A5016337222- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Metabolism and Genetic Disorders
- Hydrogen's biological and therapeutic effects
- Sirtuins and Resveratrol in Medicine
- Chronic Myeloid Leukemia Treatments
- ATP Synthase and ATPases Research
- Neuroblastoma Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
- Chemotherapy-induced organ toxicity mitigation
- Epigenetics and DNA Methylation
- Metal complexes synthesis and properties
- Drug Transport and Resistance Mechanisms
Lomonosov Moscow State University
2020-2024
Engelhardt Institute of Molecular Biology
2023-2024
The development of resistance to chemotherapy is one the main problems for effective cancer treatment. Drug may result from disturbances in two important physiological processes-cell proliferation and cell death. Importantly, both processes characterize alterations metabolism, level which often measured using MTT/MTS assays. To examine chemotherapy, different lines are usually used vitro modulation developing resistance. However, after creation resistant lines, researchers have difficulty...
Targeting mitochondria with thenoyltrifluoroacetone (TTFA), an inhibitor of Complex II in the respiratory chain, stimulated cisplatin-induced apoptosis various cell lines normoxia but not hypoxia. This can be explained by elimination involved triggering apoptotic death mitophagy, either Parkin-dependent or receptor-mediated. Treatment TTFA alone combination cisplatin did cause accumulation PINK1, meaning that under hypoxic conditions cells survive through activation a receptor-mediated...
Abstract The development of drug resistance reduces the efficacy cancer therapy. Tumor cells can acquire to MDM2 inhibitors, which are currently under clinical evaluation. We generated RG7388-resistant neuroblastoma cells, became more proliferative and metabolically active were less sensitive DNA-damaging agents in vitro vivo, compared with wild-type cells. was associated a mutation p53 protein (His193Arg). This abated its transcriptional activity via destabilization tetrameric p53-DNA...
Abstract Lung cancer is the leading cause of mortality worldwide. In recent years, incidence lung subtype adenocarcinoma (LUAD) has steadily increased. Mitochondria, as a pivotal site cell bioenergetics, metabolism, signaling, and death, are often dysregulated in cells. Mitochondria maintenance integrity depend on mitochondrial quality control proteins (MQCPs). During progression, levels MQCPs could change promote adaptation to microenvironment stresses. Here, univariate multivariate...
A hypoxic environment of rapidly growing tumor cells makes them resistant to antitumor drugs. Mimicking hypoxia with iron chelator deferoxamine, suppressed cell death induced by widely used anticancer drugs doxorubicin or cisplatin. Deferoxamine decreased the number dead (detached) cells, size SubG1 population, release cytochrome c, and processing caspase-3 in HCT116 colon carcinoma treated cisplatin doxorubicin. Deferoxamine-mediated suppression apoptosis correlated level pro-apoptotic...