A5070117385- Anesthesia and Sedative Agents
- Epilepsy research and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Pain Management
- Analytical Methods in Pharmaceuticals
- Pharmacological Effects and Toxicity Studies
- Lysosomal Storage Disorders Research
- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Blood Pressure and Hypertension Studies
- Glycogen Storage Diseases and Myoclonus
- Drug Transport and Resistance Mechanisms
- Nausea and vomiting management
- Carbohydrate Chemistry and Synthesis
- Intensive Care Unit Cognitive Disorders
- Heart Failure Treatment and Management
- Analytical Chemistry and Sensors
- Cholinesterase and Neurodegenerative Diseases
- Analytical Chemistry and Chromatography
- Parasitic Diseases Research and Treatment
- Gastrointestinal motility and disorders
- Advanced Glycation End Products research
- Statistical Methods in Clinical Trials
- Helminth infection and control
- Acute Kidney Injury Research
American College of Clinical Pharmacy
2022
University of Florida
2020
Columbus Oncology and Hematology Associates
2020
vTv Therapeutics (United States)
2019
Cornell University
1996-2018
Union University
2018
University of North Carolina at Chapel Hill
2018
Tris Pharma (United States)
2017
Novartis (United States)
2017
Pfizer (United States)
2016
Caly et al.1 reported that ivermectin inhibited severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in vitro for up to 48 hours using at 5 μM. The concentration resulting 50% inhibition (IC50 ; µM) was > 35× higher than the maximum plasma (Cmax ) after oral administration of approved dose when given fasted. Simulations were conducted an available population pharmacokinetic model predict total (bound and unbound) unbound concentration-time profiles a single repeat fasted (200 μg/kg),...
To evaluate factors affecting variability in response to remimazolam general anesthesia. Plasma concentration-time data from 11 Phase 1–3 clinical trials were pooled for the population pharmacokinetic (popPK) analysis and concentration-bispectral index (BIS) 8 popPK-PD analysis. A 3-compartment model with allometric exponents on clearance volume described concentrations over time. An effect compartment an inhibitory sigmoid Emax was fit concentration-BIS data. Simulations performed assess...
Abstract Remimazolam is an ultra‐short‐acting benzodiazepine being investigated for induction and maintenance of general anesthesia procedural sedation. This dose‐response analysis 4 phase 2‐3 studies evaluated covariates that may impact the pharmacodynamic profile (based on theoretical pharmacokinetic principles) require dose adjustments in subpopulations, particularly elderly, if remimazolam has cumulative properties. Covariates affecting time to loss consciousness extubation were using...
Abstract Introduction Caly, Druce (1) reported that ivermectin inhibited SARS-CoV-2 in vitr o for up to 48 h using at 5μM. The concentration resulting 50% inhibition (IC 50, 2 µM) was >35x higher than the maximum plasma (Cmax) after oral administration of approved dose when given fasted. Method Simulations were conducted an available population pharmacokinetic model predict total (bound and unbound) unbound concentration-time profiles a single repeat fasted (200 μg/kg), 60 mg, 120 mg....
The use of pharmacogenetics and pharmacogenomics in the drug development process, assessment such data submitted to regulatory agencies by industry, has generated significant enthusiasm as well important reservations within scientific medical communities. This situation arisen because increasing number exploratory confirmatory investigations into variations RNA expression patterns DNA sequences being conducted preclinical clinical phases development, uncertainty surrounding acceptance these...
Mivacurium consists of a mixture three stereoisomers: cis-trans (34-40%), trans-trans (52-60%), and cis-cis (4-8%). These isomers differ in potency (the the are equipotent isomer is 1/13th as potent neuromuscular blocking agent) rates vitro hydrolysis (in half-lives less than 2 min for 276 isomer). The current study was undertaken to determine pharmacokinetic profile individual stereoisomers mivacurium, evaluate dose-proportionality more isomers, pharmacodynamics mivacurium healthy adult...
