A5027893900- COVID-19 Clinical Research Studies
- Renin-Angiotensin System Studies
- Cardiac electrophysiology and arrhythmias
- Poisoning and overdose treatments
- Transcranial Magnetic Stimulation Studies
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Lung Cancer Research Studies
- Nicotinic Acetylcholine Receptors Study
- Cancer, Lipids, and Metabolism
- Neuropeptides and Animal Physiology
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Treatments and Mutations
- Bipolar Disorder and Treatment
- Healthcare Decision-Making and Restraints
- SARS-CoV-2 detection and testing
- Genetic Neurodegenerative Diseases
- Respiratory and Cough-Related Research
- Head and Neck Cancer Studies
- Hypothalamic control of reproductive hormones
- Long-Term Effects of COVID-19
- Dermatological and COVID-19 studies
- Lipid metabolism and disorders
Loma Linda University
2020-2023
Loma Linda University Medical Center
2020-2023
Feinstein Institute for Medical Research
2021
Northwell Health
2021
University of Southern California
2012-2017
Yale University
1998
Alder Hey Children's Hospital
1994
University of Liverpool
1994
Inflammation, the body’s primary defensive response system to injury and infection, is triggered by molecular signatures of microbes tissue injury. These molecules also stimulate specialized sensory neurons, termed nociceptors. Activation nociceptors mediates inflammation through antidromic release neuropeptides into infected or injured tissue, producing neurogenic inflammation. Because HMGB1 an important inflammatory mediator that synthesized we reasoned nociceptor might be a component...
Purinergic P2X4 receptors (P2X4Rs) belong to the P2X superfamily of ion channels regulated by ATP. We recently demonstrated that P2X4R knockout (KO) mice exhibited deficits in sensorimotor gating, social interaction, and ethanol drinking behavior. Dopamine (DA) dysfunction may underlie these behavioral changes, but there is no direct evidence for P2X4Rs' role DA neurotransmission. To test this hypothesis, we measured markers function dependent behaviors KO mice. altered density pre-synaptic...
ATP analogues containing a CXY group in place of the α,β-bridging oxygen atom are powerful chemical probes for studying ATP-dependent enzymes. A limitation such has been that conventional synthetic methods generate mixture diastereomers when bridging carbon substitution is nonequivalent (X ≠ Y). We report here novel method based on derivatization bisphosphonate precursor with d-phenylglycine chiral auxiliary enables preparation individual α,β-CHF-ATP and α,β-CHCl-ATP, which differ only...
COVID-19 infection has been found to precipitate hypercoagulability and transiently increase antiphospholipid antibodies. However, it is yet be determined how likely these transient changes contribute thrombotic events syndrome. We present a case in which antibodies were detected the presence of significant thromboses. The patient was subsequently treated for suspected catastrophic syndrome following infection.
Abstract Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosynthetic product ACh at appreciable concentrations to potentially act upon the affect pressure. Recently we discovered a T-cell subset expressing ChAT (T ), whereby genetic ablation of these cells produces hypertension, indicating that production T regulates Accordingly, reasoned...
There are several recent reports of tetrahydrocannabinol vaping-related sudden cardiac arrest, and the mechanisms unclear. We report a unique case 19-year-old female who suffered documented prolonged QTc leading to Torsades de pointes arrest in setting frequent marijuana wax vaping. While she demonstrated normal baseline measurements years earlier, was found have genetic predisposition prolongation (genetic mutation, family history QTc), suggesting that specific patient populations at higher...
Abstract Objective To explore the efficacy of primary chemoradiation with cisplatin versus cetuximab respect to HPV/p16 and smoking statuses. Methods We retrospectively reviewed patients from our center locally advanced non-nasopharyngeal head neck squamous cell carcinoma (HNSCC) who received or between 2006 2018. Results The median OS for (n = 66) was not reached 132 months when treated 55) (p 0.03). For HPV/p16-positive patients, we found 34) 60 21) 0.036). In group, in group 44) 32)...
Background: High-titer convalescent plasma given early for COVID-19 may decrease progression into a severe infection. Here, we reported study of serial antibody measurements in patients who received CP at our center and performed systematic review randomized trials on CP. Methods: Our participated the Mayo Clinic Expanded Access Program Convalescent Plasma. Patients diagnosed with by nasopharyngeal polymerase chain reaction between April August 2020 were included if staffing was available...
Background: Hypertriglyceridemia is a critical risk factor for coronary artery disease. Apolipoprotein C-III (APOC3), produced by liver hepatocytes, regulates triglyceride (TG) levels. We studied effect of novel GalNAc-conjugated APOC3 targeting RNAi trigger (STP125G) on and TG levels in humanized mouse model. Methods: In dose response study, female uPA-SCID mice (n=4 mice/group), group 1 received PBS control, 2 10mg/kg 3 30mg/kg STP125G, subcutaneously day 0. Liver biopsies, plasma serum...
Despite significant advances in anti-hypertensive therapy, more than half of hypertensive patients fail to control their blood pressure. The estimated morbidity associated with hypertension is over 30% worldwide, and many progressively develop cardiovascular disease chronic kidney disease. Thus, the development novel antihypertensive therapies required. Acetylcholine, released by cholinergic neurons lymphocytes, a major mediator endothelium-dependent, arterial smooth muscle relaxation that...
Conference Abstract| December 01 1994 Aminophylline Increases Frusemide Induced Diuresis P Martin; Martin 1Cardiac Intensive Care, Royal Liverpool Children's Hospital, Alder Hey, L12 2AP Search for other works by this author on: This Site PubMed Google Scholar V Shah; Shah AJ Petros Clin Sci (Lond) (1994) 87 (s31): 10P. https://doi.org/10.1042/cs045010Pb_pt2 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share MailTo Twitter LinkedIn Cite Get...