A5110941339- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Immune Cell Function and Interaction
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Prenatal Screening and Diagnostics
- IL-33, ST2, and ILC Pathways
- Gallbladder and Bile Duct Disorders
- Eosinophilic Esophagitis
- Ethics in Clinical Research
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
- Microtubule and mitosis dynamics
- Immunotherapy and Immune Responses
- Pancreatitis Pathology and Treatment
- COVID-19 and healthcare impacts
- Molecular Biology Techniques and Applications
- Aortic Thrombus and Embolism
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiac tumors and thrombi
- Photoreceptor and optogenetics research
- Global Maternal and Child Health
- Eosinophilic Disorders and Syndromes
- Cannabis and Cannabinoid Research
- MicroRNA in disease regulation
Medical College of Wisconsin
2019-2025
Woman's Hospital
2023
Northeast Georgia Medical Center
2022-2023
University of Wisconsin–Madison
2021
Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation. While T cells inflammatory cytokines play role in this process, the precise interplay between adaptive innate arms system that propagates inflammation central nervous remains incompletely understood. Using murine model GVHD, we...
Gastrointestinal (GI) tract graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation and attributable to dysregulation that occurs between the effector regulatory arms of immune system. Whereas T cells have primary role in counterbalancing GVHD-induced inflammation, identifying harnessing other pathways promote tolerance remain goals this disease. Herein, we identified interleukin-34 (IL-34) as an intestinal epithelium–derived cytokine...
Abstract Rho GTPases form plasma membrane-associated patterns that control the cytoskeleton during cell division, morphogenesis, migration, and wound repair. Their patterning involves transitions between inactive cytosolic active membrane-bound states, regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), dissociation inhibitors (GDIs). However, relationships these role of different regulators remain unclear. We developed a novel reconstitution approach...
Paneth cell metaplasia (PCM) typically arises in pre-existing gastrointestinal (GI) diseases; however, the mechanistic pathway that induces and whether PCM is initiated exclusively by disorders intrinsic to GI tract not well known. Here, we describe development of a murine model chronic myelogenous leukemia (CML) driven an inducible bcr-abl oncogene. Mechanistically, CML proinflammatory state within results production epithelial-derived IL-33. The binding IL-33 decoy receptor ST2 leads IL-9...
Rho GTPases such as Rho, Rac, and Cdc42 are important regulators of the cortical cytoskeleton in processes including cell division, locomotion, repair. In these processes, assume characteristic patterns wherein active occupy mutually exclusive "zones" cortex. During wound repair, for example, a zone encircles edge is turn encircled by zone. Here we evaluated contributions cross-talk between to patterning their respective zones wounded Xenopus oocytes using experimental manipulations...
Excerpt Cholesterol pericarditis is a very rare disease and, at present, poorly understood. Reports of only 11 cases have appeared in the world literature, four them American medical journals.1, 2, 3, 9 The first reported autopsy was done on one latter cases. present case twelfth reported, and second this country which an performed. It therefore understandable that time far from being well known, especially standpoint pathogenesis. This will be discussed more detail later paper. CASE REPORT
Abstract Early innate education of hematopoietic progenitors within the bone marrow (BM) stably primes them for either trained immunity or instead immunoregulatory functions. We herein demonstrate that in vivo vitro activation BM via Toll-like receptor-9 generates a population plasmacytoid dendritic cell (pDC) precursors (CpG-pre-pDCs) that, unlike pDC isolated from PBS-incubated (PBS-pre-pDCs), are endowed with capacity to halt progression ongoing experimental autoimmune encephalomyelitis....
INTRODUCTION: The same factors contributing to disproportionately worse health outcomes are also barriers inclusion in research for Black, Hispanic, and Indigenous patients. In this subanalysis of a large, multisite prospective cohort study maternal plasma mRNA signatures adverse pregnancy (APOs), we sought determine whether equitable representation was aided by the large community hospital as an enrollment site. METHODS: Pregnant persons between 18 45 year old with singleton eligible enroll...
INTRODUCTION: This study sought to determine whether a decentralized, mobile-friendly, virtual model could achieve appropriate enrollment for pregnancy health after COVID-19 closed most clinical research. Preterm birth continues be significant and growing issue with 2021 rates exceeding 10%. There is urgent need new research technology improve the ability predict, prevent, personalize treatment complications such as preterm birth, preeclampsia, gestational diabetes. METHODS: was prospective,...
Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation. While T cells inflammatory cytokines play role in this process, the precise interplay between adaptive innate arms system that propagates inflammation central nervous remains incompletely understood. Using murine model GVHD, we...
Introduction: Lemmel's syndrome is a rare condition that results in obstructive jaundice, most commonly from periampullary duodenal diverticulum. They typically cause the sphincter of Oddi to malfunction or manually impede common bile duct's (CBD) outflow. It crucial have high index suspicion establish correct diagnosis, as this can imitate several benign and malignant abnormalities region. We report preeminent case Lemmel’s successfully treated with ERCP. Case Description/Methods: A...
ABSTRACT Paneth cell metaplasia (PCM) typically arises in the setting of pre-existing gastrointestinal (GI) diseases; however, mechanistic pathway that induces and whether PCM is initiated exclusively by disorders intrinsic to GI tract has not been delineated. Herein, we describe development a murine model inducible bcr/abl oncogene-driven chronic myelogenous leukemia (CML) which causally temporally linked leukemia. Mechanistically, CML induced proinflammatory state within resulted...
Acute cholangitis is a biliary tract infection secondary to the obstruction, which causes stasis and bacterial overgrowth. Typically, it presents with Charcot triad of right upper quadrant abdominal pain, jaundice, fever. Most acute cases are choledocholithiasis. There rare resulting from pancreatic neoplasm. We report case 43-year-old Caucasian male who was found unresponsive at home hypotension, anemia, severe jaundice. Initial imaging studies were notable for periampullary mass lesion...