A5019406353- Wound Healing and Treatments
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Hair Growth and Disorders
- Immune Response and Inflammation
- Genetics, Aging, and Longevity in Model Organisms
- Gut microbiota and health
- Lymphatic System and Diseases
- Cell Adhesion Molecules Research
- Exercise and Physiological Responses
- Developmental Biology and Gene Regulation
- melanin and skin pigmentation
- IL-33, ST2, and ILC Pathways
- Tryptophan and brain disorders
- Hippo pathway signaling and YAP/TAZ
- Pluripotent Stem Cells Research
- Cellular Mechanics and Interactions
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Stress Responses and Cortisol
- Atherosclerosis and Cardiovascular Diseases
The London College
2024
King's College London
2019-2024
Gwangju Institute of Science and Technology
2024
Cell and Gene Therapy Catapult
2024
Guy's Hospital
2019-2021
Cell Therapy Catapult
2019
Birkbeck, University of London
2017
University College London
2017
Institute of Structural and Molecular Biology
2017
Fluoropyrimidines are the first-line treatment for colorectal cancer, but their efficacy is highly variable between patients. We queried whether gut microbes, a known source of inter-individual variability, impacted drug efficacy. Combining two tractable genetic models, bacterium E. coli and nematode C. elegans, we performed three-way high-throughput screens that unraveled complexity underlying host-microbe-drug interactions. report microbes can bolster or suppress effects fluoropyrimidines...
Solar ultraviolet radiation (UVR) is a major source of skin damage, resulting in inflammation, premature ageing, and cancer. While several UVR-induced changes, including extracellular matrix reorganisation epidermal DNA have been documented, the role different fibroblast lineages their communication with immune cells has not explored. We show that acute chronic UVR exposure led to selective loss fibroblasts from upper dermis human mouse skin. Lineage tracing vivo live imaging revealed repair...
Skin immune homeostasis is a multi-faceted process where dermal dendritic cells (DDCs) are key in orchestrating responses to environmental stressors. We have previously identified CD141
Abstract The maintenance of adult tissue homeostasis is dependent on the functional cross-talk between stem cells (SCs) and tissue-resident immune cells. This reciprocal relationship also essential for organogenesis during early life. skin harbors a relatively large population Regulatory T (Tregs) that accumulate within first two weeks after birth. A role seeding Tregs (ETregs) week life currently unexplored. Here, we show are detected as postnatal day 3 (P3) where they localize to hair...
ABSTRACT The tumour-draining lymph nodes (tdLNs) are crucial sites for early immune surveillance of tumours. During tumour development, tdLNs undergo significant stromal remodelling that impacts node (LN) architecture. reconstruction is dependent on the crosstalk between regulatory T cells (Tregs) and resident cells. Notch ligand Jagged1 (Jag1), highly expressed in skin Tregs, critical facilitating stem cell-mediated tissue regeneration. However, role Jag1 pos Tregs mediating activity...
ABSTRACT Skin-resident regulatory T cells (Tregs) play an irreplaceable role in orchestrating cutaneous immune homeostasis and repair, including the promotion of hair regeneration via Notch signaling ligand Jagged-1 (Jag1). While skin Tregs are indispensable for facilitating tissue repair post-wounding, it remains unknown if Jag1-expressing impact wound healing. Using a tamoxifen inducible Foxp3 creERT2 Jag1 fl/fl model, we show that loss functional significantly delays rate full-thickness...
<title>Abstract</title> Skin-resident regulatory T cells (Tregs) play an irreplaceable role in orchestrating cutaneous immune homeostasis and repair, including the promotion of hair regeneration via Notch signaling ligand Jagged-1 (Jag1). While skin Tregs are indispensable for facilitating tissue repair post-wounding, it remains unknown if Jag1-expressing impact wound healing. Using a tamoxifen inducible Foxp3creERT2Jag1fl/fl model, we show that loss functional Jag1 significantly delays rate...
Abstract The maintenance of adult tissue homeostasis is dependent on the functional cross-talk between stem cells (SCs) and tissue-resident immune cells. This reciprocal relationship also essential for organogenesis during early life. skin harbors a relatively large population Regulatory T (Tregs) that accumulate within first two weeks after birth. A role seeding Tregs (ETregs) week life currently unexplored. Here, we show are detected as postnatal day 3 (P3) where they localize to hair...
Abstract Solar ultraviolet radiation (UVR) is a major source of skin damage, resulting in inflammation, premature ageing and cancer. While several UVR-induced changes, including extracellular matrix reorganisation epidermal DNA have been documented, the role different fibroblast lineages their communication with immune cells has not explored. We show that acute chronic UVR exposure led to selective loss fibroblasts from upper dermis human mouse skin. Lineage tracing vivo live imaging...