A5084783539- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Congenital heart defects research
- Mitochondrial Function and Pathology
- Transplantation: Methods and Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Heart Failure Treatment and Management
- Amyotrophic Lateral Sclerosis Research
- Cholinesterase and Neurodegenerative Diseases
- Cardiomyopathy and Myosin Studies
University of Colorado Anschutz Medical Campus
2022-2025
University of Colorado Denver
2022
University of Denver
2020
Background: While operative and perioperative care continues to improve for single ventricle congenital heart disease (SV), long-term morbidities mortality remain high. Importantly, phosphodiesterase-5 inhibitor therapies (PDE5i) are increasingly used, however, little is known regarding the direct myocardial effects of PDE5i therapy in SV population. Objectives: Our group has previously demonstrated that failing myocardium characterized by increased PDE5 activity impaired mitochondrial...
Amyotrophic lateral sclerosis (ALS) is a devastating disorder characterized by motor neuron apoptosis and subsequent skeletal muscle atrophy caused oxidative nitrosative stress, mitochondrial dysfunction, neuroinflammation. Anthocyanins are polyphenolic compounds found in berries that possess neuroprotective anti-inflammatory properties. Protocatechuic acid (PCA) phenolic metabolite of the parent anthocyanin, kuromanin, blackberries bilberries. We explored therapeutic effects PCA transgenic...
The mechanisms responsible for heart failure in single-ventricle congenital disease are unknown. Using explanted tissue, we showed that failing hearts have dysregulated metabolic pathways, impaired mitochondrial function, decreased activity of carnitine palmitoyltransferase activity, and altered functioning the tricarboxylic acid cycle. Interestingly, nonfailing demonstrated an intermediate phenotype suggesting they vulnerable to development future. Mitochondrial targeted therapies...
There are growing numbers of infants and children living with single-ventricle congenital heart disease (SV). However, cardiac dysfunction and, ultimately, failure (HF) common in the SV population ability to predict progression HF patients has been limited, primarily due an incomplete understanding pathogenesis. Here, we tested hypothesis that non-invasive circulating metabolomic profiles can serve as novel biomarkers population. We performed systematic pathway analyses on a subset pediatric...
Objectives: Here, we test the hypothesis that metabolic remodeling represents a pathophysiologic mechanism of heart failure progression in single ventricle congenital disease (SV). Background: SV encompasses group severe cardiac abnormalities where improper development results only one functional pumping chamber. From molecular standpoint, how myocardium adapts to chronic altered hemodynamic conditions physiology, and mechanisms implicated transition failure, which is common population, are...
Significant surgical and medical advances over the past several decades have resulted in a growing number of infants children surviving with hypoplastic left heart syndrome (HLHS) other congenital defects associated single systemic right ventricle (RV). However, cardiac dysfunction ultimately failure (HF) remain most common cause death indication for transplantation this population. Moreover, while early recognition treatment ventricle-related complications are essential to improving...
Introduction: Single Ventricle congenital heart disease (SV) encompasses a group of cardiac abnormalities where improper development the results in only one functional pumping chamber. From molecular standpoint, how myocardium adapts to chronic altered hemodynamic conditions SV physiology, and mechanisms implicated transition failure (HF) which is common population, are poorly understood. Here, we test hypothesis that metabolic remodeling represents pathophysiologic mechanism progression SV....