A5042480789- Oral and gingival health research
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Wound Healing and Treatments
- Hippo pathway signaling and YAP/TAZ
- Skin and Cellular Biology Research
- Cancer-related Molecular Pathways
- Developmental Biology and Gene Regulation
- Wnt/β-catenin signaling in development and cancer
- Tumors and Oncological Cases
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Molecular Biology Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glycosylation and Glycoproteins Research
- Hedgehog Signaling Pathway Studies
- Immunotherapy and Immune Responses
- Head and Neck Cancer Studies
- Pluripotent Stem Cells Research
- Ferroptosis and cancer prognosis
- Colorectal and Anal Carcinomas
King's College London
2019-2024
Cell Therapy Catapult
2024
Guy's Hospital
2019-2024
Tata Memorial Hospital
2016-2023
Cell and Gene Therapy Catapult
2023
Advanced Centre for Treatment, Research and Education in Cancer
2016-2023
Homi Bhabha National Institute
2017-2018
Cancer Research Institute
2013
We present an integrative genome-wide analysis that can be used to predict the risk of progression from leukoplakia oral squamous cell carcinoma (OSCC) arising in gingivobuccal complex (GBC). find genomic and transcriptomic profiles resemble those observed later stages OSCC several changes are associated with this progression, including amplification 8q24.3, deletion 8p23.2, dysregulation DERL3, EIF5A2, ECT2, HOXC9, HOXC13, MAL, MFAP5 NELL2. Comparing copy number primary tumors without...
Gingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an aggressive malignancy with high mortality often preceded by premalignant lesions, including leukoplakia. Previous studies have reported genomic drivers in OSCC, but much remains to be elucidated about DNA methylation patterns across different stages of carcinogenesis.There a serious lack biomarkers and clinical application for early detection prognosis gingivobuccal cancers. Hence, search novel biomarkers, we measured...
Dedifferentiation is the process by which terminally differentiated cells acquire properties of stem cells. During mouse skin wound healing, Gata6-lineage positive sebaceous duct are able to dedifferentiate. Here we have integrated lineage tracing and single-cell mRNA sequencing uncover underlying mechanism. negative epidermal in wounds transcriptionally indistinguishable. Furthermore, contrast reprogramming induced pluripotent cells, same genes expressed dedifferentiation differentiation...
Background Keratins are structural marker proteins with tissue specific expression; however, recent reports indicate their involvement in cancer progression. Previous study from our lab revealed deregulation of many genes related to molecular integrity including KRT76. Here we evaluate the role KRT76 downregulation oral precancer and development. Methods We evaluated expression by qRT-PCR normal tumor tissues cavity. also analyzed K76 immunohistochemistry normal, precancerous lesion (OPL),...
Abstract A key feature in the pathogenesis of OSCC is genetic instability, which results altered expression genes located amplified/deleted chromosomal regions. In a previous study we have shown that amplification 11q22.1-q22.2 region, encoding cIAP1 and cIAP2, associated with lymph node metastasis poor clinical outcome OSCC. Here, validate aCGH by nuc ish detect weak at locus 37% 182 samples tested. We find positive correlation metastasis, reduced survival, increased cancer recurrence,...
Inactivating mutations in the EGF-like ligand binding domain of NOTCH1 are a prominent feature mutational landscape oral squamous cell carcinoma (OSCC). In this study, we investigated keratinocyte lines derived from OSCC biopsies that had been subjected to whole exome sequencing. One line, SJG6, was found have truncating both alleles, resulting loss expression. Overexpression intracellular (NICD) SJG6 cells promoted adhesion and differentiation, while suppressing proliferation, migration...
Abstract Oral squamous cell carcinomas (OSCCs) are genetically heterogeneous and exhibit diverse stromal immune microenvironments. Acquired resistance to standard chemo‐, radio‐, targeted therapies remains a major hurdle in planning effective treatment modalities for OSCC patients. Since Caspase 8 (CASP8) is frequently mutated OSCCs, we were interested explore potential interaction between tumour‐infiltrating lymphocytes (TILs) CASP8 activation using high‐content image analysis of human...