A5054283494- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Global Health and Surgery
- Advanced MRI Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Craniofacial Disorders and Treatments
- Ophthalmology and Eye Disorders
- Cerebrospinal fluid and hydrocephalus
- Spinal Fractures and Fixation Techniques
- Neuroscience and Neuropharmacology Research
- Organ Donation and Transplantation
- Management of metastatic bone disease
- Bone Tumor Diagnosis and Treatments
- MRI in cancer diagnosis
- Innovations in Medical Education
- Radiomics and Machine Learning in Medical Imaging
- Epilepsy research and treatment
- Cancer-related cognitive impairment studies
- Facial Trauma and Fracture Management
Uppsala University
2015-2025
Uppsala University Hospital
2009-2023
CHI St. Vincent
2013-2015
Arkansas Biosciences Institute
2014
University of Oxford
2008
Here, we report a case of COVID-19–related acute necrotizing encephalopathy where SARS-CoV-2 RNA was found in CSF 19 days after symptom onset testing negative twice. Although monocytes and protein levels were only marginally increased, our patient never experienced hyperinflammatory state, her neurologic function deteriorated into coma. MRI the brain showed pathologic signal symmetrically central thalami, subinsular regions, medial temporal lobes, stem. Extremely high concentrations neuronal...
Background and Purpose— It is often thought that elderly patients in particular would benefit from endovascular aneurysm treatment. The aim of this analysis was therefore to compare the efficacy safety coiling (EVT) with neurosurgical clipping (NST) subgroup SAH International Subarachnoid Aneurysm Trial (ISAT). Methods— In ISAT cohort 278 patients, 65 years or older, were enrolled. randomly allocated EVT (n=138) NST (n=140). primary outcome proportion a modified Rankin scale score 0 2...
To study the occurrence of secondary insults during neurointensive care patients with subarachnoid hemorrhage using a computerized multimodality monitoring system and to impact on clinical deterioration functional outcome. Patients who were admitted unit between January 1999 December 2002 at least 120 hours data within first 240 included. Data continuously recorded for intracranial pressure (ICP), cerebral perfusion (CPP), mean arterial blood pressure, systolic oxygen saturation,...
Astrocytic glutamate (Glt) uptake keeps brain interstitial Glt levels low. Within the astrocytes is converted to glutamine (Gln), which released and reconverted in neurons. The Glt-Gln cycle energy demanding impaired metabolism has been suggested cause low Gln/Glt ratios. Using microdialysis (MD) measurements from visually noninjured cortex 33 neurointensive care patients with subarachnoid hemorrhage, we have determined how Gln, as a reflection of turnover, relate perturbed metabolism. A...
Since the introduction of molecular definition oligodendrogliomas based on isocitrate dehydrogenase (IDH)-status and 1p19q-codeletion, it has become increasingly evident how this glioma entity differs much from other diffuse lower grade gliomas stands out with longer survival often better responsiveness to adjuvant therapy. Therefore, apart using a oligodendroglioma definition, an extended follow-up time is necessary understand nature slow growing, yet malignant condition. The aim study was...
Olfaction is in many ways the least understood sensory modality. Its organization and connectivity are still under debate. The aim of this study was to investigate anatomy olfactory system by using a cadaver fiber dissection technique vivo tractography attain deeper understanding subcortical organization. Ten cerebral hemispheres were used for white matter according Klingler's technique. Measurements different cortical structures interhemispheric symmetry compared. Diffusion tensor imaging...
BACKGROUND: Subarachnoid hemorrhage (SAH) from a ruptured intracranial aneurysm is devastating disease with high mortality and morbidity. The incidence of SAH increases advancing age. OBJECTIVE: To determine whether age an independent predictor angiographic vasospasm, delayed ischemic neurological deficits (DINDs), or abnormal transcranial Doppler (TCD) measurements in patients aneurysmal subarachnoid hemorrhage. METHODS: Data CONSCIOUS-1 (Clazosentan to Overcome Neurological Ischemia...
The middle longitudinal fascicle (MdLF) is a long, associative white matter tract connecting the superior temporal gyrus (STG) with parietal and occipital lobe. Previous studies show different cortical terminations, possible segmentation pattern of tract. In this study, we performed post-mortem dissection 12 human hemispheres an in vivo deterministic fiber tracking 24 subjects acquired from Human Connectome Project to establish whether constant organization fibers exists among MdLF...