Cisatracurium, one of 10 isomers atracurium, undergoes pH and temperature-dependent Hofmann elimination in plasma tissues. The clearance cisatracurium due to organ was estimated by applying a nontraditional two-compartment pharmacokinetic model with occurring from both compartments concentration-time data 31 healthy adult surgical patients normal renal hepatic function. rate constant the central compartment, intercompartmental constants, volume compartment were obtained fit. peripheral could...
Cisatracurium, one of 10 isomers atracurium, undergoes pH and temperature-dependent Hofmann elimination in plasma tissues. The clearance cisatracurium due to organ was estimated by applying a nontraditional two-compartment pharmacokinetic model with occurring from both compartments concentration-time data 31 healthy adult surgical patients normal renal hepatic function. rate constant the central compartment, intercompartmental constants, volume compartment were obtained fit. peripheral could...
Cisatracurium, one of the ten isomers in atracurium, is a nondepolarizing muscle relaxant with an intermediate duration action. It more potent and less likely to release histamine than atracurium. As composing it presumably undergoes Hofmann elimination. This study was conducted describe pharmacokinetics cisatracurium its metabolites determine dose proportionality after administration 2 or 4 times ED(95).Twenty ASA physical status 1 patients undergoing elective surgery under nitrous...
The delta opioid receptor (DOR) has been identified as a therapeutic target for migraine, with DOR agonists exhibiting low abuse potential compared conventional µ-opioid agonists. TRV250 is novel small molecule agonist of the that preferentially selective G-protein signaling, relatively little activation β-arrestin2 post-receptor signaling pathway. This selectivity provides reduced susceptibility to proconvulsant activity seen non-selective significantly nitroglycerin-evoked hyperalgesia in...
Remimazolam is an ultra-short acting benzodiazepine under development for procedural sedation and general anesthesia. Population pharmacokinetic analysis (PopPK) was conducted remimazolam with arterial venous samples previously, but results were limited by arterial-venous concentration differences inaccurate central volume of distribution (V1) estimates. A new model developed to describe covariate effects after accounting differences. Arterial plasma concentration-time data from 11 clinical...
The clinical effects of remimazolam (an investigational, ultra-short acting benzodiazepine being studied in procedural sedation) were measured using the Modified Observer's Assessment Awareness/Sedation Scale (MOAA/S). objective this analysis was to develop a population pharmacokinetic/pharmacodynamic model describe remimazolam-induced sedation with fentanyl over time sedation. MOAA/S from 10 phase I-III trials pooled for analysis, where data collected after administration placebo or without...
Mazindol is under investigation for the treatment of attention-deficit/hyperactivity disorder (ADHD) because its alertness-enhancing properties. A novel controlled-release (CR) formulation mazindol was developed to allow once-daily dosing. The aim this study evaluate efficacy CR in adults with ADHD. We conducted a randomized, double-blind, placebo-controlled 6-week trial. Subjects diagnosed ADHD using Mini-International Neuropsychiatric Structured Interview (MINI) and an Rating Scale,...
The impact of inflammation on variability in the pharmacokinetics (PK) and pharmacodynamics (PD) drugs should be considered design, analysis, interpretation clinical pharmacology studies. Data suggest that metabolism transport drugs, as well expression receptors, may change presence inflammation. implications these changes are not straightforward; they vary depending whether is active or controlled with time successful treatment
Azithromycin (AZI), a broad-spectrum antibiotic, accumulates in polymorphonuclear cells and peripheral blood mononuclear cells. The distribution of AZI proinflammatory may be important to the anti-inflammatory properties. Previous studies have described plasma pharmacokinetics. objective this study was describe pharmacokinetics whole (concentration [Cb]) [Cp]) healthy subjects. In study, 12 subjects received (500 mg once day for 3 days). Cb Cp were quantified serial samples collected up...
In a double‐Wind, randomized, placebo‐controlled study, the pharmacokinetics of alprazolam and its active metabolite, α‐hydroxyalprazolam, were determined in 12 normal subjects dialysis patients [ 7 hemodialysis (HD) 5 continuous ambulatory peritoneal (CAPD) ]. Blood samples collected over 48 hours after 0.5 mg 2 administration. Alprazolam α‐hydroxyalprazolam concentrations free fraction determined. The similar HD with exception higher patients. Differences detected, however, CAPD when...