Osteoporotic vertebral compression fractures (OVCFs) can be painful. Percutaneous kyphoplasty (PKP) aims at strengthening the vertebra and reducing pain, but efficacy vary among patients. The purpose of this study was to establish a risk prediction model for pain relief following PKP in patients with OVCF. This retrospective included 208 (training set) 54 (validation OVCF who underwent bone cement treatment between January 2018 October 2023. Based on postoperative VAS scores, were divided...

Antibody-drug conjugates (ADCs) combine the specificity of monoclonal antibodies with potency highly cytotoxic drugs and are known as panaceas, completely changing treatment paradigm for solid tumors. Compared other anti-cancer drugs, do they have better efficacy lower toxicity risks? It is necessary to summarize analyze published clinical research data in this area provide additional evidence-based evidence practice. To comprehensively assess overview safety antibody-drug An umbrella review...

To evaluate the efficacy and safety of siRNA drugs that lower Lp(a) in patients with dyslipidaemia. A network meta-analysis systematic review were conducted to compare targeting Lp(a), based on relevant randomized controlled trials (RCTs). comprehensive search was performed PubMed, Embase, Web Science Cochrane Library (up October 24, 2024). RCTs an intervention duration at least 12 weeks included. Eligible studies compared reduce including both Lp(a)-targeted non-targeted agents, placebo or...

Abstract Objectives Acute pancreatitis (AP) is an inflammatory disease of the pancreas, and prognosis severe AP (SAP) poor. The study aimed to identify promising biomarkers for predicting occurrence survival outcome SAP patients. Materials Methods Two hundred forty patients were retrospectively recruited, in which 72 cases with SAP. Blood test was done collection laboratory indicators. After treatment, mortality recorded. Results Patients group had higher intensive care unit admissions...

In recent years, colchicine has been used to reduce the risk of cardiovascular events; in particular, it effectively for treatment atrial fibrillation (AF). We first discovered that can treat AF a rat model and reverse effects fibrosis. To illustrate potential therapeutic mechanism against AF, we performed comparative transcriptome analyses; our aim was elucidate so as improve prognoses AF. Genomics bioinformatics analyses revealed IL-17 signaling pathway, renin secretion pathway are...

In order to explore the possible mechanism of curcumin in treatment AF, we focused on myocardial fibrosis pathogenesis atrial fibrillation whether could play a role AF by reducing fibrosis.Rats were given daily gavage saline (control and groups) or (4 mL/kg, concentration: 50 mg/mL, during days 4–28. The rat model was induced Ach - CaCl2, evaluate therapeutic effect duration rhythm, degree secretion inflammatory factors serum. RNA-seq alleviating AF. significantly inhibits reduces left...

Although many research have found that colchicine has general therapeutic effect in cardiovascular disease, the mechanism atrial fibrillation not been clearly studied. To explore whether plays a role treatment of AF by reducing myocardial fibrosis, we performed series studies. Rat models were induced Ach-CaCl2 to assess at doses 0.8 mg/kg on duration rhythm, degree and secretion inflammatory factors serum. RNA-Seq was also elucidate possible mechanisms which might reduce alleviation fibrosis...

The ideal alternative for tricuspid valve replacement (TVR) in patients with severe isolated regurgitation remains unclear. aim of the present study was to retrospectively investigate outcomes using bioprosthetic and mechanical valves at position.A total 98 consecutive without left-side cardiac disease or history heart surgery who underwent first-time TVR between January 2010 March 2017 West China Hospital, were included study. Patient data, including all-cause death need reoperation as main...

Background Whether the high cost of cancer drugs is commensurate with their value to patients, which has become focus public concern. We aimed assess new approved for solid in China and explore association between price drugs. Methods identified all tumor that by China's National Medical Products Administration (NMPA) 2016 2020. The these was assessed according American Society Clinical Oncology Value Framework (ASCO-VF) European Magnitude Benefit Scale (ESMO-MCBS). calculated Cohen's κ...

Abstract A 68‐year‐old male patient was admitted for extremities edema and diagnosed with infective endocarditis (IEIE). The underwent mitral aortic valve mechanical replacement due to rheumatic heart disease 26 years ago. He bioprosthetic tricuspid dysfunction severe regurgitation 1 year Two months ago, the emergency permanent pacemaker implantation syncope caused by a third‐degree atrioventricular block. fever worsening dyspnea h Transthoracic echocardiography revealed prosthetic...

Cardiac mass is very rare.We reported a case of cardiac complicated with chronic thromboembolic pulmonary hypertension.

Abstract Background Prosthetic valve detachment is not rare after aortic replacement in Behcet’s disease. However, destruction of the intervalvular fibrous body (IFB) due to disease was rarely reported. Case presentation We report a case 30 year-old woman, with and IFB separation. The patient received three months ago. Her medical history included recurrent oral ulcers cutaneous lesions. Finally, reoperation performed peri-operative steroid therapy carried out. Conclusions presented complication