A5033014771- Vagus Nerve Stimulation Research
- Heart Rate Variability and Autonomic Control
- Renin-Angiotensin System Studies
- Ion Channels and Receptors
- Neuropeptides and Animal Physiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Immune Response and Inflammation
- Eicosanoids and Hypertension Pharmacology
- Nicotinic Acetylcholine Receptors Study
- Blood Pressure and Hypertension Studies
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Advanced Glycation End Products research
- Inflammatory Bowel Disease
- Neuroscience and Neural Engineering
Feinstein Institute for Medical Research
2019-2021
Northwell Health
2019-2021
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2019-2021
Hofstra University
2018-2019
Circulatory Technology (United States)
2014-2018
The axons of the sensory, or afferent, vagus nerve transmit action potentials to central nervous system in response changes body's metabolic and physiological status. Recent advances identifying neural circuits that regulate immune responses infection, inflammation injury have revealed signals release cytokines other factors produced by macrophages. Here we record compound cervical adult mice reveal specific activity occurs following administration proinflammatory tumor necrosis factor (TNF)...
The vagus nerve plays an important role in the regulation of organ function, including reflex pathways that regulate immunity and inflammation. Recent studies using genetically modified mice have improved our understanding molecular mechanisms neural control immunity. However, mapping signals transmitted has been limited by technical challenges. Here, we standardized experimental protocol to record compound action potentials nerve.The was isolated Balb/c B6.129S mice, placed either on a hook...
Inflammatory bowel disease (IBD) is chronic inflammation of the gastrointestinal tract that affects millions people worldwide. Although etiology IBD not clear, it known products from stressed cells and enteric microbes promote intestinal inflammation. High mobility group box 1 (HMGB1), originally identified as a nuclear DNA binding protein, cytokine-like protein mediator implicated in infection, sterile injury, autoimmune disease, IBD. Elevated levels HMGB1 have been detected inflamed human...
Abstract Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosynthetic product ACh at appreciable concentrations to potentially act upon the affect pressure. Recently we discovered a T-cell subset expressing ChAT (T ), whereby genetic ablation of these cells produces hypertension, indicating that production T regulates Accordingly, reasoned...
ABSTRACT Survival of an organism requires mechanisms to sense damaging factors in the environment. In mammals, bacterial toxins and inflammatory mediators stimulate nociceptive sensory neurons activate protective reflexes. Whereas vagus nerve reflex circuit that protects against inflammation, termed “inflammatory reflex,” was described more than twenty years ago 1,2 , how detects inflammation initiate has remained unknown. Here we show transient receptor potential ankyrin 1 (TRPA1) is...
Abstract The vagus nerve plays an important role in maintaining organism’s immune homeostasis through the inflammatory reflex. Inflammatory molecules including LPS, TNF and IL-1β can mediate electrophysiological changes signaling. Reasoning that these signals are mediated though specific neuronal fibers be identified by molecular markers, we administered endotoxin to mice received optovin, a molecule interacts with TRPA1 is light sensitive. Selective stimulation of TRPA1+ significantly...
Despite significant advances in anti-hypertensive therapy, more than half of hypertensive patients fail to control their blood pressure. The estimated morbidity associated with hypertension is over 30% worldwide, and many progressively develop cardiovascular disease chronic kidney disease. Thus, the development novel antihypertensive therapies required. Acetylcholine, released by cholinergic neurons lymphocytes, a major mediator endothelium-dependent, arterial smooth muscle relaxation that...