Diffuse low-grade gliomas (DLGG) display different preferential locations in eloquent and secondary associative brain areas. The reason for this tendency is still unknown. We hypothesized that the intrinsic architecture water diffusion properties of white matter bundles these regions may facilitate infiltration. Magnetic resonance imaging sixty-seven diffuse patients were normalized to/and segmented MNI space to create three probabilistic infiltration weighted gradient maps according...
In this study we present the population-based patient material with spontaneous SAH, treated in our Neurosurgical unit during 10 years (1997-2006) after introduction of endovascular treatment aneurysms (EVT) hospital. All patients that had a SAH and potential to survive were admitted. The comprises 1471 patients. 72 % one or more aneurysms. AVM other vascular pathological findings where found 2%. Angiography was judged as normal 21% not performed 5%. 664 by means, 333 operated 31 both...
The transcavernous approach adds a significant exposure advantage in basilar aneurysm surgery. However, one of its frequently reported side effects is postoperative oculomotor nerve palsy.To present the technique mobilizing throughout intracranial course and to analyze consequences on tension clinical outcome.The mobilized from mesencephalic origin superior orbital fissure. Its degree mobility, related imposed pulling force, was measured 11 cadaveric nerves. Tension mathematically deduced...
The clinical evidences of variable epileptic propagation in occipital lobe epilepsy (OLE) have been demonstrated by several studies. However the exact localization focus sometimes represents a problem because rapid to frontal, parietal, or temporal regions. Each white matter pathway close supposed initial can lead towards specific direction, explaining semiology these rare syndromes. Some new insights anatomy are herein described means dissection and compared classical patterns, mostly based...
Standard radiological/topographical classifications of gliomas often do not reflect the real extension tumor within lobar-cortical anatomy. Furthermore, these systems provide information on relationship between growth and subcortical white matter architecture. We propose use an anatomically standardized grid system (the Brain-Grid) to merge serial morphological magnetic resonance imaging (MRI) scans with a representative tractographic atlas. Two illustrative cases are presented show...
Abstract Background Low‐grade gliomas (LGGs) are primary diffuse slow‐growing brain tumors derived from glial cells. The management of these is dependent on their location, which often harbors eloquent areas. We retrospectively recorded the location to identify whether specific differences exist between histological types. Methods analyzed 102 patients with previous diagnosis WHO‐II astrocytomas (62) and oligodendrogliomas (40) according WHO‐2016 classification. MRI sequences (T2‐FLAIR) were...
Intraosseous meningioma of the chordoid type is a rare clinical entity. Radical surgical removal and subsequent cranioplasty treatment choice. Here, authors report severe case involving more than 70% calvarial surface area, which was removed repaired using prefabricated custom-made, titanium-reinforced, bioceramic implant bone-cutting guides. Tumor good esthetic outcome were achieved, along with 17.1% increase intracranial volume. Bioceramic implants have shown promising initial results may...
When diffuse gliomas (DG) affect the brain’s potential to reorganize functional networks, patients can exhibit seizures and/or language/cognitive impairment. The tumor–brain interaction and individual connectomic organization cannot be predicted preoperatively. We aimed to, first, investigate relationship between preoperative assessment intraoperative findings of eloquent tumors in 36 DG operated with awake surgery. Second, we also studied possible mechanisms tumor-induced brain...
We evaluated salient initiatives invested in global neurosurgery over a 60-year period.What are the Phases, Achievements, Challenges, and Lessons of Global Neurosurgery.A retrospective study from 1960 to 2020 analyzing major phases, lessons, progress notes. reviewed foundational need questions innovated tools used answer them.Three phases defining our period were identified. In early phase, birthing academic units onset individual volunteerism dominant concepts. The 2nd phase is summarized...
Abstract Background The focus of clinical management and research in gliomas has been on survival, but the interest treatment effects cognition health-related quality life (HRQoL) is emerging. primary aim this study was to investigate dynamics after brain tumor surgery for astrocytomas oligodendrogliomas grade 2 3. secondary association postoperative changes with HRQoL. Methods In observational study, 48 patients operated an astrocytoma or oligodendrogliomas, 3, at Department Neurosurgery,...