A5044013823- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Gene Regulatory Network Analysis
- Microtubule and mitosis dynamics
- Gene expression and cancer classification
- Mosquito-borne diseases and control
- Malaria Research and Control
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- T-cell and B-cell Immunology
- Nonlinear Dynamics and Pattern Formation
- Protein Structure and Dynamics
- Color perception and design
- stochastic dynamics and bifurcation
- Circadian rhythm and melatonin
- Metaheuristic Optimization Algorithms Research
- Pharmacological Effects and Toxicity Studies
- Chemical synthesis and alkaloids
- Machine Learning in Bioinformatics
- Photoreceptor and optogenetics research
- Cholinesterase and Neurodegenerative Diseases
- Pancreatitis Pathology and Treatment
- Advanced Graph Neural Networks
- Synthesis and bioactivity of alkaloids
Directorate of Coldwater Fisheries Research
2025
King's College London
2022-2024
The London College
2024
Gwangju Institute of Science and Technology
2024
Cell and Gene Therapy Catapult
2023
University of Kashmir
2023
Guy's Hospital
2022-2023
Jamia Millia Islamia
2011-2022
University of Wisconsin–Milwaukee
2022
Jawaharlal Nehru University
2015-2018
Zika virus (ZikV) has emerged as a potential threat to human health worldwide. A member of the Flaviviridae, ZikV is transmitted humans by mosquitoes. It related other pathogenic vector-borne flaviviruses including dengue, West Nile and Japanese encephalitis viruses, but produces comparatively mild disease in humans. As result its epidemic outbreak lack medication, there need for improved vaccine/drugs. Computational techniques will provide further information about this virus. Comparative...
Increasing temperature due to global warming in the Himalayan regions has severe implications for survival of aquatic ectotherms. To study thermal acclimation and heat tolerance an endangered fish species, Tor putitora, we examined tissue-specific mRNA expression patterns heat-shock proteins (HSP90β; HSP70, HSP60, HSP47, HSP30, HSP20), warm-temperature (WAP65-1) cyclin-dependent kinase inhibitor 1B (CDKN1B) genes liver, brain, gill, kidney, muscle, gonad tissues at intervals 10, 20, 30 days...
Turner Syndrome (TS) is a condition where several genes are affected but the molecular mechanism remains unknown. Identifying that regulate TS network one of main challenges in understanding its aetiology. Here, we studied regulatory from manually curated reported literature and identified essential proteins involved TS. The power-law distribution analysis showed carries scale-free hierarchical fractal attributes. This organization maintained self-ruled constitution nodes at various levels...
Single-cell RNA sequencing (scRNA-seq) of human skin provides a tool for validating observations from in vitro experimental models. By analyzing published dataset healthy adult epidermis, we confirm that the basal epidermal layer is heterogeneous, and three subpopulations non-dividing cells can be distinguished. We show Delta-like ligand 1 (DLL1) expressed subset previously identified as stem cultured keratinocytes map distribution other Notch ligands receptors to specific cell compartments....
Identification of key regulator/s in ovarian cancer (OC) network is important for potential drug target and prevention from this cancer. This study proposes a method to identify the regulators their importance.The protein-protein interaction (PPI) constructed curated 6 hundred genes standard six databases (some are experimentally verified). We proposed (KRs) complex based on tracing backbone hubs, which participate at all levels organization, characterized by Newmann-Grivan community finding...
Cardiorenal syndromes constellate primary dysfunction of either heart or kidney whereby one organ leads to the another. The role several microRNAs (miRNAs) has been implicated in number diseases, including hypertension, failure, and diseases. Wide range miRNAs identified as ideal candidate biomarkers due their stable expression. Current study was aimed identify crucial target genes associated with cardiorenal syndrome explore interaction analysis. Three differentially expressed (DEMs),...
The breast cancer network constructed from 70 experimentally verified genes is found to follow hierarchical scale free nature with heterogeneous modular organization and diverge leading hubs. topological parameters (degree distributions, clustering co-efficient, connectivity centralities) of this obey fractal rules indicating absence centrality lethality rule, efficient communication among the components. From theoretical approach, we identified few key regulators out large number hubs,...
Dedifferentiation is the process by which terminally differentiated cells acquire properties of stem cells. During mouse skin wound healing, Gata6-lineage positive sebaceous duct are able to dedifferentiate. Here we have integrated lineage tracing and single-cell mRNA sequencing uncover underlying mechanism. negative epidermal in wounds transcriptionally indistinguishable. Furthermore, contrast reprogramming induced pluripotent cells, same genes expressed dedifferentiation differentiation...
Ethyl acetate, chloroform, butanol, and methanol extracts from the aerial part of Peganum harmala were tested for antibacterial, antioxidant, antiviral activities. The antibacterial activity was evaluated by determination minimum inhibitory concentration (MIC) using solid medium technique. Oxacillin, amoxicillin, ticarcillin, cefotaxim, amphotericin used as control agents. against human cytomegalovirus (HCMV) strain AD-169 (ATCC Ref. VR 538) Coxsackie B virus type 3 (CoxB-3) a cytopathic...
In fact, the risk of dying from CVD is significant when compared to developing end-stage renal disease (ESRD). Moreover, patients with severe CKD are often excluded randomized controlled trials, making evidence-based therapy comorbidities like complicated. Thus, goal this study was use an integrated bioinformatics approach not only uncover Differentially Expressed Genes (DEGs), their associated functions, and pathways but also give a glimpse how these two conditions related at molecular...
Abstract The stress driven dynamics of Notch-Wnt-p53 cross-talk is subjected to a few possible dynamical states governed by simple fractal rules, and allowed decide its own fate choosing one these which are contributed from long range correlation with varied fluctuations due active molecular interaction. topological properties the networks corresponding have hierarchical features assortive structure. signal nutlin modulated mediator GSK3 acts as anti-apoptotic in this system, whereas, Axin...
The propagation of Ca2+ wave through gap junction in smooth muscle cell is studied as a function electrical coupling parameter (g) modulated by level the cell. range activation time with amplitude found to increase g, which identified critical activation, T(F) g. Then identical oscillators are allowed interact via and diffusive ions diffused junctions, rate intercellular synchronization among them studied. phase diagrams (T(F) - g) epsilon) spaces separate oscillation death damped...
Hepatitis B virus (HBV) infection is one of the major causes liver diseases, which can lead to hepatocellular carcinoma. The role HBV envelope proteins crucial in viral morphogenesis, infection, and propagation. Thus, blocking pleiotropic functions these especially PreS1 PreS2 domains large surface protein (LHBs) a promising strategy for designing efficient antivirals against infection. Unfortunately, structure LHBs has not been elucidated yet, it seems that any structure-based drug...
Abstract The maintenance of adult tissue homeostasis is dependent on the functional cross-talk between stem cells (SCs) and tissue-resident immune cells. This reciprocal relationship also essential for organogenesis during early life. skin harbors a relatively large population Regulatory T (Tregs) that accumulate within first two weeks after birth. A role seeding Tregs (ETregs) week life currently unexplored. Here, we show are detected as postnatal day 3 (P3) where they localize to hair...
Complex breast cancer network constructed from experimentally verified seventy genes, by coordinating standard seven human protein and genome databases, follows hierarchical scale free features. Centrality based method of identification inferred genes is implemented to this has predicted forty nine nineteen non-breast genes. As predicting good candidate before experimental analysis will save time effort both. Fourteen out are found involve in various types diseases, five engaged non-cancer...