A5073592752- Hungarian Social, Economic and Educational Studies
- Migraine and Headache Studies
- Plant Stress Responses and Tolerance
- Plant Reproductive Biology
- Genetic and Kidney Cyst Diseases
- Renal Diseases and Glomerulopathies
- Nail Diseases and Treatments
- Plant Physiology and Cultivation Studies
- Photosynthetic Processes and Mechanisms
- Light effects on plants
- Agriculture, Plant Science, Crop Management
- Regional Development and Policy
- Renal and related cancers
- Autoimmune Bullous Skin Diseases
- Plant Virus Research Studies
- Urinary Tract Infections Management
- Flowering Plant Growth and Cultivation
- Powdery Mildew Fungal Diseases
- Microencapsulation and Drying Processes
- Pneumonia and Respiratory Infections
- RNA modifications and cancer
- Plant Pathogens and Fungal Diseases
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Pneumocystis jirovecii pneumonia detection and treatment
National Institute of Menthal Health, Neurology and Neurosurgery - Nyírő Gyula Hospital
2024
Agricultural Institute
2021-2023
Centre for Agricultural Research
2020-2023
Károli Gáspár University of the Reformed Church in Hungary
2022
Corvinus University of Budapest
2022
Hungarian Research Network
2021
Semmelweis University
2007-2020
Országos Pszichiátriai és Neurológiai Intézet
2020
Hungarian Academy of Sciences
2020
Plant Protection Institute
2020
RNA modifications play a fundamental role in cellular function. Pseudouridylation, the most abundant modification, is catalyzed by H/ACA small ribonucleoprotein (snoRNP) complex that shares four core proteins, dyskerin (DKC1), NOP10, NHP2, and GAR1. Mutations DKC1 , NOP10 or NHP2 cause dyskeratosis congenita (DC), disorder characterized telomere attrition. Here, we report phenotype comprising nephrotic syndrome, cataracts, sensorineural deafness, enterocolitis, early lethality two pedigrees:...
In the present study, we identified and characterized apricot (Prunus armeniaca L.) homologs of three dormancy-related genes, namely ParCBF1 (C-repeat binding factor), ParDAM5 (dormancy-associated MADS-BOX) ParDAM6 genes. All highly conserved structural motifs 3D model DNA-binding domain indicate an unimpaired ability ParCBF1. A phylogenetic analysis showed that was most likely homologous to Prunus mume dulcis CBF1. also contained all characteristic domains type II (MIKCC) subfamily MADS-box...
Abstract Upon virus infections, the rapid and comprehensive transcriptional reprogramming in host plant cells is critical to ward off attack. To uncover genes defense pathways that are associated with resistance, we carried out transcriptome-wide Illumina RNA-Seq analysis of pepper leaves harboring L 3 resistance gene at 4, 8, 24 48 h post-inoculation (hpi) two tobamoviruses. Obuda (ObPV) inoculation led hypersensitive reaction (incompatible interaction), while Pepper mild mottle (PMMoV)...
Abstract Effects of ascorbate (ASA) and hydrogen peroxide (H 2 O ) on metabolite profile was compared in wheat. Interestingly, the redox environment became more oxidized after ASA treatment reduced H addition based ratios oxidised glutathione. The excess could inhibit, while induce oxidative pentose phosphate pathway producing reducing power as shown by unchanged decreased glucose-6-phosphate content, respectively. This different effect content can also explain formation several amino acids...
This study aimed to clarify whether the light condition-dependent changes in redox state and subcellular distribution of glutathione were similar dicotyledonous model plant Arabidopsis (wild-type, ascorbate- glutathione-deficient mutants) monocotyledonous crop species wheat (Chinese Spring variety). With increasing intensity, amount its reduced (GSH) oxidized (GSSG) form GSSG/GSH ratio increased leaf extracts both including all genotypes, while far-red these parameters only except for GSH...
Abstract Background: Nephronophthisis, an autosomal recessive nephropathy, is responsible for 10% of childhood chronic renal failure. The deletion its major gene, NPHP1 , with a minor allele frequency 0.24% in the general population, most common mutation leading to monogenic form It challenging detect it heterozygous state. We aimed evaluate sensitivity and specificity quantitative multiplex PCR short fluorescent fragments (QMPSF) detection. Methods: After setting up protocol QMPSF, we...
Tension type headache, the most common of primary headaches, affects approximately 80% population. Mainly because its high prevalence, socio-economic consequences tension headache are significant. The pain in is usually bilateral, mild to moderate, a pressing or tightening quality, and not accompanied by other symptoms. Patients with frequent daily occurrence may experience significant distress condition. two main therapeutic avenues acute prophylactic treatment. Simple combined analgesics...
Abstract We assumed that miRNAs might regulate the physiological and biochemical processes in plants through their effects on redox system phytohormones. To check this hypothesis, transcriptome profile of wild‐type Arabidopsis lines with decreased ascorbate (Asc), glutathione (GSH), or salicylate (Sal) levels were compared. GSH deficiency did not influence miRNA expression, whereas lower Asc Sal reduced accumulation 9 44 miRNAs, respectively, but only four upregulated. Bioinformatics...
Spectral quality, intensity and period of light modify many regulatory stress signaling pathways in plants. Both nitrate sulfate assimilations must be synchronized with photosynthesis, which ensures energy reductants for these pathways. However, photosynthesis is also a source reactive oxygen species, whose levels are controlled by glutathione other antioxidants. In this study, we investigated the effect supplemental far-red (735 nm) blue (450 lights on diurnal expression genes related to...
The maturity date (MD) of Prunus stone fruit has been long known to be a quantitatively inherited trait. A NAC-type gene indicated as PpNAC1 (ppa008301m) found recently strong candidate major influencing MD in peach. 9-bp insertion this resulted earlier two segregating peach populations. This study was carried out test whether mutation the can used reliable functional marker for wide range cultivars various origins and phenotypic characters. total 125 were examined using 3 × custom...
The influence of different solvents (propylene glycol, glycerol, ethanol), as well technological procedures (melting, rapid and slow cooling), on the formation polymorphous piroxicam modifications was examined in course elaboration a "soft-patch" type semisolid pharmaceutical dosage form. thermodynamical behavior, some physicochemical properties (such melting point, dissolution rate), infrared (IR) spectrum formed (needle cubic) crystal were studied, possibilities their avoidance examined.
Abstract Light‐dependent (250 or 500 µmol/m 2 /s, red/far‐red: 15/1; 250 /s and 10/1) adjustment of glutathione metabolism during cold acclimation (5°C, 7 d) was compared in four wheat genotypes (14‐day‐old) differing freezing tolerance. Only the shoot fresh weight two tolerant increased cold, regardless light conditions. Their electrolyte leakage decreased high intensity. Cold greatly both amount γ‐glutamylcysteine (glutathione precursor) cysteinylglycine (degradation product) all grown...
Hereditary podocytopathies are genetically highly heterogeneous. Extra-renal symptoms, when associated, specific for the causal gene. Two unrelated pedigrees presented with a novel infantile-onset severe disorder characterized by steroid-resistant nephrotic syndrome (SRNS), cataracts, sensorineural deafness and enterocolitis. In first four-generation pedigree (FamA), segregated in an X-linked pattern autosomal recessive mode second (FamB). Since did not correspond to any of known...