat–cold test. Two weeks...

To investigate the therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis in rats.Thirty-two were split into four groups. Group 1 (control) rats performed only laparotomy, no drugs administered. 2 (control+EA) administered 85mg/kg EA orally. Rats sacrificed by cardiac puncture 24 hours after administration. Group3 (AP) intraperitoneal L-arginine administration, puncture. 4 (EA)-(AP): was orally later, Serum TNF-α, IL-1β, IL-6, total oxidative status (TOS), antioxidant...

To investigate the role of cordycepin in testicular ischemia/reperfusion injury rats.Forty Wistar albino rats were randomly divided into four groups, as follows: group one, control (C); two, torsion and ischemia (I); three: detorsion with ischemia-reperfusion (IR); four, detorsion/cordycepin. The then analyzed macromorphologically histopathologically, blood tests performed. Specifically, total oxidant status (TOS) antioxidant (TAS) determined, malondialdehyde (MDA), tumor necrosis factor...

<b><i>Objective:</i></b> Oxidative stress has been reported to play a role in the psychopathology of schizophrenia, though only few studies have investigated relationship between early-onset schizophrenia and oxidative stress. The aim present study is evaluate level presence DNA damage first-episode psychosis (FEP) adolescents. <b><i>Methods:</i></b> This was conducted Department Child Psychiatry Dicle University Hospital. It included 20...

Eighteen finger pulp defects were reconstructed using a homodigital dorsal middle phalangeal neurovascular island flap procedure based on single pedicle preserving the length of finger. All flaps survived and achieved adequate functional cosmetic results. The mean follow-up time was 22 months. value static two-point discrimination test healed 7 mm moving 5 mm. Range motion considered satisfactory in all fingers except one, which 20 degree extension deficit at proximal interphalangeal joint...

This study aimed to evaluate changes in the autonomic nervous system caused by cerebral lesions due acute stroke. We assessed heart rate variability and catecholamine levels lieu of stroke lesion localization.A total 60 patients 31 healthy controls were enrolled study. Plasma epinephrine norepinephrine measured on first, third, seventh days following event. Heart was evaluated with time-domain frequency-domain analyses via 24-hour Holter monitor recordings.On first third day stroke,...

Chronic hepatitis B (CHB) is a global health problem that can result in serious complications associated with collagen degradation. Prolidase specific imidodipeptidase plays an important role the breakdown of collagen. The aim this study was to investigate prolidase activity and oxidant-antioxidant status children CHB.This prospective case control includes 38 patients CHB, 31 inactive (IHB), 29 healthy matched subjects. Serum enzyme (SPEA), total antioxidant capacity (TAC), oxidative (TOA),...

Human serum paraoxonase (PON1) prevents lipids from peroxidation and functions as an antioxidant mechanism. Malonyldialdehyde (MDA) is the final product of lipid can be used indicator oxidative stress. The aim this study was to investigate PON1, MDA, arylesterase (ARY) levels in schizophrenic patients who are taking typical, atypical, or combined (typical atypical) antipsychotic drug treatment, with respect those healthy controls.We evaluated 41 (11 typical antipsychotics, 19 atypical 11...

In this study, we investigated serum brain-derived neurotrophic factor (BDNF), adrenocorticotropic hormone (ACTH), and cortisol levels between children with obsessive-compulsive disorder (OCD) prior to treatment healthy controls. addition, the study aimed assess any correlations OCD symptom severity BDNF, ACTH, levels.Twenty-nine children, aged from 7 17 years (male/female: 21/8) diagnosed according DSM-IV treatment, were compared 25 control subjects 16/9). The was conducted December 2012...

Objective The aim of this study was to investigate whether cortisol and oxidative stress levels DNA damage differ between individuals who developed PTSD or not following a sexual trauma. Methods included 61 children aged 5 17 years sustained abuse (M/F: 18/43). patients were divided into two groups: with without based, based on the results structured psychiatric interview (K-SADS-PL CAPS-CA). Cortisol, glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q,...