A5047887618- Tissue Engineering and Regenerative Medicine
- Muscle Physiology and Disorders
- Telomeres, Telomerase, and Senescence
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
Cincinnati Children's Hospital Medical Center
2019-2022
University of Cincinnati
2022
Abstract Skeletal muscle can repair and regenerate due to resident stem cells known as satellite cells. The muscular dystrophies are progressive wasting diseases underscored by chronic damage that is continually repaired cell-driven regeneration. Here we generate a genetic strategy mediate cell ablation in dystrophic mouse models investigate how impact disease trajectory. Unexpectedly, observe depletion of reduces features, with improved histopathology, enhanced sarcolemmal stability...
Perturbagen analysis of Crohn's disease (CD) ileal gene expression data identified small molecules including eicosatetraynoic acid (ETYA), which may exert an antifibrotic effect. We developed a patient-specific human intestinal organoid (HIO) model system to test molecule regulation mitochondrial and wound-healing functions implicated in stricturing behavior.
Abstract Satellite cells are skeletal muscle resident stem that regenerate adult myofibers following an acute injury to muscle. Despite the assumption loss of satellite would be detrimental in a chronic regeneration-inducing disease such as muscular dystrophy, this has never been tested using mouse genetics. Here we generated novel model cell ablation and crossed it with models dystrophy directly investigate how critical these maintaining during degenerative disorder. deletion 2-week-old...